SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f4n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		4 / 7 ASP A 179
PHE A 181
ASN A 183
SER A 236
 None
 0.77A 1rqpB-2f4nA:
22.7		 1rqpB-2f4nA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A 179
PHE A 181
ASN A 183
SER A 236
 None
 0.81A 1rqpC-2f4nA:
23.1		 1rqpC-2f4nA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A 179
PHE A 181
ASN A 183
SER A 236
 None
 0.75A 1rqpA-2f4nA:
22.9		 1rqpA-2f4nA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A  70
LEU A  67
ILE A  55
HIS A  53
MET A  31
 None
 1.24A 1xzxX-2f4nA:
undetectable		 1xzxX-2f4nA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  71
LEU A  67
ILE A  55
HIS A  53
MET A  31
 None
 1.13A 1xzxX-2f4nA:
undetectable		 1xzxX-2f4nA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		4 / 8 ARG A 131
ALA A 149
GLU A 150
VAL A  80
 None
 0.91A 2bxgA-2f4nA:
undetectable		 2bxgA-2f4nA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A  64
VAL A 166
ASP A 108
GLY A  63
ILE A  60
 None
 1.29A 2dcfA-2f4nA:
undetectable		 2dcfA-2f4nA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A 179
PHE A 181
ASN A 183
SER A 236
 None
 0.73A 2v7uA-2f4nA:
8.4		 2v7uA-2f4nA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		4 / 7 ASP A 179
PHE A 181
ASN A 183
SER A 236
 None
 0.74A 2v7uB-2f4nA:
22.7		 2v7uB-2f4nA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A  64
VAL A 166
ASP A 108
GLY A  63
ILE A  60
 None
 1.24A 3a65A-2f4nA:
undetectable		 3a65A-2f4nA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 203
ILE A 215
PHE A 230
VAL A 255
 None
 0.72A 4ac9C-2f4nA:
3.1		 4ac9C-2f4nA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 203
ILE A 215
PHE A 230
VAL A 255
 None
 0.76A 4acaC-2f4nA:
3.0		 4acaC-2f4nA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 203
ILE A 215
PHE A 230
VAL A 255
 None
 0.74A 4acbC-2f4nA:
3.0		 4acbC-2f4nA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		5 / 7 ALA A 116
ALA A  64
ILE A  60
GLY A 110
ILE A 168
 None
 0.89A 4eatA-2f4nA:
undetectable		 4eatA-2f4nA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 116
ALA A  64
ILE A  60
GLY A 110
ILE A 168
 None
 0.87A 4eatB-2f4nA:
undetectable		 4eatB-2f4nA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A  46
GLY A 148
ALA A 149
GLU A 150
 None
 0.80A 4r1zB-2f4nA:
undetectable		 4r1zB-2f4nA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC404_0
(PROTON-GATED ION
CHANNEL)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		4 / 4 ILE A 151
ILE A 125
ARG A 123
TYR A 103
 None
 1.15A 4zzbC-2f4nA:
undetectable		 4zzbC-2f4nA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		4 / 4 ILE A 151
ARG A 123
TYR A 103
GLU A  97
 None
 1.00A 4zzbD-2f4nA:
undetectable		 4zzbD-2f4nA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_C_ACTC407_0
(PROTON-GATED ION
CHANNEL)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		4 / 4 ILE A 151
ILE A 125
ARG A 123
TYR A 103
 None
 1.22A 4zzcC-2f4nA:
undetectable		 4zzcC-2f4nA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_D_ACTD406_0
(PROTON-GATED ION
CHANNEL)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		4 / 4 ILE A 151
ILE A 125
ARG A 123
TYR A 103
 None
 1.23A 4zzcD-2f4nA:
0.0		 4zzcD-2f4nA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		5 / 5 ILE A 151
ILE A 125
ARG A 123
TYR A 103
GLU A  97
 None
 1.13A 4zzcE-2f4nA:
undetectable		 4zzcE-2f4nA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		3 / 3 PHE A  74
ILE A  14
ASP A   9
 None
 0.60A 5cswA-2f4nA:
undetectable		 5cswA-2f4nA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2f4n HYPOTHETICAL PROTEIN
MJ1651
(Methanocaldococc
us
jannaschii) 		3 / 3 PHE A  74
ILE A  14
ASP A   9
 None
 0.66A 5cswB-2f4nA:
undetectable		 5cswB-2f4nA:
22.80