SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f2f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 2f2f CYTOLETHAL
DISTENDING TOXIN C
(Aggregatibacter
actinomycetemcom
itans) 		4 / 4 ASP C 143
HIS C 139
ARG C 145
GLU C 147
 None
 1.05A 1lqtA-2f2fC:
undetectable		 1lqtA-2f2fC:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2f2f CYTOLETHAL
DISTENDING TOXIN C
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 GLY C  83
GLY C  82
ASP C 129
TYR C 162
GLY C 150
 None
 0.77A 1n2xB-2f2fC:
undetectable		 1n2xB-2f2fC:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 2f2f CYTOLETHAL
DISTENDING TOXIN C
(Aggregatibacter
actinomycetemcom
itans) 		4 / 8 ASN C  53
ARG C  39
GLU C  67
TYR C  56
 None
 1.09A 2fl5E-2f2fC:
undetectable
2fl5F-2f2fC:
undetectable		 2fl5E-2f2fC:
20.75
2fl5F-2f2fC:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 2f2f CYTOLETHAL
DISTENDING TOXIN C
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 LEU C 132
LEU C  79
ILE C 118
GLY C  83
LEU C  85
 None
 1.30A 2j7xA-2f2fC:
undetectable		 2j7xA-2f2fC:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 2f2f CYTOLETHAL
DISTENDING TOXIN C
(Aggregatibacter
actinomycetemcom
itans) 		5 / 11 LEU C 132
LEU C  79
ILE C 118
GLY C  83
LEU C  85
 None
 1.23A 4pxmB-2f2fC:
undetectable		 4pxmB-2f2fC:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 2f2f CYTOLETHAL
DISTENDING TOXIN C
(Aggregatibacter
actinomycetemcom
itans) 		4 / 6 TYR C  61
PRO C 168
LEU C 167
PHE C 170
 None
 1.12A 5tl8A-2f2fC:
undetectable		 5tl8A-2f2fC:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2f2f CYTOLETHAL
DISTENDING TOXIN C
(Aggregatibacter
actinomycetemcom
itans) 		3 / 3 LEU C 160
ASN C 121
LEU C 126
 None
 0.72A 6exiD-2f2fC:
undetectable		 6exiD-2f2fC:
24.09