SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		3 / 3 ASP A 168
LEU A 164
LEU A 169
 None
 0.76A 1ikeA-2f1sA:
undetectable		 1ikeA-2f1sA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		5 / 12 LEU A 117
CYH A 120
LEU A 122
LEU A 143
LEU A 112
 None
 1.30A 1s9pB-2f1sA:
undetectable		 1s9pB-2f1sA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		5 / 12 LEU A  99
GLU A 106
LEU A 161
LEU A 169
LEU A 157
 None
 1.09A 3erdA-2f1sA:
undetectable		 3erdA-2f1sA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		5 / 12 LEU A  99
GLU A 106
LEU A 161
LEU A 169
LEU A 157
 None
 1.05A 3hm1A-2f1sA:
undetectable		 3hm1A-2f1sA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		3 / 3 GLU A 105
LEU A  27
LEU A  72
 None
 0.72A 3ohtA-2f1sA:
undetectable		 3ohtA-2f1sA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		3 / 3 GLU A 105
LEU A  27
LEU A  72
 None
 0.69A 3ohtB-2f1sA:
undetectable		 3ohtB-2f1sA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		3 / 3 TYR A  96
HIS A  33
ARG A  97
 None
 1.05A 4htfA-2f1sA:
undetectable		 4htfA-2f1sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		4 / 8 ARG A 166
VAL A 149
VAL A 103
GLY A 104
 None
 1.01A 4mk4A-2f1sA:
undetectable		 4mk4A-2f1sA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		5 / 11 LEU A 141
VAL A 140
LEU A  27
GLY A 104
ARG A  97
 None
 1.05A 4zbqA-2f1sA:
undetectable		 4zbqA-2f1sA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		5 / 11 LEU A  99
GLU A 106
LEU A 161
LEU A 169
LEU A 157
 None
 1.10A 4zn7B-2f1sA:
undetectable		 4zn7B-2f1sA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		5 / 12 LEU A 141
LEU A  67
VAL A  66
ALA A  36
GLY A  38
 None
 1.05A 5uxdB-2f1sA:
undetectable		 5uxdB-2f1sA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		4 / 5 LEU A 130
LEU A 115
ALA A 119
LEU A 122
 None
 0.86A 5vkqA-2f1sA:
undetectable
5vkqB-2f1sA:
undetectable		 5vkqA-2f1sA:
7.62
5vkqB-2f1sA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		4 / 5 LEU A 130
LEU A 115
ALA A 119
LEU A 122
 None
 0.86A 5vkqB-2f1sA:
undetectable
5vkqC-2f1sA:
undetectable		 5vkqB-2f1sA:
7.62
5vkqC-2f1sA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		4 / 5 LEU A 130
LEU A 115
ALA A 119
LEU A 122
 None
 0.89A 5vkqC-2f1sA:
undetectable
5vkqD-2f1sA:
undetectable		 5vkqC-2f1sA:
7.62
5vkqD-2f1sA:
7.62