SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2f22 BH3987
(Bacillus
halodurans) 		3 / 3 ILE A 104
LEU A 107
VAL A 111
 None
 0.47A 1mz9B-2f22A:
undetectable		 1mz9B-2f22A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 2f22 BH3987
(Bacillus
halodurans) 		4 / 6 LEU A  36
LEU A  39
TRP A  25
ILE A  20
 None
 0.64A 2rlfA-2f22A:
undetectable
2rlfB-2f22A:
undetectable		 2rlfA-2f22A:
26.51
2rlfB-2f22A:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 2f22 BH3987
(Bacillus
halodurans) 		4 / 6 LEU A  36
LEU A  39
TRP A  25
ILE A  20
 None
 0.83A 2rlfB-2f22A:
undetectable
2rlfC-2f22A:
undetectable		 2rlfB-2f22A:
26.51
2rlfC-2f22A:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 2f22 BH3987
(Bacillus
halodurans) 		4 / 6 LEU A  36
LEU A  39
TRP A  25
ILE A  20
 None
 0.55A 2rlfC-2f22A:
undetectable
2rlfD-2f22A:
undetectable		 2rlfC-2f22A:
26.51
2rlfD-2f22A:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2f22 BH3987
(Bacillus
halodurans) 		3 / 3 LEU A   7
MET A  80
MET A 105
 None
 0.91A 2vavF-2f22A:
undetectable		 2vavF-2f22A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2f22 BH3987
(Bacillus
halodurans) 		3 / 3 HIS A  42
HIS A 114
HIS A 118
 NI  A 144 (-3.3A)
NI  A 144 (-3.2A)
NI  A 144 (-3.2A)
 0.75A 3ag4A-2f22A:
undetectable		 3ag4A-2f22A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2f22 BH3987
(Bacillus
halodurans) 		5 / 12 LEU A  33
THR A  35
ILE A  30
LEU A  16
LEU A 126
 None
 0.93A 5nfjA-2f22A:
undetectable		 5nfjA-2f22A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2f22 BH3987
(Bacillus
halodurans) 		3 / 3 HIS A  42
HIS A 114
HIS A 118
 NI  A 144 (-3.3A)
NI  A 144 (-3.2A)
NI  A 144 (-3.2A)
 0.65A 6giqa-2f22A:
2.5		 6giqa-2f22A:
12.74