SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 GLU A  32
GLN A  28
LYS A   2
VAL A   3
 None
 1.45A 1l2iB-2f4lA:
undetectable		 1l2iB-2f4lA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 11 VAL A 128
GLY A 127
VAL A 196
ILE A 198
VAL A  69
 None
 1.14A 1phgA-2f4lA:
undetectable		 1phgA-2f4lA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 GLY A 172
GLY A 124
GLU A  32
PRO A  51
ALA A  36
 None
None
None
None
ZN  A1400 ( 3.9A)
 0.97A 1vq1B-2f4lA:
undetectable		 1vq1B-2f4lA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 TYR A 280
ARG A 243
ILE A 281
ASP A 214
 None
 1.11A 2xytH-2f4lA:
undetectable		 2xytH-2f4lA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 VAL A 156
GLY A 124
VAL A 125
VAL A  69
ILE A  71
 None
 1.03A 3oxvB-2f4lA:
undetectable		 3oxvB-2f4lA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 11 VAL A 156
GLY A 124
VAL A 125
VAL A  69
ILE A  71
 None
 1.03A 3oxvD-2f4lA:
undetectable		 3oxvD-2f4lA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 GLY A  64
GLY A 166
VAL A 200
ALA A 129
PHE A  57
 None
 1.16A 3qowA-2f4lA:
undetectable		 3qowA-2f4lA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 11 GLY A  60
ALA A 167
GLY A 166
VAL A 200
VAL A  23
 None
 1.29A 4c5lA-2f4lA:
undetectable		 4c5lA-2f4lA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 9 GLY A  60
ALA A 167
GLY A 166
VAL A 200
VAL A  23
 None
 1.18A 4c5lB-2f4lA:
undetectable		 4c5lB-2f4lA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 GLY A  60
ALA A 167
GLY A 166
VAL A 200
VAL A  23
 None
 1.26A 4c5lC-2f4lA:
undetectable		 4c5lC-2f4lA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 GLY A  60
ALA A 167
GLY A 166
VAL A 200
VAL A  23
 None
 1.21A 4c5lD-2f4lA:
undetectable		 4c5lD-2f4lA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 GLY A  60
ALA A 167
GLY A 166
VAL A 200
VAL A  23
 None
 1.19A 4c5nB-2f4lA:
undetectable		 4c5nB-2f4lA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 GLY A  92
GLY A  87
VAL A  95
HIS A  99
VAL A 185
 None
 1.29A 4c5nB-2f4lA:
undetectable		 4c5nB-2f4lA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 GLY A  60
ALA A 167
GLY A 166
VAL A 200
VAL A  23
 None
 1.35A 4c5nD-2f4lA:
undetectable		 4c5nD-2f4lA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 GLY A  54
PRO A  55
LEU A 169
VAL A  56
 None
 0.90A 4dubB-2f4lA:
undetectable		 4dubB-2f4lA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 9 GLU A 235
ILE A 277
ALA A 251
ALA A 255
ILE A 240
 None
 1.06A 4lbgB-2f4lA:
undetectable		 4lbgB-2f4lA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2f4l ACETAMIDASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 THR A 272
LEU A 160
LYS A  68
GLU A 204
 None
 1.04A 5tudA-2f4lA:
undetectable		 5tudA-2f4lA:
20.52