SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eyu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2eyu TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 12 MET A 218
LEU A 140
THR A 152
ILE A 153
SER A 147
 None
 1.43A 1xlxA-2eyuA:
undetectable		 1xlxA-2eyuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2eyu TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 12 MET A 218
THR A 152
ILE A 153
SER A 147
GLN A 279
 None
 1.47A 1xlxA-2eyuA:
undetectable		 1xlxA-2eyuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2eyu TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 12 MET A 218
LEU A 140
THR A 152
ILE A 153
SER A 147
 None
 1.46A 1xomB-2eyuA:
undetectable		 1xomB-2eyuA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2eyu TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 12 MET A 218
THR A 152
ILE A 153
SER A 147
GLN A 279
 None
 1.47A 1xomB-2eyuA:
undetectable		 1xomB-2eyuA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2eyu TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		4 / 5 LEU A 305
GLY A 321
ALA A 301
ILE A 302
 None
 0.74A 2aohB-2eyuA:
undetectable		 2aohB-2eyuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2eyu TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 12 MET A 218
LEU A 140
THR A 152
ILE A 153
SER A 147
 None
 1.46A 3g4lD-2eyuA:
undetectable		 3g4lD-2eyuA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2eyu TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 12 ILE A 250
ALA A 246
MET A 327
ILE A 306
THR A 245
 None
 1.18A 3ql3A-2eyuA:
undetectable		 3ql3A-2eyuA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2eyu TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 12 ILE A 213
ALA A 230
ALA A 227
LEU A 138
ILE A 157
 None
 1.24A 3uvvB-2eyuA:
undetectable		 3uvvB-2eyuA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 2eyu TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 12 ALA A 246
ILE A 277
THR A 333
LEU A 291
THR A 249
 None
 1.27A 4cd2A-2eyuA:
undetectable		 4cd2A-2eyuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2eyu TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 12 ILE A 276
LEU A 295
GLY A 294
LYS A 127
MET A 327
 None
 1.30A 4eb4B-2eyuA:
undetectable		 4eb4B-2eyuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2eyu TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		4 / 9 ILE A 253
THR A 142
ASP A 248
ILE A 276
 None
 1.04A 5lg3I-2eyuA:
undetectable		 5lg3I-2eyuA:
22.09