SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f2a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		4 / 8 ALA B 163
LEU B 224
LEU B   9
ALA B 193
 None
 0.81A 1e7cA-2f2aB:
undetectable		 1e7cA-2f2aB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GYX_A_BEZA1077_0
(HYPOTHETICAL PROTEIN
YDCE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus;
Staphylococcus
aureus) 		4 / 7 ARG B  78
TYR A 195
PRO B 273
SER A 209
 None
 1.31A 1gyxA-2f2aB:
0.0
1gyxB-2f2aB:
0.0		 1gyxA-2f2aB:
9.25
1gyxB-2f2aB:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 10 ASN A 432
SER A 154
GLY A 130
ARG A 358
GLY A 131
 None
GLN  A 501 (-2.9A)
GLN  A 501 (-3.2A)
GLN  A 501 (-2.5A)
GLN  A 501 ( 4.5A)
 1.36A 1ho5B-2f2aA:
undetectable		 1ho5B-2f2aA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		5 / 12 GLY B 103
ILE B 118
PRO B  98
ILE B  99
ILE B  70
 None
 0.91A 1hshC-2f2aB:
undetectable		 1hshC-2f2aB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		5 / 8 GLY B 103
ILE B 118
PRO B  98
ILE B  99
ILE B  70
 None
 1.03A 1hshD-2f2aB:
undetectable		 1hshD-2f2aB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT C
(Staphylococcus
aureus;
Staphylococcus
aureus) 		5 / 12 GLU C   8
ILE C  35
ALA A 365
TYR A 374
GLU C  33
 None
 1.38A 1ki7A-2f2aC:
undetectable		 1ki7A-2f2aC:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		3 / 3 PHE A  99
TYR A 103
PRO A 101
 None
 1.12A 1mcnA-2f2aA:
undetectable
1mcnB-2f2aA:
undetectable
1mcnP-2f2aA:
undetectable		 1mcnA-2f2aA:
17.96
1mcnB-2f2aA:
17.96
1mcnP-2f2aA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 8 ASP A 125
GLY A 130
GLY A 153
GLY A 152
 None
GLN  A 501 (-3.2A)
None
None
 0.59A 1qzzA-2f2aA:
undetectable		 1qzzA-2f2aA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT C
(Staphylococcus
aureus;
Staphylococcus
aureus) 		4 / 8 THR B  37
LEU B  42
THR C  84
ASP B 140
 None
 0.83A 1uyuA-2f2aB:
undetectable		 1uyuA-2f2aB:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 SER A 440
ALA A 183
TYR A 185
GLY A 187
VAL A 276
 None
 1.24A 1vpoH-2f2aA:
undetectable
1vpoL-2f2aA:
undetectable		 1vpoH-2f2aA:
18.97
1vpoL-2f2aA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		3 / 3 GLY B 117
ASP B 156
ASN B 102
 None
 0.63A 1vq1A-2f2aB:
undetectable		 1vq1A-2f2aB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 5 PHE A 351
LEU A  96
MET A 129
SER A 154
 None
None
None
GLN  A 501 (-2.9A)
 1.06A 1wrlC-2f2aA:
undetectable		 1wrlC-2f2aA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 5 ASP A  37
GLY A  77
ALA A  32
ILE A  33
 None
 0.93A 2aofA-2f2aA:
undetectable		 2aofA-2f2aA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 5 GLY A  73
PRO A 168
VAL A 167
ILE A  29
 None
 0.89A 2aoiA-2f2aA:
undetectable		 2aoiA-2f2aA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus;
Staphylococcus
aureus) 		5 / 10 PHE A  99
TYR A 329
THR A  89
VAL A 204
GLY B  46
 None
 1.33A 2cp4A-2f2aA:
undetectable		 2cp4A-2f2aA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 8 ALA A 229
VAL A 246
PHE A 248
THR A 249
 None
 0.97A 2kotB-2f2aA:
undetectable		 2kotB-2f2aA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 LEU A 111
MET A  76
LEU A 118
MET A 108
 None
 1.28A 2kuhA-2f2aA:
