SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		5 / 12 ALA A  67
ILE A  66
ALA A 165
LEU A  89
MET A 158
 None
GOL  A 501 (-3.9A)
None
None
None
 1.32A 1udtA-2f2bA:
undetectable		 1udtA-2f2bA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		5 / 8 GLY A 133
GLY A 131
GLY A 130
ALA A  27
ILE A  44
 None
 1.05A 1yajC-2f2bA:
undetectable		 1yajC-2f2bA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		5 / 9 ALA A 122
ALA A 127
GLY A 130
GLY A 125
ILE A 124
 None
 1.27A 2v7bB-2f2bA:
undetectable		 2v7bB-2f2bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		5 / 9 ALA A 122
ALA A 127
GLY A 131
GLY A 125
ILE A 124
 None
 1.15A 2v7bB-2f2bA:
undetectable		 2v7bB-2f2bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		5 / 12 ALA A 149
GLY A 153
LEU A 148
GLY A 195
SER A 194
 None
 0.88A 3g2oA-2f2bA:
undetectable		 3g2oA-2f2bA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		5 / 12 ALA A 149
GLY A 153
LEU A 148
GLY A 195
SER A 194
 None
 0.89A 3g2oB-2f2bA:
undetectable		 3g2oB-2f2bA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		5 / 12 LEU A 157
PHE A 138
ILE A  66
ALA A  57
GLY A 191
 GOL  A 501 (-4.8A)
None
GOL  A 501 (-3.9A)
None
None
 1.08A 3nxuA-2f2bA:
undetectable		 3nxuA-2f2bA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		5 / 12 GLY A  50
GLY A  53
ALA A  33
ASN A  43
LEU A  48
 None
 1.24A 3vywB-2f2bA:
undetectable		 3vywB-2f2bA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		4 / 5 PHE A 138
ILE A  44
GLY A  45
THR A  29
 None
 1.03A 4ejjC-2f2bA:
undetectable		 4ejjC-2f2bA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		5 / 12 ALA A 111
GLY A  14
ILE A 161
THR A 160
LEU A 157
 None
None
None
None
GOL  A 501 (-4.8A)
 0.95A 4n49A-2f2bA:
undetectable		 4n49A-2f2bA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		4 / 8 ALA A 126
GLY A 133
LEU A 132
LEU A 119
 None
 0.89A 4po0A-2f2bA:
undetectable		 4po0A-2f2bA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		3 / 3 TRP A 144
ILE A 224
SER A 223
 None
 0.99A 5gqbA-2f2bA:
undetectable		 5gqbA-2f2bA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		4 / 7 PHE A  20
ILE A 117
GLY A 110
PHE A  16
 None
 0.90A 5h3aA-2f2bA:
undetectable		 5h3aA-2f2bA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		5 / 10 LEU A 157
ALA A 175
GLY A  74
VAL A  85
ILE A 161
 GOL  A 501 (-4.8A)
None
None
GOL  A 501 (-4.9A)
None
 1.02A 5kr1A-2f2bA:
undetectable		 5kr1A-2f2bA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		4 / 8 ILE A 161
LEU A 157
ILE A 179
ILE A  70
 None
GOL  A 501 (-4.8A)
GOL  A 501 ( 4.9A)
None
 0.72A 5numA-2f2bA:
undetectable		 5numA-2f2bA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		4 / 6 VAL A 183
THR A 182
LEU A  18
LEU A  73
 None
None
GOL  A 501 (-4.7A)
None
 0.88A 5tudD-2f2bA:
undetectable		 5tudD-2f2bA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		5 / 10 SER A  91
GLY A  88
ILE A 159
ALA A 236
LEU A 235
 None
 1.26A 5zjiA-2f2bA:
undetectable
5zjiJ-2f2bA:
undetectable		 5zjiA-2f2bA:
12.60
5zjiJ-2f2bA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2f2b AQUAPORIN AQPM
(Methanothermobac
ter
marburgensis) 		4 / 8 GLY A 131
VAL A  28
GLY A 205
SER A 115
 None
 0.79A 6hu9H-2f2bA:
undetectable
6hu9e-2f2bA:
undetectable		 6hu9H-2f2bA:
16.43
6hu9e-2f2bA:
20.25