SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f37'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Homo
sapiens) 		4 / 6 LEU A 167
ILE A 169
GLU A 172
PRO A 212
 None
 1.21A 1ditH-2f37A:
undetectable
1ditP-2f37A:
undetectable		 1ditH-2f37A:
21.19
1ditP-2f37A:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Homo
sapiens) 		5 / 12 TYR A 207
ASP A 242
SER A 243
GLN A 244
GLU A 210
 None
 1.38A 1dy4A-2f37A:
undetectable		 1dy4A-2f37A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Homo
sapiens) 		4 / 6 ALA A 166
LEU A 139
ASP A 142
LEU A 105
 None
 0.88A 1mt1D-2f37A:
undetectable
1mt1E-2f37A:
undetectable		 1mt1D-2f37A:
17.65
1mt1E-2f37A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Homo
sapiens) 		5 / 9 GLY A 277
LEU A 274
TYR A 270
LEU A 252
THR A 247
 None
 1.08A 2npnA-2f37A:
undetectable		 2npnA-2f37A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Homo
sapiens) 		4 / 5 LEU A 238
ALA A 236
LEU A 228
MET A 269
 None
 1.17A 2oaxA-2f37A:
undetectable		 2oaxA-2f37A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Homo
sapiens) 		4 / 7 VAL A 183
VAL A 179
LEU A 176
SER A 175
 None
 0.74A 3hs6B-2f37A:
undetectable		 3hs6B-2f37A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Homo
sapiens) 		4 / 7 VAL A 152
VAL A 189
ASN A 185
GLY A 186
 None
 1.03A 3kmoB-2f37A:
undetectable		 3kmoB-2f37A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Homo
sapiens) 		4 / 6 ALA A 236
GLN A 234
LEU A 213
LEU A 167
 None
 1.17A 4xoyA-2f37A:
undetectable		 4xoyA-2f37A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Homo
sapiens) 		4 / 6 ALA A 236
GLN A 234
LEU A 213
LEU A 167
 None
 1.22A 4xp3A-2f37A:
undetectable		 4xp3A-2f37A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Homo
sapiens) 		5 / 6 LEU A 182
ALA A 170
LEU A 151
SER A 165
THR A 118
 None
 1.47A 6f88B-2f37A:
undetectable		 6f88B-2f37A:
14.17