SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 5 THR A 143
LEU A 145
GLY A 149
TYR A 162
 None
 1.30A 1gtiF-2eyqA:
undetectable		 1gtiF-2eyqA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 10 ILE A1087
LEU A1073
GLY A1074
PHE A1089
MET A1139
 None
 1.42A 1jujA-2eyqA:
undetectable		 1jujA-2eyqA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 10 ILE A1087
LEU A1073
GLY A1074
PHE A1089
MET A1139
 None
 1.42A 1jujB-2eyqA:
undetectable		 1jujB-2eyqA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 10 ILE A1087
LEU A1073
GLY A1074
PHE A1089
MET A1139
 None
 1.42A 1jujC-2eyqA:
undetectable		 1jujC-2eyqA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 10 ILE A1087
LEU A1073
GLY A1074
PHE A1089
MET A1139
 None
 1.42A 1jujD-2eyqA:
undetectable		 1jujD-2eyqA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 ARG A1029
ASP A1015
GLY A1051
ILE A1047
ILE A1017
 None
 0.89A 1muiB-2eyqA:
undetectable		 1muiB-2eyqA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 8 LEU A 850
GLU A 849
THR A 868
ILE A 875
 None
 0.87A 1qvtA-2eyqA:
undetectable		 1qvtA-2eyqA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 5 LEU A 939
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
EPE  A1152 (-2.8A)
 0.94A 1tt6B-2eyqA:
undetectable		 1tt6B-2eyqA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 LEU A 939
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
EPE  A1152 (-2.8A)
 1.04A 1tz8C-2eyqA:
undetectable
1tz8D-2eyqA:
undetectable		 1tz8C-2eyqA:
8.05
1tz8D-2eyqA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.64A 1usqB-2eyqA:
undetectable		 1usqB-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.65A 1usqC-2eyqA:
undetectable		 1usqC-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.66A 1usqD-2eyqA:
undetectable		 1usqD-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.71A 1usqE-2eyqA:
undetectable		 1usqE-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.67A 1usqF-2eyqA:
undetectable		 1usqF-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 PHE A 972
GLY A 534
GLY A 535
ILE A 759
ALA A 955
 None
 1.02A 1v2xA-2eyqA:
undetectable		 1v2xA-2eyqA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 PHE A 264
PHE A 122
LEU A  92
PHE A 265
 None
 1.03A 1wrlE-2eyqA:
undetectable		 1wrlE-2eyqA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 11 LEU A 474
LEU A1024
VAL A 484
GLY A 491
TYR A 493
 None
 1.35A 1y4lB-2eyqA:
undetectable		 1y4lB-2eyqA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 LEU A 211
LEU A 128
LEU A 136
LEU A 169
 None
 1.03A 2ab2A-2eyqA:
undetectable		 2ab2A-2eyqA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 9 GLU A  58
LEU A 441
LEU A 415
ALA A  32
ALA A  25
 None
 1.50A 2bxcB-2eyqA:
undetectable		 2bxcB-2eyqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 LYS A 340
LEU A 339
GLN A 338
LEU A  30
 None
 1.06A 2einC-2eyqA:
undetectable
2einJ-2eyqA:
undetectable		 2einC-2eyqA:
10.83
2einJ-2eyqA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 8 TYR A   7
GLY A 354
GLU A  21
GLY A  20
ALA A 351
 None
 1.46A 2ej3C-2eyqA:
undetectable		 2ej3C-2eyqA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.70A 2jkjA-2eyqA:
undetectable		 2jkjA-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.70A 2jkjB-2eyqA:
undetectable		 2jkjB-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.69A 2jkjC-2eyqA:
undetectable		 2jkjC-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 5 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.70A 2jkjD-2eyqA:
undetectable		 2jkjD-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.70A 2jkjE-2eyqA:
undetectable		 2jkjE-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 5 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.70A 2jkjF-2eyqA:
