SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f1z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 12 GLY A 215
VAL A 484
ASP A 481
SER A 270
LEU A 279
 None
 1.40A 1kiaD-2f1zA:
undetectable		 1kiaD-2f1zA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 7 PHE A 324
THR A 319
VAL A 307
ILE A 320
 None
 0.92A 1p7rA-2f1zA:
undetectable		 1p7rA-2f1zA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 4 SER A 125
SER A 129
THR A 128
SER A 127
 None
 1.46A 3loqA-2f1zA:
0.0		 3loqA-2f1zA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA597_0
(LACTOPEROXIDASE)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 5 GLN A 297
ASP A 349
ARG A 301
GLU A 298
 None
 1.19A 3r55A-2f1zA:
0.0		 3r55A-2f1zA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 10 LEU A 216
ASP A 482
ASP A 481
THR A 222
GLN A 219
 None
 1.49A 4n9uA-2f1zA:
undetectable		 4n9uA-2f1zA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 6 GLN A 297
ASP A 349
ARG A 301
GLU A 298
 None
 1.22A 4qyqC-2f1zA:
undetectable		 4qyqC-2f1zA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		3 / 3 VAL A 263
LEU A 267
VAL A 274
 None
 0.42A 4wq4A-2f1zA:
undetectable		 4wq4A-2f1zA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		3 / 3 MET A 328
ASP A 349
PHE A 324
 None
 1.02A 4xeyA-2f1zA:
undetectable		 4xeyA-2f1zA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		3 / 3 MET A 328
ASP A 349
PHE A 324
 None
 0.97A 4xeyB-2f1zA:
undetectable		 4xeyB-2f1zA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 12 ILE A 494
LEU A 431
LEU A 404
LEU A 516
TYR A 518
 None
 1.21A 4xumA-2f1zA:
undetectable		 4xumA-2f1zA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 6 GLN A 297
ASP A 349
ARG A 301
GLU A 298
 None
 1.22A 5hpwC-2f1zA:
undetectable		 5hpwC-2f1zA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 8 HIS A 201
ASP A 483
THR A 211
ASP A 481
 None
 1.18A 5t8sB-2f1zA:
undetectable		 5t8sB-2f1zA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		3 / 3 PHE A 324
ASP A 349
LEU A 396
 None
 0.64A 5uhbC-2f1zA:
undetectable		 5uhbC-2f1zA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		3 / 3 PHE A 324
ASP A 349
LEU A 396
 None
 0.57A 5uhcC-2f1zA:
undetectable		 5uhcC-2f1zA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 8 GLY A 215
LEU A 216
ASN A 226
GLN A 230
PHE A 480
 None
 0.59A 5xu8A-2f1zA:
27.4		 5xu8A-2f1zA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 8 GLY A 215
SER A 227
GLN A 230
PHE A 480
 None
 0.64A 5xu8A-2f1zA:
27.4		 5xu8A-2f1zA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 4 PHE A 283
LEU A 238
LEU A 229
VAL A 307
 None
 1.21A 5xxiA-2f1zA:
undetectable		 5xxiA-2f1zA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 6 VAL A 263
LEU A 260
LEU A 303
LEU A 238
 None
 0.82A 6f6sA-2f1zA:
undetectable
6f6sB-2f1zA:
undetectable		 6f6sA-2f1zA:
10.29
6f6sB-2f1zA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		3 / 3 PHE A 234
ARG A 239
GLN A 230
 None
 1.16A 6g1pB-2f1zA:
undetectable		 6g1pB-2f1zA:
21.58