SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f07'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2f07 YVDT
(Bacillus
subtilis) 		4 / 7 GLU A 160
GLU A 164
TYR A 106
TYR A 122
 BTB  A 289 (-3.3A)
BTB  A 289 (-4.0A)
BTB  A 289 (-4.8A)
BTB  A 289 (-3.8A)
 1.19A 4twdF-2f07A:
undetectable
4twdJ-2f07A:
undetectable		 4twdF-2f07A:
19.74
4twdJ-2f07A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2f07 YVDT
(Bacillus
subtilis) 		4 / 7 GLU A 164
GLU A 160
TYR A 122
TYR A 106
 BTB  A 289 (-4.0A)
BTB  A 289 (-3.3A)
BTB  A 289 (-3.8A)
BTB  A 289 (-4.8A)
 1.07A 4twdF-2f07A:
undetectable
4twdJ-2f07A:
undetectable		 4twdF-2f07A:
19.74
4twdJ-2f07A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2f07 YVDT
(Bacillus
subtilis) 		4 / 6 TYR A 106
GLU A 164
GLU A 160
TYR A 122
 BTB  A 289 (-4.8A)
BTB  A 289 (-4.0A)
BTB  A 289 (-3.3A)
BTB  A 289 (-3.8A)
 1.10A 4twdG-2f07A:
undetectable
4twdH-2f07A:
1.9		 4twdG-2f07A:
19.74
4twdH-2f07A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2f07 YVDT
(Bacillus
subtilis) 		4 / 6 TYR A 122
GLU A 160
GLU A 164
TYR A 106
 BTB  A 289 (-3.8A)
BTB  A 289 (-3.3A)
BTB  A 289 (-4.0A)
BTB  A 289 (-4.8A)
 1.24A 4twdG-2f07A:
undetectable
4twdH-2f07A:
1.9		 4twdG-2f07A:
19.74
4twdH-2f07A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2f07 YVDT
(Bacillus
subtilis) 		4 / 5 TYR A 106
GLU A 164
GLU A 160
TYR A 122
 BTB  A 289 (-4.8A)
BTB  A 289 (-4.0A)
BTB  A 289 (-3.3A)
BTB  A 289 (-3.8A)
 1.06A 4twdH-2f07A:
1.9
4twdI-2f07A:
undetectable		 4twdH-2f07A:
19.74
4twdI-2f07A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2f07 YVDT
(Bacillus
subtilis) 		4 / 5 TYR A 122
GLU A 160
GLU A 164
TYR A 106
 BTB  A 289 (-3.8A)
BTB  A 289 (-3.3A)
BTB  A 289 (-4.0A)
BTB  A 289 (-4.8A)
 1.19A 4twdH-2f07A:
1.9
4twdI-2f07A:
undetectable		 4twdH-2f07A:
19.74
4twdI-2f07A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2f07 YVDT
(Bacillus
subtilis) 		5 / 8 ALA A  57
ALA A  59
ILE A  58
ALA A 110
LEU A 104
 None
 1.14A 4v1fA-2f07A:
undetectable
4v1fB-2f07A:
undetectable		 4v1fA-2f07A:
21.39
4v1fB-2f07A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 2f07 YVDT
(Bacillus
subtilis) 		4 / 6 LEU A 104
ILE A  20
ALA A  16
ALA A  57
 None
 0.79A 4zf8A-2f07A:
undetectable		 4zf8A-2f07A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2f07 YVDT
(Bacillus
subtilis) 		4 / 8 ILE A  17
ILE A  58
LEU A  54
LEU A 104
 None
 0.79A 4zvcA-2f07A:
2.8
4zvcB-2f07A:
3.0		 4zvcA-2f07A:
21.08
4zvcB-2f07A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2f07 YVDT
(Bacillus
subtilis) 		4 / 8 ILE A  58
LEU A  54
LEU A 104
ILE A  17
 None
 0.79A 4zvcA-2f07A:
2.8
4zvcB-2f07A:
3.0		 4zvcA-2f07A:
21.08
4zvcB-2f07A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 2f07 YVDT
(Bacillus
subtilis) 		5 / 12 PHE A  92
ILE A 183
LEU A 191
LEU A  87
ALA A 152
 None
 1.30A 5fctB-2f07A:
undetectable		 5fctB-2f07A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 2f07 YVDT
(Bacillus
subtilis) 		4 / 7 TYR A 125
TYR A 122
ASP A  68
HIS A  65
 None
BTB  A 289 (-3.8A)
None
None
 1.40A 5ov9B-2f07A:
undetectable		 5ov9B-2f07A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 2f07 YVDT
(Bacillus
subtilis) 		5 / 12 LEU A  13
PHE A  48
ILE A  33
ALA A  28
GLY A 108
 None
 1.11A 5veuA-2f07A:
undetectable		 5veuA-2f07A:
18.40