SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 8 CYH A 283
CYH A 247
GLY A 251
GLY A 252
 ZN  A 501 (-2.3A)
ZN  A 501 (-2.5A)
None
None
 0.89A 1ekjA-2f4oA:
undetectable
1ekjB-2f4oA:
undetectable		 1ekjA-2f4oA:
21.86
1ekjB-2f4oA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 8 CYH A 283
CYH A 247
GLY A 251
GLY A 252
 ZN  A 501 (-2.3A)
ZN  A 501 (-2.5A)
None
None
 0.90A 1ekjG-2f4oA:
undetectable
1ekjH-2f4oA:
undetectable		 1ekjG-2f4oA:
21.86
1ekjH-2f4oA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 6 ARG A 302
ILE A 195
TRP A 233
PHE A 238
 None
 1.49A 1nsiC-2f4oA:
0.9
1nsiD-2f4oA:
undetectable		 1nsiC-2f4oA:
21.75
1nsiD-2f4oA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 2f4o XP-C REPAIR
COMPLEMENTING
COMPLEX 58 KDA
PROTEIN
(Mus
musculus) 		5 / 12 LEU B 314
LEU B 313
LEU B 302
MET B 288
LEU B 328
 None
 1.15A 1sqnB-2f4oB:
undetectable		 1sqnB-2f4oB:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		3 / 3 GLU A 337
THR A 336
LEU A 227
 None
 0.72A 1v8bC-2f4oA:
undetectable		 1v8bC-2f4oA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		3 / 3 ARG A 408
SER A 389
TYR A 388
 None
 0.70A 1x70A-2f4oA:
undetectable		 1x70A-2f4oA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		3 / 3 PHE A 289
ARG A 255
ASN A 277
 None
 0.88A 1xzxX-2f4oA:
undetectable		 1xzxX-2f4oA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		3 / 3 ASP A 332
ILE A 168
VAL A 395
 None
 0.66A 2avvD-2f4oA:
undetectable		 2avvD-2f4oA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		3 / 3 SER A 371
ASP A 332
CYH A 306
 None
 1.06A 2br4E-2f4oA:
undetectable		 2br4E-2f4oA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2f4o PEPTIDE N-GLYCANASE
XP-C REPAIR
COMPLEMENTING
COMPLEX 58 KDA
PROTEIN
(Mus
musculus;
Mus
musculus) 		5 / 12 ILE A 176
LEU A 172
GLY A 413
ASN A 412
GLN B 290
 None
 1.32A 2e7fB-2f4oA:
undetectable		 2e7fB-2f4oA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 6 ASP A 332
THR A 331
TYR A 330
TRP A 386
 None
 1.35A 2eimN-2f4oA:
undetectable
2eimP-2f4oA:
undetectable		 2eimN-2f4oA:
16.31
2eimP-2f4oA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		3 / 3 SER A 286
TYR A 279
HIS A 278
 None
 0.48A 2r2vD-2f4oA:
undetectable		 2r2vD-2f4oA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 5 ARG A 399
ASP A 383
ILE A 411
GLU A 404
 None
 1.27A 2xrzA-2f4oA:
undetectable
2xrzB-2f4oA:
undetectable		 2xrzA-2f4oA:
20.70
2xrzB-2f4oA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 7 ASP A 332
THR A 331
TYR A 330
TRP A 386
 None
 1.33A 3abkA-2f4oA:
undetectable
3abkC-2f4oA:
undetectable		 3abkA-2f4oA:
16.31
3abkC-2f4oA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 6 ASP A 332
THR A 331
TYR A 330
TRP A 386
 None
 1.32A 3ag1A-2f4oA:
undetectable
3ag1C-2f4oA:
undetectable		 3ag1A-2f4oA:
16.31
3ag1C-2f4oA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 6 ASP A 332
THR A 331
TYR A 330
TRP A 386
 None
 1.30A 3ag1N-2f4oA:
2.7
3ag1P-2f4oA:
undetectable		 3ag1N-2f4oA:
16.31
3ag1P-2f4oA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 7 ASP A 332
THR A 331
TYR A 330
TRP A 386
 None
 1.29A 3ag3A-2f4oA:
undetectable
3ag3C-2f4oA:
undetectable		 3ag3A-2f4oA:
16.31
3ag3C-2f4oA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 7 ASP A 332
THR A 331
TYR A 330
TRP A 386
 None
 1.31A 3ag3N-2f4oA:
undetectable
3ag3P-2f4oA:
undetectable		 3ag3N-2f4oA:
16.31
3ag3P-2f4oA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 7 TRP A 233
PHE A 238
ARG A 302
ILE A 195
 None
 1.46A 3ej8A-2f4oA:
0.0
3ej8B-2f4oA:
0.0		 3ej8A-2f4oA:
21.61
3ej8B-2f4oA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2f4o PEPTIDE N-GLYCANASE
XP-C REPAIR
COMPLEMENTING
COMPLEX 58 KDA
PROTEIN
(Mus
musculus) 		5 / 12 LEU B 313
LEU A 438
VAL A 439
LEU B 302
ILE B 292
 None
 1.11A 3gwxB-2f4oB:
undetectable		 3gwxB-2f4oB:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 5 LEU A 414
PHE A 376
ILE A 411
ILE A 374
 None
 1.04A 5dzk4-2f4oA:
undetectable
5dzkg-2f4oA:
2.1
5dzkm-2f4oA:
undetectable
5dzkn-2f4oA:
undetectable		 5dzk4-2f4oA:
1.01
5dzkg-2f4oA:
21.05
5dzkm-2f4oA:
21.26
5dzkn-2f4oA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 6 CYH A 356
LEU A 227
HIS A 232
LEU A 231
 None
 1.08A 5hpuC-2f4oA:
undetectable
5hpuD-2f4oA:
undetectable		 5hpuC-2f4oA:
11.45
5hpuD-2f4oA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		5 / 12 ALA A 319
PHE A 289
ILE A 245
PHE A 238
THR A 314
 None
 1.34A 5jlcA-2f4oA:
undetectable		 5jlcA-2f4oA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 2f4o XP-C REPAIR
COMPLEMENTING
COMPLEX 58 KDA
PROTEIN
(Mus
musculus) 		5 / 12 LEU B 313
LEU B 314
GLY B 307
LEU B 302
MET B 288
 None
 1.20A 5uc1A-2f4oB:
undetectable		 5uc1A-2f4oB:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 6 ASP A 332
THR A 331
TYR A 330
TRP A 386
 None
 1.29A 5x1bN-2f4oA:
undetectable
5x1bP-2f4oA:
undetectable		 5x1bN-2f4oA:
16.31
5x1bP-2f4oA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 7 ASP A 332
THR A 331
TYR A 330
TRP A 386
 None
 1.35A 5x1fN-2f4oA:
undetectable
5x1fP-2f4oA:
undetectable		 5x1fN-2f4oA:
16.31
5x1fP-2f4oA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		3 / 3 ARG A 325
PHE A 441
ARG A 387
 None
 1.10A 5y9yA-2f4oA:
undetectable		 5y9yA-2f4oA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2f4o PEPTIDE N-GLYCANASE
(Mus
musculus) 		4 / 6 ASP A 332
THR A 331
TYR A 330
TRP A 386
 None
 1.36A 6nmpA-2f4oA:
undetectable
6nmpC-2f4oA:
undetectable		 6nmpA-2f4oA:
16.31
6nmpC-2f4oA:
16.83