undetectable		 2jkjF-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.64A 2jklA-2eyqA:
undetectable		 2jklA-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.60A 2jklB-2eyqA:
undetectable		 2jklB-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.62A 2jklC-2eyqA:
undetectable		 2jklC-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.64A 2jklD-2eyqA:
undetectable		 2jklD-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.64A 2jklE-2eyqA:
undetectable		 2jklE-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.64A 2jklF-2eyqA:
undetectable		 2jklF-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 ALA A  32
GLU A  33
ARG A 439
MET A 426
 None
 1.27A 2ouzA-2eyqA:
1.7		 2ouzA-2eyqA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 3 LEU A 212
PRO A 213
LEU A  92
 None
 0.58A 2po5B-2eyqA:
3.5		 2po5B-2eyqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 3 LEU A 212
PRO A 213
LEU A  92
 None
 0.53A 2po7B-2eyqA:
2.3		 2po7B-2eyqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 5 LEU A 339
LEU A  30
ILE A  34
ARG A  37
 None
 0.85A 2qd4A-2eyqA:
3.3		 2qd4A-2eyqA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 3 LEU A 212
PRO A 213
LEU A  92
 None
 0.49A 2qd5B-2eyqA:
3.5		 2qd5B-2eyqA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 3 ARG A1049
GLU A1040
SER A 199
 None
 0.91A 2xkkA-2eyqA:
undetectable
2xkkC-2eyqA:
4.0		 2xkkA-2eyqA:
22.26
2xkkC-2eyqA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 ARG A1067
ILE A 529
LEU A 511
GLU A 487
 None
 0.86A 2ya7A-2eyqA:
undetectable		 2ya7A-2eyqA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 ARG A1067
ILE A 529
LEU A 511
GLU A 487
 None
 0.86A 2ya7B-2eyqA:
undetectable		 2ya7B-2eyqA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 ARG A1067
ILE A 529
LEU A 511
GLU A 487
 None
 0.86A 2ya7D-2eyqA:
2.0		 2ya7D-2eyqA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 THR A 882
ILE A 884
ILE A 885
LEU A 914
ALA A 785
 None
 1.14A 2yvlB-2eyqA:
4.9		 2yvlB-2eyqA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 THR A 882
ILE A 884
ILE A 885
LEU A 914
ALA A 785
 None
 1.16A 2yvlC-2eyqA:
3.0		 2yvlC-2eyqA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 GLY A 256
ILE A 257
ILE A 244
ASP A  79
 None
 0.95A 3a7eA-2eyqA:
2.1		 3a7eA-2eyqA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 10 ARG A 953
ILE A 952
GLY A 956
ILE A 759
MET A 976
 None
 1.29A 3adsA-2eyqA:
undetectable		 3adsA-2eyqA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 LEU A 939
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
EPE  A1152 (-2.8A)
 1.00A 3d2tA-2eyqA:
undetectable		 3d2tA-2eyqA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 VAL A 637
LEU A 773
MET A 616
ILE A 609
 None
 0.98A 3gp0A-2eyqA:
undetectable		 3gp0A-2eyqA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 3 MET A 767
CYH A 627
PRO A 760
 None
 1.12A 3h52C-2eyqA:
undetectable		 3h52C-2eyqA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 4 LEU A 358
PRO A 359
LEU A 361
ARG A 423
 None
 1.26A 3hcoA-2eyqA:
3.3		 3hcoA-2eyqA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 ILE A 952
GLY A 535
ALA A 540
PHE A 972
ALA A 946
 None
 0.79A 3jb1A-2eyqA:
undetectable		 3jb1A-2eyqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 ILE A 952
GLY A 535
ALA A 540
PHE A 972
ALA A 946
 None
 0.93A 3jb2A-2eyqA:
1.9		 3jb2A-2eyqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 ILE A 952
GLY A 535
ALA A 540
PHE A 972
ALA A 946
 None
 0.85A 3jb3A-2eyqA:
undetectable		 3jb3A-2eyqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 ARG A1049
ASP A1019
PHE A1026
ARG A1029
 None
