SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f1n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		4 / 8 GLN A  43
VAL A  89
GLY A  46
GLY A  94
 None
 0.71A 1f5lA-2f1nA:
undetectable		 1f5lA-2f1nA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		4 / 8 ASP A 107
ASP A 130
ILE A 125
ILE A  39
 None
 0.70A 1sh9A-2f1nA:
undetectable		 1sh9A-2f1nA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		5 / 12 PHE A 175
THR A   9
VAL A 246
VAL A 214
LEU A 122
 None
 1.09A 2g78A-2f1nA:
undetectable		 2g78A-2f1nA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		4 / 8 GLN A  43
VAL A  89
GLY A  46
GLY A  94
 None
 0.66A 2vinA-2f1nA:
undetectable		 2vinA-2f1nA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		5 / 11 LEU A 123
LEU A 100
LEU A  98
HIS A 136
THR A   9
 None
 1.40A 2x7hA-2f1nA:
0.1
2x7hB-2f1nA:
0.1		 2x7hA-2f1nA:
24.54
2x7hB-2f1nA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		3 / 3 VAL A  96
ASN A  11
TRP A  10
 None
 0.89A 2y00B-2f1nA:
undetectable		 2y00B-2f1nA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		3 / 3 GLU A  44
ASP A 174
ASP A 242
 None
 0.76A 3jb2A-2f1nA:
undetectable		 3jb2A-2f1nA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		3 / 3 VAL A 190
SER A 194
LEU A 186
 None
 0.75A 3n8xA-2f1nA:
undetectable		 3n8xA-2f1nA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		5 / 12 ASN A 129
ASP A 130
LEU A 226
GLY A 216
SER A 218
 None
 1.33A 4djeA-2f1nA:
undetectable		 4djeA-2f1nA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		4 / 8 ILE A 125
PRO A  49
VAL A  82
TRP A  71
 None
 1.24A 4f4dB-2f1nA:
undetectable		 4f4dB-2f1nA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		5 / 9 THR A   9
ALA A 213
ALA A 215
GLY A 247
ALA A 228
 None
 1.11A 4qvnK-2f1nA:
undetectable
4qvnL-2f1nA:
undetectable		 4qvnK-2f1nA:
20.00
4qvnL-2f1nA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		5 / 9 THR A   9
ALA A 213
ALA A 215
GLY A 247
ALA A 228
 None
 1.11A 4qvnY-2f1nA:
undetectable
4qvnZ-2f1nA:
undetectable		 4qvnY-2f1nA:
20.00
4qvnZ-2f1nA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		5 / 9 THR A   9
ALA A 213
ALA A 215
GLY A 247
ALA A 228
 None
 1.11A 4qvqK-2f1nA:
undetectable
4qvqL-2f1nA:
undetectable		 4qvqK-2f1nA:
20.99
4qvqL-2f1nA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		5 / 9 THR A   9
ALA A 213
ALA A 215
GLY A 247
ALA A 228
 None
 1.11A 4qvqY-2f1nA:
undetectable
4qvqZ-2f1nA:
undetectable		 4qvqY-2f1nA:
20.99
4qvqZ-2f1nA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		4 / 6 ALA A 135
GLN A  43
LEU A 122
LEU A 100
 None
 1.18A 4xoyA-2f1nA:
undetectable		 4xoyA-2f1nA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		4 / 6 LEU A 167
LEU A   2
ILE A 125
PHE A 132
 None
 1.18A 4y4dA-2f1nA:
undetectable		 4y4dA-2f1nA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		4 / 5 ILE A 125
ILE A  59
TYR A  85
GLU A  68
 None
 0.98A 4zzcE-2f1nA:
undetectable		 4zzcE-2f1nA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		5 / 9 THR A   9
ALA A 213
ALA A 215
GLY A 247
ALA A 228
 None
 1.06A 5l5zK-2f1nA:
undetectable
5l5zL-2f1nA:
undetectable		 5l5zK-2f1nA:
22.78
5l5zL-2f1nA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B
(Escherichia
coli) 		5 / 9 THR A   9
ALA A 213
ALA A 215
GLY A 247
ALA A 228
 None
 1.06A 5l5zY-2f1nA:
undetectable
5l5zZ-2f1nA:
undetectable		 5l5zY-2f1nA:
22.78
5l5zZ-2f1nA:
22.86