SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster) 		4 / 7 THR X 422
SER X 429
GLY X 472
HIS X 473
 None
None
None
MLD  X 201 (-3.9A)
 0.91A 1gtnF-2f2lX:
undetectable
1gtnG-2f2lX:
undetectable		 1gtnF-2f2lX:
20.75
1gtnG-2f2lX:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster) 		4 / 7 THR X 422
SER X 429
GLY X 472
HIS X 473
 None
None
None
MLD  X 201 (-3.9A)
 0.98A 1gtnJ-2f2lX:
undetectable
1gtnK-2f2lX:
undetectable		 1gtnJ-2f2lX:
20.75
1gtnK-2f2lX:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster) 		6 / 12 GLY X 414
GLU X 411
GLY X 412
ASP X 416
GLY X 458
ASN X 359
 None
 1.44A 1n2xB-2f2lX:
undetectable		 1n2xB-2f2lX:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 2f2l PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LC
ISOFORM LCA
(Drosophila
melanogaster) 		5 / 9 LEU A 403
ASP A 407
ILE A 370
GLY A 438
ILE A 416
 None
 1.09A 2avoA-2f2lA:
undetectable		 2avoA-2f2lA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2f2l PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LC
ISOFORM LCA
PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster;
Drosophila
melanogaster) 		5 / 12 GLY X 436
ASN X 444
ARG X 441
ALA X 368
ALA A 363
 None
 1.21A 2br4B-2f2lX:
undetectable		 2br4B-2f2lX:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2f2l PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LC
ISOFORM LCA
(Drosophila
melanogaster) 		5 / 10 ILE A 381
LEU A 451
VAL A 377
GLY A 378
ARG A 490
 None
 1.03A 2wd9C-2f2lA:
undetectable		 2wd9C-2f2lA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster) 		5 / 12 HIS X 365
SER X 481
PHE X 438
LEU X 470
ILE X 490
 MLD  X 201 (-3.9A)
MLD  X 201 (-3.4A)
None
None
None
 1.19A 2xrlA-2f2lX:
undetectable		 2xrlA-2f2lX:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_0
(CATECHOL
O-METHYLTRANSFERASE)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster) 		5 / 12 VAL X 381
TYR X 410
CYH X 451
SER X 429
HIS X 421
 None
 1.42A 3a7eA-2f2lX:
0.9		 3a7eA-2f2lX:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster) 		4 / 4 SER X 429
GLY X 428
GLY X 431
GLY X 419
 None
 0.86A 3bogB-2f2lX:
undetectable
3bogD-2f2lX:
undetectable		 3bogB-2f2lX:
undetectable
3bogD-2f2lX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster) 		4 / 6 GLY X 405
GLU X 372
GLY X 370
ASN X 444
 None
 1.03A 3e9rA-2f2lX:
undetectable		 3e9rA-2f2lX:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster) 		4 / 6 GLY X 405
GLU X 372
GLY X 370
ASN X 444
 None
 1.04A 3e9rC-2f2lX:
undetectable		 3e9rC-2f2lX:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 2f2l PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LC
ISOFORM LCA
(Drosophila
melanogaster) 		5 / 9 LEU A 403
ASP A 407
ILE A 370
GLY A 438
ILE A 416
 None
 1.06A 3ekqB-2f2lA:
undetectable		 3ekqB-2f2lA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster) 		3 / 3 GLU X 369
GLY X 436
THR X 437
 None
 0.53A 3iazA-2f2lX:
undetectable		 3iazA-2f2lX:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LC
ISOFORM LCA
(Drosophila
melanogaster) 		4 / 5 GLN A 404
THR A 405
GLU X 480
HIS X 473
 None
MLD  X 201 (-4.1A)
None
MLD  X 201 (-3.9A)
 1.42A 3n58A-2f2lA:
undetectable		 3n58A-2f2lA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LC
ISOFORM LCA
(Drosophila
melanogaster) 		4 / 5 GLN A 404
THR A 405
GLU X 480
HIS X 473
 None
MLD  X 201 (-4.1A)
None
MLD  X 201 (-3.9A)
 1.42A 3n58C-2f2lA:
undetectable		 3n58C-2f2lA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LC
ISOFORM LCA
(Drosophila
melanogaster) 		4 / 4 GLN A 404
THR A 405
GLU X 480
HIS X 473
 None
MLD  X 201 (-4.1A)
None
MLD  X 201 (-3.9A)
 1.46A 3n58D-2f2lA:
undetectable		 3n58D-2f2lA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2f2l PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LC
ISOFORM LCA
PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster;
Drosophila
melanogaster) 		4 / 7 ILE A 456
LEU A 421
VAL X 383
SER X 386
 None
 1.00A 3r9vA-2f2lA:
undetectable
3r9vB-2f2lA:
undetectable		 3r9vA-2f2lA:
20.21
3r9vB-2f2lA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster) 		5 / 10 ALA X 450
VAL X 409
TYR X 399
ILE X 432
ILE X 435
 None
None
MLD  X 201 (-4.6A)
None
None
 1.24A 3retA-2f2lX:
undetectable
3retB-2f2lX:
undetectable		 3retA-2f2lX:
20.11
3retB-2f2lX:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster) 		3 / 3 ASP X 406
SER X 378
TYR X 410
 None
 0.92A 5glmA-2f2lX:
undetectable		 5glmA-2f2lX:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster) 		3 / 3 GLU X 485
TYR X 487
ARG X 474
 None
 0.82A 5uunA-2f2lX:
undetectable		 5uunA-2f2lX:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster) 		4 / 4 LEU X 486
GLY X 483
SER X 481
SER X 364
 None
None
MLD  X 201 (-3.4A)
MLD  X 201 ( 3.9A)
 1.33A 5uunA-2f2lX:
undetectable		 5uunA-2f2lX:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster) 		3 / 3 GLU X 485
TYR X 487
ARG X 474
 None
 0.81A 5uunB-2f2lX:
undetectable		 5uunB-2f2lX:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX
(Drosophila
melanogaster) 		4 / 4 LEU X 486
GLY X 483
SER X 481
SER X 364
 None
None
MLD  X 201 (-3.4A)
MLD  X 201 ( 3.9A)
 1.30A 5uunB-2f2lX:
undetectable		 5uunB-2f2lX:
21.75