SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f1f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 9 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.19A 1c9sS-2f1fA:
undetectable
1c9sT-2f1fA:
undetectable		 1c9sS-2f1fA:
20.48
1c9sT-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		4 / 5 THR A  47
THR A  34
GLU A  85
THR A 127
 None
 1.03A 1d4fB-2f1fA:
undetectable		 1d4fB-2f1fA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 9 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.20A 1gtfR-2f1fA:
undetectable
1gtfS-2f1fA:
undetectable		 1gtfR-2f1fA:
20.48
1gtfS-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 10 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.20A 1gtfT-2f1fA:
undetectable
1gtfU-2f1fA:
undetectable		 1gtfT-2f1fA:
20.48
1gtfU-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 9 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.19A 1gtnL-2f1fA:
undetectable
1gtnM-2f1fA:
undetectable		 1gtnL-2f1fA:
20.48
1gtnM-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 9 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.17A 1gtnR-2f1fA:
undetectable
1gtnS-2f1fA:
undetectable		 1gtnR-2f1fA:
20.48
1gtnS-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 11 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.19A 1utdM-2f1fA:
undetectable
1utdN-2f1fA:
undetectable		 1utdM-2f1fA:
20.48
1utdN-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 10 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.21A 1utdQ-2f1fA:
undetectable
1utdR-2f1fA:
undetectable		 1utdQ-2f1fA:
20.48
1utdR-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 11 VAL A  19
ILE A  20
ASN A  29
ILE A  30
SER A  32
 None
 1.27A 3kpcA-2f1fA:
undetectable		 3kpcA-2f1fA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		4 / 8 VAL A 152
ARG A  45
VAL A   7
ILE A  48
 None
 1.04A 3remA-2f1fA:
undetectable		 3remA-2f1fA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		4 / 8 VAL A 152
ARG A  45
VAL A   7
ILE A  48
 None
 1.01A 3remB-2f1fA:
undetectable		 3remB-2f1fA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		4 / 5 ARG A   2
ILE A   4
HIS A  81
GLY A  77
 None
 1.41A 4e7cC-2f1fA:
undetectable		 4e7cC-2f1fA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 9 SER A 150
GLY A 154
THR A  34
THR A  47
ILE A   4
 None
 1.22A 5eeyB-2f1fA:
undetectable
5eeyC-2f1fA:
undetectable		 5eeyB-2f1fA:
20.48
5eeyC-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 10 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.19A 5eeyS-2f1fA:
undetectable
5eeyT-2f1fA:
undetectable		 5eeyS-2f1fA:
20.48
5eeyT-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 9 SER A 150
GLY A 154
THR A  34
THR A  47
ILE A   4
 None
 1.22A 5eezB-2f1fA:
undetectable
5eezC-2f1fA:
undetectable		 5eezB-2f1fA:
20.48
5eezC-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 10 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.19A 5eezS-2f1fA:
undetectable
5eezT-2f1fA:
undetectable		 5eezS-2f1fA:
20.48
5eezT-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 9 SER A 150
GLY A 154
THR A  34
THR A  47
ILE A   4
 None
 1.22A 5ef0B-2f1fA:
undetectable
5ef0C-2f1fA:
undetectable		 5ef0B-2f1fA:
20.48
5ef0C-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 10 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.19A 5ef0S-2f1fA:
undetectable
5ef0T-2f1fA:
undetectable		 5ef0S-2f1fA:
20.48
5ef0T-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 9 SER A 150
GLY A 154
THR A  34
THR A  47
ILE A   4
 None
 1.22A 5ef1B-2f1fA:
undetectable
5ef1C-2f1fA:
undetectable		 5ef1B-2f1fA:
20.48
5ef1C-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 10 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.19A 5ef1S-2f1fA:
undetectable
5ef1T-2f1fA:
undetectable		 5ef1S-2f1fA:
20.48
5ef1T-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 9 SER A 150
GLY A 154
THR A  34
THR A  47
ILE A   4
 None
 1.22A 5ef2B-2f1fA:
undetectable
5ef2C-2f1fA:
undetectable		 5ef2B-2f1fA:
20.48
5ef2C-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 10 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.19A 5ef2S-2f1fA:
undetectable
5ef2T-2f1fA:
undetectable		 5ef2S-2f1fA:
20.48
5ef2T-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 9 SER A 150
GLY A 154
THR A  34
THR A  47
ILE A   4
 None
 1.22A 5ef3B-2f1fA:
undetectable
5ef3C-2f1fA:
undetectable		 5ef3B-2f1fA:
20.48
5ef3C-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT
(Escherichia
coli) 		5 / 10 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.19A 5ef3S-2f1fA:
undetectable
5ef3T-2f1fA:
undetectable		 5ef3S-2f1fA:
20.48
5ef3T-2f1fA:
20.48