SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		3 / 3 LEU A 101
SER A  20
ASN A  71
 None
 0.68A 1bx4A-2f3oA:
undetectable		 1bx4A-2f3oA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 8 ARG A  18
LEU A  69
GLY A  83
ILE A  86
ILE A  76
 None
 1.23A 1d4yB-2f3oA:
undetectable		 1d4yB-2f3oA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  93
ILE A  87
ARG A 112
LEU A 111
ILE A  77
 None
 0.87A 1dhiA-2f3oA:
undetectable		 1dhiA-2f3oA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 11 LEU A  93
ILE A  87
ARG A 112
LEU A 111
ILE A  77
 None
 0.91A 1dhiB-2f3oA:
undetectable		 1dhiB-2f3oA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  93
ILE A  87
ARG A 112
LEU A 111
ILE A  77
 None
 0.90A 1draB-2f3oA:
undetectable		 1draB-2f3oA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  93
ILE A  87
ARG A 112
LEU A 111
ILE A  77
 None
 0.88A 1drbA-2f3oA:
undetectable		 1drbA-2f3oA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  93
ILE A  87
ARG A 112
LEU A 111
ILE A  77
 None
 0.92A 1drbB-2f3oA:
undetectable		 1drbB-2f3oA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 5 ARG A 372
ALA A 347
ASP A 401
GLY A 344
 None
 0.97A 1e7bA-2f3oA:
undetectable		 1e7bA-2f3oA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 5 ARG A 372
ALA A 347
ASP A 401
GLY A 344
 None
 1.00A 1e7cA-2f3oA:
undetectable		 1e7cA-2f3oA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 9 VAL A 254
LEU A 282
ILE A 295
ALA A 300
LEU A 304
 None
 1.17A 1eqgA-2f3oA:
undetectable		 1eqgA-2f3oA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 5 HIS A 155
GLU A 428
ALA A 430
SER A 435
 GOL  A 778 (-4.3A)
GOL  A 778 (-2.8A)
None
None
 1.39A 1errA-2f3oA:
undetectable
1errB-2f3oA:
undetectable		 1errA-2f3oA:
15.34
1errB-2f3oA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 587
LEU A 586
SER A 647
LEU A 645
GLU A 653
 None
 1.25A 1kw0A-2f3oA:
undetectable		 1kw0A-2f3oA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 11 ILE A  54
LEU A  51
HIS A 265
TRP A 258
GLY A  66
 None
 1.35A 1kyvA-2f3oA:
undetectable
1kyvB-2f3oA:
undetectable		 1kyvA-2f3oA:
13.36
1kyvB-2f3oA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 4 ILE A 555
LEU A 552
VAL A 548
ALA A 542
 None
 0.86A 1mz9A-2f3oA:
undetectable		 1mz9A-2f3oA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 5 ILE A 555
LEU A 552
VAL A 548
ALA A 542
 None
 0.88A 1mz9C-2f3oA:
undetectable		 1mz9C-2f3oA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		3 / 3 GLU A  80
TRP A 119
LYS A 310
 None
 1.15A 1qu2A-2f3oA:
undetectable		 1qu2A-2f3oA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 6 LEU A  93
GLU A 323
LEU A  90
VAL A  82
 None
 1.19A 1sn5A-2f3oA:
undetectable		 1sn5A-2f3oA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 7 PHE A  78
LEU A  47
VAL A  50
ILE A  76
 None
 0.97A 1t87B-2f3oA:
undetectable		 1t87B-2f3oA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 8 ARG A 770
ASN A 726
ARG A 734
VAL A 768
 None
 1.01A 1u1jA-2f3oA:
undetectable		 1u1jA-2f3oA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 5 VAL A 446
ASN A 445
VAL A 548
ILE A 545
 None
 0.95A 1z2bC-2f3oA:
undetectable		 1z2bC-2f3oA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 680
LEU A 607
GLY A 549
ASP A 550
ALA A 598
 None
 1.21A 2bm9B-2f3oA:
undetectable		 2bm9B-2f3oA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 8 TYR A 630
SER A 439
TYR A 269
HIS A 155
 None
GOL  A 778 ( 4.3A)
None
GOL  A 778 (-4.3A)
 1.33A 2bteD-2f3oA:
undetectable		 2bteD-2f3oA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 11 GLY A 142
SER A 143
PHE A 641
GLN A 324
ASP A 319
 None
 1.39A 2c2bE-2f3oA:
1.2
2c2bF-2f3oA:
0.0		 2c2bE-2f3oA:
21.37
2c2bF-2f3oA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 5 ARG A 649
