SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f28'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.42A 1a4gA-2f28A:
25.2		 1a4gA-2f28A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.44A 1a4gB-2f28A:
25.1		 1a4gB-2f28A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.54A 1nncA-2f28A:
20.7		 1nncA-2f28A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 10 ARG A  21
TYR A 179
GLU A 218
ARG A 237
TYR A 334
 None
 1.06A 1v3eA-2f28A:
12.9		 1v3eA-2f28A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 10 ARG A  21
TYR A 179
GLU A 218
ARG A 237
ARG A 304
 None
 0.76A 1v3eB-2f28A:
26.3		 1v3eB-2f28A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.44A 2cmlA-2f28A:
7.8		 2cmlA-2f28A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.45A 2cmlB-2f28A:
7.8		 2cmlB-2f28A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.49A 2cmlC-2f28A:
4.5		 2cmlC-2f28A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.47A 2cmlD-2f28A:
8.0		 2cmlD-2f28A:
21.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 2f28 SIALIDASE 2
(Homo
sapiens) 		10 / 12 ARG A  21
GLU A  39
MET A  85
ASN A  86
TYR A 179
TYR A 181
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.59A 2f0zA-2f28A:
59.4		 2f0zA-2f28A:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F10_A_BCZA382_0
(SIALIDASE 2)		 2f28 SIALIDASE 2
(Homo
sapiens) 		11 / 12 ARG A  21
ILE A  22
GLU A  39
MET A  85
ASN A  86
TYR A 179
LEU A 217
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.46A 2f10A-2f28A:
59.9		 2f10A-2f28A:
99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.63A 2htqA-2f28A:
21.5		 2htqA-2f28A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2f28 SIALIDASE 2
(Homo
sapiens) 		3 / 3 ARG A 204
GLY A 203
SER A 137
 None
 0.56A 2xctB-2f28A:
undetectable		 2xctB-2f28A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 2f28 SIALIDASE 2
(Homo
sapiens) 		6 / 12 ARG A  21
ILE A  22
TYR A 179
ARG A 237
ARG A 304
TYR A 334
 None
 0.41A 2ya7A-2f28A:
42.9		 2ya7A-2f28A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 2f28 SIALIDASE 2
(Homo
sapiens) 		6 / 12 ARG A  21
ILE A  22
TYR A 179
ARG A 237
ARG A 304
TYR A 334
 None
 0.42A 2ya7B-2f28A:
42.8		 2ya7B-2f28A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 2f28 SIALIDASE 2
(Homo
sapiens) 		6 / 12 ARG A  21
ILE A  22
TYR A 179
ARG A 237
ARG A 304
TYR A 334
 None
 0.41A 2ya7C-2f28A:
40.7		 2ya7C-2f28A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 2f28 SIALIDASE 2
(Homo
sapiens) 		6 / 12 ARG A  21
ILE A  22
TYR A 179
ARG A 237
ARG A 304
TYR A 334
 None
 0.41A 2ya7D-2f28A:
43.0		 2ya7D-2f28A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.42A 3b7eA-2f28A:
4.2		 3b7eA-2f28A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.42A 3b7eB-2f28A:
21.1		 3b7eB-2f28A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.43A 3ckzA-2f28A:
11.4		 3ckzA-2f28A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 10 ILE A 191
ASP A 215
THR A 216
VAL A 244
LEU A 240
 None
 1.25A 3eqmA-2f28A:
0.0		 3eqmA-2f28A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A 304
GLU A 355
GLU A  39
ARG A 237
TYR A 334
 None
 1.49A 3k39O-2f28A:
25.1		 3k39O-2f28A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2f28 SIALIDASE 2
(Homo
sapiens) 		3 / 3 VAL A 175
SER A 173
LEU A 198
 None
 0.72A 3n8xA-2f28A:
undetectable		 3n8xA-2f28A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ILE A 191
ASP A 215
THR A 216
VAL A 244
LEU A 240
 None
 1.22A 3s79A-2f28A:
undetectable		 3s79A-2f28A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.39A 3sanA-2f28A:
7.6		 3sanA-2f28A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.39A 3sanB-2f28A:
4.3		 3sanB-2f28A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.40A 3ti5A-2f28A:
21.2		 3ti5A-2f28A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.41A 3ti5B-2f28A:
4.3		 3ti5B-2f28A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.42A 3ticA-2f28A:
10.1		 3ticA-2f28A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.44A 3ticB-2f28A:
21.4		 3ticB-2f28A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.43A 3ticC-2f28A:
10.3		 3ticC-2f28A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.42A 3ticD-2f28A:
21.3		 3ticD-2f28A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.44A 4b7nA-2f28A:
11.6		 4b7nA-2f28A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A 304
GLU A 355
GLU A  39
ARG A 237
TYR A 334
 None
 1.49A 4b7nA-2f28A:
11.6		 4b7nA-2f28A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.43A 4b7qA-2f28A:
