SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f1k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 GLY A  17
GLY A   4
ARG A  20
GLY A  28
 None
 0.76A 1jhqA-2f1kA:
undetectable		 1jhqA-2f1kA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 GLY A  17
GLY A   4
ARG A  20
GLY A  28
 None
 0.75A 1jhvA-2f1kA:
undetectable		 1jhvA-2f1kA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A 155
ALA A 115
VAL A 154
LEU A  19
HIS A 112
 None
OMT  A 114 (-3.1A)
OCS  A 150 ( 3.9A)
None
OMT  A 114 ( 3.9A)
 1.42A 1kt7A-2f1kA:
undetectable		 1kt7A-2f1kA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ALA A 101
ILE A  70
GLY A 110
ILE A 109
 None
 0.68A 2o4nB-2f1kA:
undetectable		 2o4nB-2f1kA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 LEU A  19
ILE A  60
ILE A  78
LEU A  52
 None
 0.93A 2xkwB-2f1kA:
undetectable		 2xkwB-2f1kA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 ALA A 236
HIS A 179
VAL A 174
HIS A 170
 None
None
OMT  A 114 ( 4.7A)
None
 1.21A 3nneG-2f1kA:
undetectable		 3nneG-2f1kA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A  12
ALA A  13
GLY A  28
VAL A  29
ILE A 122
 None
 0.85A 3nu5A-2f1kA:
undetectable		 3nu5A-2f1kA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A  12
GLY A   9
ILE A 122
ARG A  20
VAL A   5
 None
NAP  A1350 (-3.0A)
None
None
None
 0.96A 3o7wA-2f1kA:
2.3		 3o7wA-2f1kA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 GLY A  12
ALA A  13
GLY A  28
VAL A  29
ILE A 122
 None
 0.93A 3oxvA-2f1kA:
undetectable		 3oxvA-2f1kA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 GLY A  12
ALA A  13
GLY A  28
VAL A  29
ILE A 122
 None
 0.92A 3oxvC-2f1kA:
undetectable		 3oxvC-2f1kA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A  12
ALA A  13
GLY A  28
VAL A  29
ILE A 122
 None
 0.90A 3oxxA-2f1kA:
undetectable		 3oxxA-2f1kA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A  45
ILE A  11
VAL A  90
CYH A  64
TYR A 135
 None
NAP  A1350 (-4.1A)
NAP  A1350 (-4.7A)
None
None
 1.46A 3p6gA-2f1kA:
undetectable		 3p6gA-2f1kA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 164
GLY A 111
HIS A 112
ALA A 101
PRO A 167
 None
None
OMT  A 114 ( 3.9A)
None
None
 1.29A 3tm4A-2f1kA:
6.7		 3tm4A-2f1kA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 164
GLY A 111
HIS A 112
ALA A 101
PRO A 167
 None
None
OMT  A 114 ( 3.9A)
None
None
 1.32A 3tm4B-2f1kA:
6.7		 3tm4B-2f1kA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A  12
GLY A   7
ILE A 122
ALA A 125
PHE A  62
 None
NAP  A1350 (-3.5A)
None
None
None
 1.18A 4kicA-2f1kA:
5.9		 4kicA-2f1kA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 LEU A 158
LEU A 155
LEU A 151
VAL A   5
 None
None
OCS  A 150 ( 4.6A)
None
 0.89A 4klaA-2f1kA:
2.1		 4klaA-2f1kA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 THR A 215
LEU A 248
GLN A 242
LEU A 241
 None
 1.19A 4nc3A-2f1kA:
undetectable		 4nc3A-2f1kA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A  19
LEU A  26
GLY A  17
SER A  14
ILE A   3
 None
 1.00A 4xj7C-2f1kA:
4.0
4xj7D-2f1kA:
2.8		 4xj7C-2f1kA:
19.94
4xj7D-2f1kA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2f1k PREPHENATE
DEHYDROGENASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 LEU A  10
GLY A  12
GLY A   7
ALA A 125
 NAP  A1350 (-4.3A)
None
NAP  A1350 (-3.5A)
None
 0.73A 5o96C-2f1kA:
undetectable		 5o96C-2f1kA:
22.40