SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f46'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJ3_B_GBNB914_1 (BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE)	2f46	HYPOTHETICAL PROTEIN (Neisseria meningitidis)	5 / 10	PHE A 146 GLY A 111 GLY A 140 ALA A 136 ALA A 139	None	1.08A	2ej3B-2f46A: undetectable	2ej3B-2f46A: 20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H0A_A_9RAA500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	2f46	HYPOTHETICAL PROTEIN (Neisseria meningitidis)	5 / 12	ALA A 136 ALA A 139 VAL A 90 ILE A 85 LEU A 150	None	0.88A	3h0aA-2f46A: undetectable	3h0aA-2f46A: 21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ROD_D_NCAD302_0 (NICOTINAMIDE N-METHYLTRANSFERASE)	2f46	HYPOTHETICAL PROTEIN (Neisseria meningitidis)	4 / 7	ASP A 59 ALA A 61 ASP A 51 TYR A 107	None None CL A 156 (-4.5A) None	1.16A	3rodD-2f46A: undetectable	3rodD-2f46A: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IJI_H_BEZH501_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN YIBF)	2f46	HYPOTHETICAL PROTEIN (Neisseria meningitidis)	4 / 7	ALA A 124 VAL A 90 ARG A 94 ARG A 121	None	1.06A	4ijiH-2f46A: undetectable	4ijiH-2f46A: 23.33

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2EJ3_B_GBNB914_1","BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE","2f46","HYPOTHETICAL PROTEIN","Neisseria meningitidis",5,"PHE A 146;GLY A 111;GLY A 140;ALA A 136;ALA A 139","None","1.08A","2ej3B-2f46A:undetectable","2ej3B-2f46A:20.53"],["3H0A_A_9RAA500_1","RETINOIC ACID RECEPTOR RXR-ALPHA","2f46","HYPOTHETICAL PROTEIN","Neisseria meningitidis",5,"ALA A 136;ALA A 139;VAL A  90;ILE A  85;LEU A 150","None","0.88A","3h0aA-2f46A:undetectable","3h0aA-2f46A:21.19"],["3ROD_D_NCAD302_0","NICOTINAMIDE N-METHYLTRANSFERASE","2f46","HYPOTHETICAL PROTEIN","Neisseria meningitidis",4,"ASP A  59;ALA A  61;ASP A  51;TYR A 107","None;None; CL A 156 (-4.5A);None","1.16A","3rodD-2f46A:undetectable","3rodD-2f46A:21.51"],["4IJI_H_BEZH501_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN YIBF","2f46","HYPOTHETICAL PROTEIN","Neisseria meningitidis",4,"ALA A 124;VAL A  90;ARG A  94;ARG A 121","None","1.06A","4ijiH-2f46A:undetectable","4ijiH-2f46A:23.33"]]