SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ezv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2ezv TYPE II RESTRICTION
ENZYME SFII
(Streptomyces
fimbriatus) 		5 / 12 PHE A 204
MET A 119
ARG A 233
LEU A 186
ILE A 219
 None
 1.30A 1kqwA-2ezvA:
undetectable		 1kqwA-2ezvA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2ezv TYPE II RESTRICTION
ENZYME SFII
(Streptomyces
fimbriatus) 		4 / 7 GLY A 207
SER A 210
ARG A 220
GLU A 215
 None
 1.04A 2c8aD-2ezvA:
undetectable		 2c8aD-2ezvA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2ezv TYPE II RESTRICTION
ENZYME SFII
(Streptomyces
fimbriatus) 		5 / 12 PHE A 160
PHE A 204
ALA A 101
ALA A 121
ALA A 136
 None
None
CA  A 270 (-4.6A)
None
None
 1.01A 2x2nB-2ezvA:
undetectable		 2x2nB-2ezvA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2ezv TYPE II RESTRICTION
ENZYME SFII
(Streptomyces
fimbriatus) 		5 / 12 ARG A  84
ALA A  61
THR A  58
VAL A  99
LEU A  98
 None
 1.26A 3s79A-2ezvA:
undetectable		 3s79A-2ezvA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 2ezv TYPE II RESTRICTION
ENZYME SFII
(Streptomyces
fimbriatus) 		5 / 11 LEU A  62
VAL A  99
GLU A  66
LEU A  21
THR A 157
 None
 1.29A 3tbgA-2ezvA:
undetectable		 3tbgA-2ezvA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 2ezv TYPE II RESTRICTION
ENZYME SFII
(Streptomyces
fimbriatus) 		5 / 10 LEU A  62
VAL A  99
GLU A  66
LEU A  21
THR A 157
 None
 1.35A 3tbgC-2ezvA:
undetectable		 3tbgC-2ezvA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2ezv TYPE II RESTRICTION
ENZYME SFII
(Streptomyces
fimbriatus) 		4 / 8 SER A 185
ARG A  84
ILE A 159
GLU A  17
 None
 1.28A 4cx7A-2ezvA:
undetectable
4cx7B-2ezvA:
undetectable		 4cx7A-2ezvA:
19.82
4cx7B-2ezvA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2ezv TYPE II RESTRICTION
ENZYME SFII
(Streptomyces
fimbriatus) 		3 / 3 SER A 243
SER A 240
PHE A 266
 None
 0.74A 5mugA-2ezvA:
undetectable		 5mugA-2ezvA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 2ezv TYPE II RESTRICTION
ENZYME SFII
(Streptomyces
fimbriatus) 		4 / 6 TYR A   5
PRO A 187
LEU A 186
LEU A 191
 None
 1.09A 5tl8A-2ezvA:
undetectable		 5tl8A-2ezvA:
20.13