 1.00A 3kivA-2eyqA:
undetectable		 3kivA-2eyqA:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 ILE A  45
VAL A  43
LEU A 106
LEU A  70
 None
 0.86A 3kp6A-2eyqA:
undetectable
3kp6B-2eyqA:
undetectable		 3kp6A-2eyqA:
9.37
3kp6B-2eyqA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 7 GLU A  15
VAL A 337
GLN A  16
ALA A 349
ARG A  17
 None
 1.33A 3kp6B-2eyqA:
undetectable		 3kp6B-2eyqA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 9 ARG A 456
ILE A 877
LEU A 850
PHE A 632
GLY A 633
 EPE  A1152 ( 4.8A)
None
None
None
None
 1.30A 3nxuB-2eyqA:
undetectable		 3nxuB-2eyqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 5 PRO A 213
ILE A 257
TRP A  73
PHE A 122
 None
 1.17A 3topB-2eyqA:
0.1		 3topB-2eyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 LEU A1119
ILE A1087
LEU A1073
GLY A1074
PHE A1089
 None
 1.02A 3uwlB-2eyqA:
undetectable		 3uwlB-2eyqA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 4 PRO A 467
LEU A 945
HIS A 897
LEU A 896
 None
None
EPE  A1151 (-4.2A)
None
 1.22A 3vw7A-2eyqA:
0.4		 3vw7A-2eyqA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 PHE A 734
VAL A 728
ILE A 751
GLU A 957
HIS A 738
 None
 1.28A 4a97B-2eyqA:
undetectable
4a97C-2eyqA:
undetectable		 4a97B-2eyqA:
13.36
4a97C-2eyqA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 8 ILE A1075
ILE A1087
VAL A1135
GLY A1080
 None
 0.80A 4ac9C-2eyqA:
undetectable		 4ac9C-2eyqA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 8 ILE A1075
ILE A1087
VAL A1135
GLY A1080
 None
 0.75A 4acaC-2eyqA:
undetectable		 4acaC-2eyqA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 8 ILE A1075
ILE A1087
VAL A1135
GLY A1080
 None
 0.72A 4acbC-2eyqA:
undetectable		 4acbC-2eyqA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 3 LEU A 288
GLU A 289
SER A 291
 None
 0.74A 4ccqA-2eyqA:
undetectable		 4ccqA-2eyqA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 LEU A 939
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
EPE  A1152 (-2.8A)
 1.05A 4d7bB-2eyqA:
undetectable		 4d7bB-2eyqA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 ALA A 373
ASP A 372
VAL A 363
ILE A 407
 None
 0.90A 4eyrA-2eyqA:
undetectable		 4eyrA-2eyqA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 LEU A 939
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
EPE  A1152 (-2.8A)
 1.00A 4i89A-2eyqA:
undetectable		 4i89A-2eyqA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 5 LEU A 339
LEU A  30
ILE A  34
ARG A  37
 None
 0.84A 4klrA-2eyqA:
3.6		 4klrA-2eyqA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 3 LEU A  30
ILE A  34
ARG A  37
 None
 0.34A 4mk4B-2eyqA:
2.0		 4mk4B-2eyqA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 ASN A1081
VAL A1086
GLU A1079
ARG A1118
 None
 1.22A 4mv7A-2eyqA:
2.3		 4mv7A-2eyqA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 8 LEU A 754
MET A 616
LEU A 725
ILE A 680
 None
 0.98A 4ok1A-2eyqA:
undetectable		 4ok1A-2eyqA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 6 LEU A 939
THR A 882
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
None
EPE  A1152 (-2.8A)
 1.36A 4pwjA-2eyqA:
undetectable		 4pwjA-2eyqA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 LEU A 939
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
EPE  A1152 (-2.8A)
 1.00A 4pwjB-2eyqA:
undetectable		 4pwjB-2eyqA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 3 PHE A1121
THR A1002
LEU A1006
 None
 0.72A 4qztA-2eyqA:
undetectable		 4qztA-2eyqA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 LEU A1060
SER A1010
ILE A1063
VAL A1004
 None
 1.16A 4tvtA-2eyqA:
undetectable		 4tvtA-2eyqA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 3 LEU A 803
ARG A 804
ARG A 302
 None