undetectable		 2kuhA-2f2aA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		4 / 5 LEU B 375
ALA B 386
ILE B 385
SER B 382
 None
 1.16A 2othA-2f2aB:
undetectable		 2othA-2f2aB:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 8 THR A 429
PRO A 430
VAL A 431
ARG A 180
 None
 1.00A 2v32A-2f2aA:
undetectable
2v32B-2f2aA:
undetectable		 2v32A-2f2aA:
19.13
2v32B-2f2aA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 8 THR A 429
PRO A 430
VAL A 431
ARG A 180
 None
 0.99A 2v41C-2f2aA:
undetectable
2v41D-2f2aA:
undetectable		 2v41C-2f2aA:
19.13
2v41D-2f2aA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 8 THR A 429
PRO A 430
VAL A 431
ARG A 180
 None
 1.01A 2v41C-2f2aA:
undetectable
2v41D-2f2aA:
undetectable		 2v41C-2f2aA:
19.13
2v41D-2f2aA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 THR A 429
PRO A 430
VAL A 431
ARG A 180
 None
 1.01A 2v41E-2f2aA:
undetectable
2v41F-2f2aA:
undetectable		 2v41E-2f2aA:
19.13
2v41F-2f2aA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 THR A 429
PRO A 430
VAL A 431
ARG A 180
 None
 1.02A 2v41E-2f2aA:
undetectable
2v41F-2f2aA:
undetectable		 2v41E-2f2aA:
19.13
2v41F-2f2aA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		3 / 3 ASP A  68
THR A 106
GLU A 114
 None
 0.83A 2zifB-2f2aA:
undetectable		 2zifB-2f2aA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		4 / 7 GLU B 150
ARG B 120
GLU B 124
SER B  93
 MG  B 601 (-3.1A)
None
MG  B 601 (-2.5A)
None
 1.17A 2zt7A-2f2aB:
1.4		 2zt7A-2f2aB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 8 SER A 170
ALA A 160
CYH A 186
THR A 133
 None
 0.79A 3bpxA-2f2aA:
undetectable
3bpxB-2f2aA:
undetectable		 3bpxA-2f2aA:
13.73
3bpxB-2f2aA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 11 ALA A  51
ILE A  29
GLY A  73
PRO A 168
ILE A 119
 None
 1.05A 3ebzA-2f2aA:
undetectable		 3ebzA-2f2aA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 9 ALA A  51
GLY A  73
PRO A 168
VAL A 167
ILE A 119
 None
 1.19A 3em4B-2f2aA:
undetectable		 3em4B-2f2aA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 8 ASP A 174
GLY A 176
ASP A 211
GLY A 435
LEU A 436
 GLN  A 501 (-4.5A)
GLN  A 501 (-3.5A)
None
None
None
 1.33A 3em6A-2f2aA:
undetectable		 3em6A-2f2aA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		5 / 12 GLU B 286
ARG B 289
VAL B  56
ASP B 281
ILE B 280
 None
 1.41A 3jayA-2f2aB:
0.8		 3jayA-2f2aB:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		3 / 3 ASN A  81
ASP A 211
ARG A 357
 None
 0.86A 3k13C-2f2aA:
undetectable		 3k13C-2f2aA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 8 ASP B 274
SER A 208
PHE B 270
SER A 319
 None
 1.00A 3m0wE-2f2aB:
undetectable
3m0wF-2f2aB:
undetectable
3m0wG-2f2aB:
undetectable
3m0wH-2f2aB:
undetectable		 3m0wE-2f2aB:
13.93
3m0wF-2f2aB:
13.93
3m0wG-2f2aB:
13.93
3m0wH-2f2aB:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 9 ALA A  51
ILE A  29
GLY A  73
PRO A 168
ILE A 119
 None
 1.03A 3nu4A-2f2aA:
undetectable		 3nu4A-2f2aA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		4 / 8 LEU B 369
ALA B 395
THR B 362
GLY B 346
 None
 0.93A 3ny4A-2f2aB:
undetectable		 3ny4A-2f2aB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT C
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 SER B 137