THR A 642
LEU A 460
ALA A 644
 None
 1.15A 2e1qD-2f3oA:
undetectable		 2e1qD-2f3oA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 7 THR A 634
ALA A 151
TYR A 269
PHE A 318
 None
PGE  A 777 ( 3.7A)
None
None
 1.12A 2hzqA-2f3oA:
undetectable		 2hzqA-2f3oA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 5 LEU A 746
VAL A 371
LEU A 398
ARG A 384
 None
 0.96A 2oiqA-2f3oA:
undetectable		 2oiqA-2f3oA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 11 LEU A 645
LEU A 479
THR A 470
VAL A 606
TRP A 609
 None
 1.28A 2qd3A-2f3oA:
undetectable		 2qd3A-2f3oA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 303
LEU A 164
PHE A 285
PHE A 250
LEU A 351
 None
 1.02A 2w3bA-2f3oA:
undetectable		 2w3bA-2f3oA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 303
LEU A 164
PHE A 285
PHE A 250
LEU A 351
 None
 1.04A 2w3bB-2f3oA:
undetectable		 2w3bB-2f3oA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 303
LEU A 164
PHE A 285
PHE A 250
LEU A 351
 None
 1.06A 2w3mA-2f3oA:
undetectable		 2w3mA-2f3oA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 303
LEU A 164
PHE A 285
PHE A 250
LEU A 351
 None
 1.03A 2w3mB-2f3oA:
undetectable		 2w3mB-2f3oA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 277
GLY A 276
SER A 439
 None
None
GOL  A 778 ( 4.3A)
 0.54A 2xctB-2f3oA:
undetectable		 2xctB-2f3oA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 4 ILE A 238
ARG A 229
ILE A 235
THR A 249
 None
 1.10A 3ia4C-2f3oA:
undetectable		 3ia4C-2f3oA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		3 / 3 GLU A  29
GLU A  52
ASN A  53
 None
 0.89A 3lp9B-2f3oA:
undetectable
3lp9D-2f3oA:
undetectable		 3lp9B-2f3oA:
16.46
3lp9D-2f3oA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		3 / 3 SER A 773
ASP A 666
ASN A 594
 None
 0.82A 3lsfB-2f3oA:
undetectable
3lsfE-2f3oA:
undetectable		 3lsfB-2f3oA:
17.65
3lsfE-2f3oA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 666
ASN A 594
SER A 773
 None
 0.82A 3lsfB-2f3oA:
undetectable
3lsfE-2f3oA:
undetectable		 3lsfB-2f3oA:
17.65
3lsfE-2f3oA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		3 / 3 SER A 651
SER A 643
HIS A 583
 None
 0.53A 3mzeA-2f3oA:
undetectable		 3mzeA-2f3oA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 7 ARG A 770
ILE A 769
LEU A 760
THR A 692
 None
 1.09A 3nxuA-2f3oA:
undetectable		 3nxuA-2f3oA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 7 ASP A 527
VAL A 156
ILE A 273
SER A 515
 None
 0.94A 3pglA-2f3oA:
undetectable		 3pglA-2f3oA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 THR A 437
PHE A 537
SER A 435
TYR A 535
ALA A 418
 None
 1.39A 3u9fG-2f3oA:
undetectable
3u9fH-2f3oA:
undetectable		 3u9fG-2f3oA:
15.08
3u9fH-2f3oA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 9 LEU A 450
ARG A 649
THR A 642
LEU A 460
ALA A 644
 None
 1.18A 3unaA-2f3oA:
0.0		 3unaA-2f3oA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 9 LEU A 450
ARG A 649
THR A 642
LEU A 460
ALA A 644
 None
 1.19A 3unaB-2f3oA:
0.0		 3unaB-2f3oA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 680
LEU A 398
LEU A 718
GLY A 719
ILE A 674
 None
 1.03A 3uwlD-2f3oA:
undetectable		 3uwlD-2f3oA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 8 TRP A 258
LEU A 307
MET A 275
TYR A 160
 None
 1.35A 3zmdA-2f3oA:
undetectable
3zmdB-2f3oA:
undetectable		 3zmdA-2f3oA:
10.75
3zmdB-2f3oA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 303
LEU A 164
PHE A 285
PHE A 250
LEU A 351
 None
 1.09A 4kebB-2f3oA:
undetectable		 4kebB-2f3oA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 303
LEU A 164
PHE A 285
PHE A 250
LEU A 351
 None
 1.06A 4kfjB-2f3oA:
undetectable		 4kfjB-2f3oA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 124
ASP A 134
ARG A 496
LEU A 139
ILE A 150
 None
None
None