11.6		 4b7qA-2f28A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.47A 4b7qB-2f28A:
2.4		 4b7qB-2f28A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.42A 4b7qC-2f28A:
11.8		 4b7qC-2f28A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.48A 4b7qD-2f28A:
21.2		 4b7qD-2f28A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.42A 4cpnA-2f28A:
12.5		 4cpnA-2f28A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.43A 4cpnB-2f28A:
25.2		 4cpnB-2f28A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.43A 4cpzA-2f28A:
25.1		 4cpzA-2f28A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.40A 4cpzB-2f28A:
8.0		 4cpzB-2f28A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.40A 4cpzC-2f28A:
7.2		 4cpzC-2f28A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.35A 4cpzD-2f28A:
12.5		 4cpzD-2f28A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.43A 4cpzE-2f28A:
7.2		 4cpzE-2f28A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.47A 4cpzF-2f28A:
25.2		 4cpzF-2f28A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.40A 4cpzG-2f28A:
25.2		 4cpzG-2f28A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.54A 4cpzH-2f28A:
25.0		 4cpzH-2f28A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 2f28 SIALIDASE 2
(Homo
sapiens) 		4 / 7 LEU A 294
ALA A 309
LEU A 311
SER A 322
 None
 0.84A 4d7bA-2f28A:
undetectable		 4d7bA-2f28A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.39A 4i00A-2f28A:
21.2		 4i00A-2f28A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2f28 SIALIDASE 2
(Homo
sapiens) 		4 / 7 ASP A 336
THR A 296
GLN A 166
LEU A 165
 None
 0.93A 4ib4A-2f28A:
undetectable		 4ib4A-2f28A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.42A 4mwrA-2f28A:
21.0		 4mwrA-2f28A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.42A 4wa5A-2f28A:
5.7		 4wa5A-2f28A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 LEU A  54
GLY A  57
SER A  33
LEU A  28
SER A 129
 None
None
None
CL  A1001 (-4.0A)
None
 1.36A 4zbrA-2f28A:
undetectable		 4zbrA-2f28A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 9 ILE A 362
THR A 296
GLN A  71
LEU A  25
LEU A 337
 None
 1.35A 5fhzB-2f28A:
undetectable		 5fhzB-2f28A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 2f28 SIALIDASE 2
(Homo
sapiens) 		4 / 8 LEU A 337
ILE A 277
TYR A 310
LEU A 326
 None
 0.96A 5ieoA-2f28A:
2.3		 5ieoA-2f28A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ILE A 191
ASP A 215
THR A 216
VAL A 244
LEU A 240
 None
 1.23A 5jkvA-2f28A:
undetectable		 5jkvA-2f28A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 11 ILE A 191
ASP A 215
THR A 216
VAL A 244
LEU A 240
 None
 1.28A 5jkwA-2f28A:
undetectable		 5jkwA-2f28A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL6_A_ASDA601_1
(AROMATASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 9 ILE A 191
ASP A 215
THR A 216
VAL A 244
LEU A 240
 None
 1.31A 5jl6A-2f28A:
0.0		 5jl6A-2f28A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL7_A_ASDA601_1
(AROMATASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 10 ILE A 191
ASP A 215
THR A 216
VAL A 244
LEU A 240
 None
 1.24A 5jl7A-2f28A:
0.0		 5jl7A-2f28A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL9_A_ASDA601_1
(AROMATASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 9 ILE A 191
ASP A 215
THR A 216
VAL A 244
LEU A 240
 None
 1.22A 5jl9A-2f28A:
0.0		 5jl9A-2f28A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2f28 SIALIDASE 2
(Homo
sapiens) 		3 / 3 GLN A 371
THR A 368
ASP A 345
 None
 0.69A 5k9dA-2f28A:
undetectable		 5k9dA-2f28A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.42A 5l17A-2f28A:
10.0		 5l17A-2f28A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2f28 SIALIDASE 2
(Homo
sapiens) 		4 / 8 GLY A 351
ILE A 277
GLN A 273
ASP A 336
 None
 0.99A 5vlmH-2f28A:
undetectable		 5vlmH-2f28A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		4 / 6 GLY A 341
GLY A 343
PRO A 344
GLY A 346
 None
 0.73A 6ag0C-2f28A:
undetectable		 6ag0C-2f28A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		7 / 12 ARG A  21
ILE A  22
GLU A  39
GLU A 218
ARG A 237
ARG A 304
TYR A 334
 None
 0.44A 6ekuA-2f28A:
39.8		 6ekuA-2f28A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 2f28 SIALIDASE 2
(Homo
sapiens) 		4 / 6 GLN A 256
GLU A 257
ALA A 246
GLN A 247
 None
 1.39A 6f6jC-2f28A:
undetectable
6f6jD-2f28A:
undetectable		 6f6jC-2f28A:
23.00
6f6jD-2f28A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 2f28 SIALIDASE 2
(Homo
sapiens) 		5 / 12 LEU A 293
GLU A 225
VAL A 224
PRO A 315
GLU A 319
 None
 1.43A 6mn8A-2f28A:
undetectable		 6mn8A-2f28A:
19.96