VAL B 139
VAL C  91
LEU A 339
 None
 0.64A 3o14A-2f2aB:
undetectable		 3o14A-2f2aB:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		5 / 9 GLY B 103
ILE B 118
PRO B  98
ILE B  99
ILE B  70
 None
 0.98A 3s45A-2f2aB:
undetectable		 3s45A-2f2aB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 11 GLY A 130
GLY A 152
PRO A 151
PRO A 182
ASP A 425
 GLN  A 501 (-3.2A)
None
None
None
GLN  A 501 (-2.6A)
 1.39A 3t8nD-2f2aA:
0.0
3t8nF-2f2aA:
0.0		 3t8nD-2f2aA:
13.88
3t8nF-2f2aA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 THR A 106
PHE A 201
SER A 105
TYR A 103
SER A 199
 None
 1.48A 3u9fG-2f2aA:
undetectable
3u9fH-2f2aA:
undetectable		 3u9fG-2f2aA:
16.46
3u9fH-2f2aA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 GLY A 153
GLY A 130
TYR A 422
ASN A 424
ALA A 159
 None
GLN  A 501 (-3.2A)
None
None
None
 1.12A 3vywA-2f2aA:
undetectable		 3vywA-2f2aA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 GLY A 153
GLY A 130
TYR A 422
ASN A 424
ALA A 159
 None
GLN  A 501 (-3.2A)
None
None
None
 1.16A 3vywB-2f2aA:
undetectable		 3vywB-2f2aA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 GLY A 153
GLY A 130
TYR A 422
ASN A 424
ALA A 159
 None
GLN  A 501 (-3.2A)
None
None
None
 1.15A 3vywD-2f2aA:
undetectable		 3vywD-2f2aA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 5 HIS A 332
GLY A 326
TYR A 331
GLU A 335
 None
 1.30A 4ae1B-2f2aA:
undetectable		 4ae1B-2f2aA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT C
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 LEU C  18
ARG C  17
GLY A 362
SER A 318
 None
 0.97A 4cp3A-2f2aC:
undetectable
4cp3B-2f2aC:
undetectable		 4cp3A-2f2aC:
24.60
4cp3B-2f2aC:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 4 GLU A 316
ASP A 211
ARG A 323
THR A 175
 None
None
None
GLN  A 501 (-4.2A)
 1.35A 4ej1A-2f2aA:
0.8		 4ej1A-2f2aA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 GLY A 153
GLY A 131
MET A 421
ASN A 424
 None
GLN  A 501 ( 4.5A)
None
None
 0.88A 4fgkB-2f2aA:
undetectable		 4fgkB-2f2aA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 5 GLY A 153
GLY A 131
MET A 421
ASN A 424
 None
GLN  A 501 ( 4.5A)
None
None
 0.90A 4fglC-2f2aA:
undetectable		 4fglC-2f2aA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 GLY A 153
GLY A 131
MET A 421
ASN A 424
 None
GLN  A 501 ( 4.5A)
None
None
 0.86A 4fglD-2f2aA:
undetectable		 4fglD-2f2aA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 VAL A 226
PRO A 215
THR A 175
SER A 154
GLY A 177
 None
None
GLN  A 501 (-4.2A)
GLN  A 501 (-2.9A)
GLN  A 501 (-4.1A)
 1.46A 4hvcA-2f2aA:
undetectable		 4hvcA-2f2aA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 PHE A 248
GLU A 251
SER A 250
ARG A 197
 None
 1.45A 4k5jA-2f2aA:
undetectable
4k5jB-2f2aA:
undetectable		 4k5jA-2f2aA:
21.32
4k5jB-2f2aA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		4 / 8 LEU B 170
LEU B 295
ILE B 151
VAL B 179
 None
 0.75A 4klaA-2f2aB:
undetectable		 4klaA-2f2aB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		4 / 6 GLU B 150
ARG B 120
GLU B 124
SER B  93
 MG  B 601 (-3.1A)
None
MG  B 601 (-2.5A)
None
 1.11A 4kr3A-2f2aB:
2.1		 4kr3A-2f2aB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 8 PHE A  99
