SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eyn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 6 ASN A 163
HIS A 184
TYR A 161
GLY A 194
 None
 1.39A 1mxdA-2eynA:
undetectable		 1mxdA-2eynA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 6 ARG A 187
ILE A 218
PHE A 249
GLU A 257
 None
 1.19A 1nsiA-2eynA:
undetectable
1nsiB-2eynA:
undetectable		 1nsiA-2eynA:
19.49
1nsiB-2eynA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 6 PHE A 249
GLU A 257
ARG A 187
ILE A 218
 None
 1.21A 1nsiA-2eynA:
undetectable
1nsiB-2eynA:
undetectable		 1nsiA-2eynA:
19.49
1nsiB-2eynA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 6 ARG A 187
ILE A 218
PHE A 249
GLU A 257
 None
 1.24A 1nsiC-2eynA:
undetectable
1nsiD-2eynA:
undetectable		 1nsiC-2eynA:
19.49
1nsiD-2eynA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 6 PHE A 249
GLU A 257
ARG A 187
ILE A 218
 None
 1.26A 1nsiC-2eynA:
undetectable
1nsiD-2eynA:
undetectable		 1nsiC-2eynA:
19.49
1nsiD-2eynA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 7 ARG A 187
ILE A 218
PHE A 249
GLU A 257
 None
 1.24A 2nsiA-2eynA:
undetectable
2nsiB-2eynA:
undetectable		 2nsiA-2eynA:
19.49
2nsiB-2eynA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 7 PHE A 249
GLU A 257
ARG A 187
ILE A 218
 None
 1.23A 2nsiA-2eynA:
undetectable
2nsiB-2eynA:
undetectable		 2nsiA-2eynA:
19.49
2nsiB-2eynA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 7 ARG A 187
ILE A 218
PHE A 249
GLU A 257
 None
 1.26A 2nsiC-2eynA:
undetectable
2nsiD-2eynA:
undetectable		 2nsiC-2eynA:
19.49
2nsiD-2eynA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 7 PHE A 249
GLU A 257
ARG A 187
ILE A 218
 None
 1.25A 2nsiC-2eynA:
undetectable
2nsiD-2eynA:
undetectable		 2nsiC-2eynA:
19.49
2nsiD-2eynA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		3 / 3 LEU A 202
PRO A 201
LEU A 205
 None
 0.54A 2po5B-2eynA:
undetectable		 2po5B-2eynA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 7 ARG A 187
ILE A 218
PHE A 249
GLU A 257
 None
 1.17A 3e7gA-2eynA:
undetectable
3e7gB-2eynA:
undetectable		 3e7gA-2eynA:
19.53
3e7gB-2eynA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 7 PHE A 249
GLU A 257
ARG A 187
ILE A 218
 None
 1.16A 3e7gA-2eynA:
undetectable
3e7gB-2eynA:
undetectable		 3e7gA-2eynA:
19.53
3e7gB-2eynA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 7 ARG A 187
ILE A 218
PHE A 249
GLU A 257
 None
 1.18A 3e7gC-2eynA:
undetectable
3e7gD-2eynA:
undetectable		 3e7gC-2eynA:
19.53
3e7gD-2eynA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 8 PHE A 249
GLU A 257
ARG A 187
ILE A 218
 None
 1.15A 3e7gC-2eynA:
undetectable
3e7gD-2eynA:
undetectable		 3e7gC-2eynA:
19.53
3e7gD-2eynA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 6 VAL A 242
SER A 172
LEU A 196
LEU A 182
 None
 0.89A 3kk6A-2eynA:
undetectable		 3kk6A-2eynA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 8 PHE A 249
GLU A 257
ARG A 187
ILE A 218
 None
 1.29A 4cx7A-2eynA:
undetectable
4cx7B-2eynA:
undetectable		 4cx7A-2eynA:
19.49
4cx7B-2eynA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 7 PHE A 249
GLU A 257
ARG A 187
ILE A 218
 None
 1.20A 4cx7C-2eynA:
undetectable
4cx7D-2eynA:
undetectable		 4cx7C-2eynA:
19.49
4cx7D-2eynA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		3 / 3 ARG A  34
LYS A  35
LYS A  31
 None
 1.01A 4k50A-2eynA:
undetectable		 4k50A-2eynA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		3 / 3 ARG A  34
LYS A  35
LYS A  31
 None
 0.94A 4k50E-2eynA:
undetectable		 4k50E-2eynA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		3 / 3 ARG A  34
LYS A  35
LYS A  31
 None
 0.92A 4k50I-2eynA:
undetectable		 4k50I-2eynA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		3 / 3 ASP A 117
LYS A 110
LEU A  97
 None
 0.97A 4ptjA-2eynA:
undetectable		 4ptjA-2eynA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		5 / 12 GLY A 176
SER A 172
ALA A 181
ASN A 163
TYR A 193
 None
 1.20A 4ymgA-2eynA:
undetectable		 4ymgA-2eynA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		5 / 12 GLY A 176
SER A 172
ALA A 181
ASN A 163
TYR A 193
 None
 1.20A 4ymgB-2eynA:
undetectable		 4ymgB-2eynA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 8 PHE A  59
GLY A  62
THR A  38
PHE A 134
 None
 0.98A 5flcB-2eynA:
undetectable		 5flcB-2eynA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		4 / 8 PHE A  59
GLY A  62
THR A  38
PHE A 134
 None
 0.97A 5flcF-2eynA:
undetectable		 5flcF-2eynA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		5 / 9 ILE A 227
PRO A 233
VAL A 164
ILE A 166
TYR A 241
 None
 1.16A 5iepA-2eynA:
undetectable		 5iepA-2eynA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		5 / 10 ILE A 127
ILE A 131
LEU A 132
ILE A 115
ASN A 119
 None
 1.29A 5vkqA-2eynA:
undetectable
5vkqD-2eynA:
undetectable		 5vkqA-2eynA:
8.78
5vkqD-2eynA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		5 / 10 ILE A 115
ASN A 119
ILE A 127
ILE A 131
LEU A 132
 None
 1.30A 5vkqA-2eynA:
undetectable
5vkqB-2eynA:
undetectable		 5vkqA-2eynA:
8.78
5vkqB-2eynA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		5 / 10 ILE A 115
ASN A 119
ILE A 127
ILE A 131
LEU A 132
 None
 1.29A 5vkqC-2eynA:
undetectable
5vkqD-2eynA:
undetectable		 5vkqC-2eynA:
8.78
5vkqD-2eynA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 2eyn ALPHA-ACTININ 1
(Homo
sapiens) 		5 / 12 LYS A 103
VAL A 105
PHE A  99
ILE A 100
ILE A 130
 None
 1.01A 6gsdA-2eynA:
undetectable		 6gsdA-2eynA:
16.67