PGE  A 777 ( 4.9A)
PGE  A 777 ( 4.7A)
 1.05A 4m2xE-2f3oA:
undetectable		 4m2xE-2f3oA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 303
LEU A 164
PHE A 285
PHE A 250
LEU A 351
 None
 1.07A 4m6kA-2f3oA:
undetectable		 4m6kA-2f3oA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 7 ASP A 440
THR A 148
SER A 438
HIS A 155
 GOL  A 778 (-4.0A)
PGE  A 777 ( 4.4A)
None
GOL  A 778 (-4.3A)
 1.42A 4o4dA-2f3oA:
undetectable		 4o4dA-2f3oA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		3 / 3 ALA A 330
GLN A 541
GLY A 628
 GOL  A 778 (-3.3A)
None
None
 0.61A 4odoC-2f3oA:
undetectable		 4odoC-2f3oA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_1
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 GLU A 451
ALA A 447
ASP A 547
ASN A 445
LYS A 448
 None
 1.36A 4uacA-2f3oA:
0.0		 4uacA-2f3oA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		3 / 3 MET A 275
GLN A 271
TYR A 269
 None
GOL  A 778 (-3.8A)
None
 0.98A 4udcA-2f3oA:
undetectable		 4udcA-2f3oA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 11 SER A 754
LEU A 364
ASP A 360
VAL A 369
ILE A 389
 None
 1.30A 4uuuB-2f3oA:
undetectable		 4uuuB-2f3oA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 7 SER A 502
SER A 438
PHE A 625
GLU A 149
 None
 1.25A 4xzkA-2f3oA:
undetectable		 4xzkA-2f3oA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  93
ILE A  87
ARG A 112
LEU A 111
ILE A  77
 None
 0.83A 5eajA-2f3oA:
undetectable		 5eajA-2f3oA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 8 GLN A 541
ASP A 424
GLY A 539
THR A 437
 None
 0.83A 5hwaA-2f3oA:
undetectable		 5hwaA-2f3oA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 314
GLY A  74
HIS A 265
GLU A 267
ILE A  54
 None
 1.42A 5igwA-2f3oA:
undetectable		 5igwA-2f3oA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 314
HIS A 265
THR A 511
GLU A 267
ILE A  54
 None
 1.44A 5iwuA-2f3oA:
undetectable		 5iwuA-2f3oA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 THR A 331
ALA A 272
SER A 327
GLY A 328
THR A 633
 None
GOL  A 778 ( 4.2A)
None
None
None
 1.17A 5lf7V-2f3oA:
undetectable
5lf7b-2f3oA:
undetectable		 5lf7V-2f3oA:
17.25
5lf7b-2f3oA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 THR A 331
ALA A 272
SER A 327
GLY A 328
THR A 633
 None
GOL  A 778 ( 4.2A)
None
None
None
 1.17A 5lf7H-2f3oA:
undetectable
5lf7N-2f3oA:
undetectable		 5lf7H-2f3oA:
17.25
5lf7N-2f3oA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 5 ASN A 420
ASP A 417
ASP A 520
ASN A 159
 None
 1.46A 5vooA-2f3oA:
undetectable		 5vooA-2f3oA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 5 ASN A 420
ASP A 417
ASP A 520
ASN A 159
 None
 1.44A 5vooC-2f3oA:
undetectable		 5vooC-2f3oA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 11 GLU A 613
GLY A 628
ALA A 627
ALA A 542
ILE A 545
 None
 1.19A 5yk2A-2f3oA:
0.2		 5yk2A-2f3oA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		3 / 3 TYR A 602
ALA A 558
LEU A 559
 None
 0.69A 6ag0C-2f3oA:
undetectable		 6ag0C-2f3oA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 7 ARG A 165
ARG A 166
LEU A 163
GLN A 261
 None
 1.31A 6b89A-2f3oA:
1.5		 6b89A-2f3oA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 6 PHE A 381
ILE A 373
ASN A 374
ASP A 346
 None
 1.23A 6dhbA-2f3oA:
undetectable		 6dhbA-2f3oA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 10 SER A 676
LEU A 711
LEU A 691
ILE A 776
GLY A 669
 None
 1.28A 6dm0B-2f3oA:
3.0
6dm0C-2f3oA:
undetectable		 6dm0B-2f3oA:
8.27
6dm0C-2f3oA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 4 ASP A 107
ILE A 115
PRO A  79
LEU A 111
 None
 1.49A 6mkeB-2f3oA:
undetectable		 6mkeB-2f3oA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 680
LEU A 398
LEU A 718
GLY A 719
ILE A 674
 None
 1.05A 6qxsB-2f3oA:
undetectable		 6qxsB-2f3oA:
18.77