TYR A 329
THR A  89
VAL A 204
 None
 1.12A 4l4eA-2f2aA:
undetectable		 4l4eA-2f2aA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 8 PHE A  99
TYR A 329
THR A  89
VAL A 204
 None
 1.13A 4l4fA-2f2aA:
undetectable		 4l4fA-2f2aA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 8 ALA A  51
GLY A  73
PRO A 168
VAL A 167
ILE A 119
 None
 1.14A 4ll3A-2f2aA:
undetectable		 4ll3A-2f2aA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 9 ALA A  51
GLY A  73
PRO A 168
VAL A 167
ILE A 119
 None
 1.13A 4ll3B-2f2aA:
undetectable		 4ll3B-2f2aA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT C
(Staphylococcus
aureus) 		4 / 8 SER B 130
SER B 137
TYR B  83
ILE C  94
 None
 1.19A 4ms4A-2f2aB:
undetectable		 4ms4A-2f2aB:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 5 ASN A 223
PRO A 215
GLY A 190
ASP A 237
 None
 1.15A 4n48B-2f2aA:
undetectable		 4n48B-2f2aA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 VAL A 226
PRO A 215
THR A 175
SER A 154
GLY A 177
 None
None
GLN  A 501 (-4.2A)
GLN  A 501 (-2.9A)
GLN  A 501 (-4.1A)
 1.43A 4olfA-2f2aA:
undetectable		 4olfA-2f2aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus;
Staphylococcus
aureus) 		4 / 5 LEU B  48
ARG B  78
ARG A 323
THR A 106
 None
 1.34A 4p3qA-2f2aB:
undetectable		 4p3qA-2f2aB:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		4 / 6 THR B 255
GLU B 227
THR B 207
LEU B 257
 None
 1.03A 4pgfA-2f2aB:
undetectable		 4pgfA-2f2aB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		4 / 8 GLU B 262
ASP B 266
ASP B 265
TYR B  83
 None
 1.33A 4qb9D-2f2aB:
undetectable		 4qb9D-2f2aB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 11 HIS A 332
GLY A 326
SER A 346
TYR A 331
GLU A 335
 None
 1.36A 4rv6A-2f2aA:
undetectable		 4rv6A-2f2aA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 11 HIS A 332
GLY A 326
SER A 346
TYR A 331
GLU A 335
 None
 1.36A 4rv6B-2f2aA:
undetectable		 4rv6B-2f2aA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		4 / 6 GLU B 328
TYR B 303
LEU B 309
PHE B 327
 None
 1.17A 4twdD-2f2aB:
undetectable
4twdE-2f2aB:
undetectable		 4twdD-2f2aB:
20.13
4twdE-2f2aB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		4 / 6 GLU B 328
TYR B 303
LEU B 309
PHE B 327
 None
 1.20A 4twdF-2f2aB:
undetectable
4twdG-2f2aB:
undetectable		 4twdF-2f2aB:
20.13
4twdG-2f2aB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		4 / 6 GLU B 328
TYR B 303
LEU B 309
PHE B 327
 None
 1.17A 4twdI-2f2aB:
undetectable
4twdJ-2f2aB:
undetectable		 4twdI-2f2aB:
20.13
4twdJ-2f2aB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		3 / 3 VAL A 220
TYR A 466
ALA A 469
 None
 0.54A 4ybnA-2f2aA:
undetectable		 4ybnA-2f2aA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		3 / 3 SER B 172
GLU B 328
GLU B 306
 None
 0.86A 4ymgB-2f2aB:
undetectable		 4ymgB-2f2aB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 PRO A  22
VAL A  25
ILE A  29
ILE A  15
 None
 0.74A 5bmvC-2f2aA:
undetectable		 5bmvC-2f2aA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 SER A 231
ASP A 174
ARG A 180
GLY A 190
 None
GLN  A 501 (-4.5A)
None
None
 1.00A 5btfA-2f2aA:
undetectable
5btfC-2f2aA:
undetectable
5btfD-2f2aA:
undetectable		 5btfA-2f2aA:
21.97
5btfC-2f2aA:
21.97
