SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 1.01A 1d1gA-2f4iA:
undetectable		 1d1gA-2f4iA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 0.99A 1d1gB-2f4iA:
undetectable		 1d1gB-2f4iA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 11 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 1.02A 1dhiB-2f4iA:
undetectable		 1dhiB-2f4iA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 0.99A 1draB-2f4iA:
undetectable		 1draB-2f4iA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 0.99A 1ra2A-2f4iA:
undetectable		 1ra2A-2f4iA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 1.03A 1ra3A-2f4iA:
undetectable		 1ra3A-2f4iA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 1.00A 1rb2A-2f4iA:
undetectable		 1rb2A-2f4iA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 1.01A 1rd7A-2f4iA:
undetectable		 1rd7A-2f4iA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 0.98A 1rx2A-2f4iA:
undetectable		 1rx2A-2f4iA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 10 LEU A 125
GLY A 180
ILE A 213
VAL A 112
ILE A 110
 None
None
None
MLY  A 113 ( 2.9A)
None
 0.96A 1sdtA-2f4iA:
undetectable		 1sdtA-2f4iA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 1.04A 2drcB-2f4iA:
undetectable		 2drcB-2f4iA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 9 LEU A 125
GLY A 180
ILE A 213
VAL A 112
ILE A 110
 None
None
None
MLY  A 113 ( 2.9A)
None
 0.97A 2o4pB-2f4iA:
undetectable		 2o4pB-2f4iA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		4 / 7 THR A 138
ILE A 140
GLY A 139
PHE A 152
 None
MLY  A  51 ( 4.9A)
None
MLY  A 142 ( 4.3A)
 0.84A 2y7wC-2f4iA:
undetectable		 2y7wC-2f4iA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 1.02A 3drcB-2f4iA:
undetectable		 3drcB-2f4iA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 11 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 1.06A 3hbbC-2f4iA:
undetectable		 3hbbC-2f4iA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 1.01A 3tq9A-2f4iA:
undetectable		 3tq9A-2f4iA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 11 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 1.01A 3tqbA-2f4iA:
undetectable		 3tqbA-2f4iA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 1.01A 4dfrB-2f4iA:
undetectable		 4dfrB-2f4iA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		4 / 7 ALA A 141
PHE A 146
ALA A 156
LEU A  48
 MLY  A 142 ( 3.1A)
MLY  A 142 ( 4.3A)
None
None
 0.85A 4du2A-2f4iA:
undetectable		 4du2A-2f4iA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 1.04A 4kjlA-2f4iA:
undetectable		 4kjlA-2f4iA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 0.99A 4pstA-2f4iA:
undetectable		 4pstA-2f4iA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 0.97A 4pthA-2f4iA:
undetectable		 4pthA-2f4iA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 1.01A 4x5gB-2f4iA:
undetectable		 4x5gB-2f4iA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		4 / 7 VAL A  99
GLN A 214
LEU A 185
SER A 184
 None
 1.02A 4zphA-2f4iA:
undetectable
4zphB-2f4iA:
undetectable		 4zphA-2f4iA:
18.73
4zphB-2f4iA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 VAL A 167
GLU A 166
LEU A  60
ARG A  46
LEU A 159
 None
 1.15A 5nd7B-2f4iA:
undetectable		 5nd7B-2f4iA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 0.97A 5z6jA-2f4iA:
undetectable		 5z6jA-2f4iA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 0.98A 5z6kA-2f4iA:
undetectable		 5z6kA-2f4iA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		4 / 7 PHE A 146
GLY A 139
VAL A 163
LEU A 159
 MLY  A 142 ( 4.3A)
None
MLY  A 164 ( 3.1A)
None
 0.79A 6dwnB-2f4iA:
undetectable		 6dwnB-2f4iA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2f4i HYPOTHETICAL PROTEIN
TM0957
(Thermotoga
maritima) 		5 / 12 ALA A 137
ILE A 204
LEU A 123
ILE A  96
THR A 138
 None
MLY  A 201 ( 4.6A)
None
None
None
 1.07A 7dfrA-2f4iA:
undetectable		 7dfrA-2f4iA:
19.29