 0.81A 4yiaB-2eyqA:
undetectable		 4yiaB-2eyqA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 4 ARG A 395
GLY A 393
GLU A 392
 SO4  A1150 (-3.3A)
None
None
 0.58A 4z2dB-2eyqA:
undetectable
4z2dC-2eyqA:
3.4		 4z2dB-2eyqA:
19.44
4z2dC-2eyqA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 ILE A  88
HIS A 215
LEU A  92
GLY A 160
 None
 0.95A 4z69A-2eyqA:
undetectable		 4z69A-2eyqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 8 ALA A 540
PRO A 482
VAL A 490
ALA A 536
GLY A 534
 None
 1.14A 4zjzB-2eyqA:
2.1		 4zjzB-2eyqA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 LEU A 939
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
EPE  A1152 (-2.8A)
 0.96A 5bojA-2eyqA:
undetectable		 5bojA-2eyqA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 LEU A 939
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
EPE  A1152 (-2.8A)
 0.99A 5bojB-2eyqA:
undetectable		 5bojB-2eyqA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 3 ASP A  72
GLU A 216
SER A 291
 None
 0.75A 5bw4B-2eyqA:
undetectable		 5bw4B-2eyqA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 ILE A 471
LEU A 974
VAL A 483
VAL A 484
LEU A 945
 None
 1.30A 5bykA-2eyqA:
undetectable		 5bykA-2eyqA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 5 ASP A 949
HIS A 948
GLY A 942
ALA A 941
 None
None
EPE  A1151 (-2.7A)
EPE  A1151 (-4.1A)
 0.93A 5hwaA-2eyqA:
undetectable		 5hwaA-2eyqA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 LEU A 939
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
EPE  A1152 (-2.8A)
 0.97A 5l4iA-2eyqA:
undetectable		 5l4iA-2eyqA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 LEU A 939
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
EPE  A1152 (-2.8A)
 0.99A 5l4iB-2eyqA:
undetectable		 5l4iB-2eyqA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 ILE A 775
THR A 947
LEU A 958
LEU A 959
LEU A 763
 None
 0.91A 5nfjA-2eyqA:
undetectable		 5nfjA-2eyqA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 ILE A 775
THR A 947
LEU A 958
LEU A 959
LEU A 763
 None
 0.87A 5nfjB-2eyqA:
undetectable		 5nfjB-2eyqA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 5 ASP A 623
ARG A 746
ARG A 575
LEU A 763
 None
 1.41A 5tuiB-2eyqA:
0.0		 5tuiB-2eyqA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 4 PHE A 669
LEU A 613
LEU A 725
VAL A 637
 None
 1.36A 5xxiA-2eyqA:
undetectable		 5xxiA-2eyqA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 10 GLY A 166
ARG A 165
ALA A 163
LEU A 169
PHE A 122
 None
 1.38A 5zjiA-2eyqA:
undetectable
5zjiJ-2eyqA:
undetectable		 5zjiA-2eyqA:
5.83
5zjiJ-2eyqA:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 GLY A 433
GLY A  24
ALA A  26
ILE A 444
LEU A 358
 None
 1.16A 6b3bA-2eyqA:
2.2		 6b3bA-2eyqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 9 VAL A 197
ARG A 783
ALA A 785
VAL A 786
ASP A 938
 None
None
None
None
EPE  A1151 (-3.5A)
 1.24A 6c2mA-2eyqA:
undetectable		 6c2mA-2eyqA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 ALA A 880
GLY A 901
GLY A 904
ARG A 782
PHE A 943
 None
None
None
EPE  A1152 (-2.5A)
None
 1.20A 6clxA-2eyqA:
2.9		 6clxA-2eyqA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 GLY A 633
GLY A 631
PHE A 599
GLU A 600
ILE A 609
 None
 0.99A 6ectA-2eyqA:
2.6		 6ectA-2eyqA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 LEU A1060
ALA A1064
SER A 524
ASN A 473
 None
 0.99A 6f88A-2eyqA:
0.6		 6f88A-2eyqA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 5 GLN A 261
GLU A 216
ASP A  72
TYR A 259
 None
 1.41A 6iftA-2eyqA:
2.0		 6iftA-2eyqA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 LEU A1119
ILE A1087
LEU A1073
GLY A1074
PHE A1089
 None
 0.96A 6qxsB-2eyqA:
undetectable		 6qxsB-2eyqA:
14.16