5btfD-2f2aA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 SER A 231
ASP A 174
ARG A 180
GLY A 190
 None
GLN  A 501 (-4.5A)
None
None
 0.83A 5cdqA-2f2aA:
0.6
5cdqC-2f2aA:
undetectable
5cdqD-2f2aA:
undetectable		 5cdqA-2f2aA:
22.59
5cdqC-2f2aA:
22.59
5cdqD-2f2aA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		3 / 3 PRO B 147
ILE B 173
SER B  19
 None
 0.81A 5fsaA-2f2aB:
undetectable		 5fsaA-2f2aB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT C
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 ASP A 416
GLU C  24
SER C  21
GLU C  23
GLU A 354
 None
 1.47A 5iqeC-2f2aA:
0.0		 5iqeC-2f2aA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 SER A   7
ASN A  10
ASP A 480
GLU A   9
TYR A 470
 None
 1.18A 5iqeD-2f2aA:
0.0		 5iqeD-2f2aA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		5 / 12 LEU B 170
GLY B 103
MET B  68
ASN B  67
ALA B  62
 None
 1.15A 5kc4A-2f2aB:
undetectable		 5kc4A-2f2aB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		6 / 12 HIS A 479
VAL A 162
TYR A 482
VAL A 189
GLY A 190
ALA A 183
 None
 1.45A 5kirB-2f2aA:
undetectable		 5kirB-2f2aA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 ILE A  74
ILE A  15
LEU A  11
ALA A  51
LEU A  58
 None
 1.15A 5km9B-2f2aA:
undetectable		 5km9B-2f2aA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 5 GLU A 462
GLY A 196
SER A 231
GLY A 232
 None
 1.14A 5kprA-2f2aA:
undetectable		 5kprA-2f2aA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		4 / 5 THR B  37
ASN B 142
ASP B 140
LEU B 141
 None
 1.32A 5m0iB-2f2aB:
undetectable		 5m0iB-2f2aB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 MET A 191
GLY A 457
VAL A 431
GLN A 454
LEU A 259
 None
 1.24A 5ubbA-2f2aA:
undetectable		 5ubbA-2f2aA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		5 / 9 LEU B  15
ALA B  59
VAL B 288
MET B  60
GLY B 178
 None
 1.46A 5w5vA-2f2aB:
undetectable		 5w5vA-2f2aB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		5 / 10 VAL B 348
GLY B 347
GLU B 350
LEU B 344
ASN B 342
 None
 1.14A 5x6yB-2f2aB:
undetectable		 5x6yB-2f2aB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus;
Staphylococcus
aureus) 		3 / 3 TYR B  44
ARG A 328
THR B  37
 None
 0.89A 5z84J-2f2aB:
undetectable		 5z84J-2f2aB:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 VAL A 441
ILE A 439
VAL A 468
VAL A 280
LEU A 287
 None
 1.20A 6ajiA-2f2aA:
0.3		 6ajiA-2f2aA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 VAL A 441
LEU A 453
ILE A 439
VAL A 468
LEU A 287
 None
 1.16A 6ajiA-2f2aA:
0.3		 6ajiA-2f2aA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 SER A 250
ARG A 197
PHE A 248
GLU A 251
 None
 1.43A 6av7A-2f2aA:
undetectable
6av7B-2f2aA:
undetectable		 6av7A-2f2aA:
9.80
6av7B-2f2aA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 4 GLY A 435
ARG A 180
ASN A 432
LEU A 436
 None
 1.23A 6b58A-2f2aA:
undetectable		 6b58A-2f2aA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 LEU A 122
GLY A  73
LEU A 118
GLY A 120
 None
 0.79A 6eu9D-2f2aA:
undetectable		 6eu9D-2f2aA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Staphylococcus
aureus) 		5 / 12 ILE B 174
ALA B 163
LEU B 189
MET B 184
LEU B   9
 None
 1.32A 6ie8A-2f2aB:
undetectable		 6ie8A-2f2aB:
18.88