SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f4z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2f4z TGTWINSCAN_2721 - E2
DOMAIN
(Toxoplasma
gondii) 		4 / 8 MET A 111
LEU A  41
LEU A  37
LEU A 148
 None
 0.80A 1ereE-2f4zA:
undetectable		 1ereE-2f4zA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2f4z TGTWINSCAN_2721 - E2
DOMAIN
(Toxoplasma
gondii) 		4 / 8 MET A 111
LEU A  41
LEU A  37
LEU A 148
 None
 0.82A 1ereF-2f4zA:
undetectable		 1ereF-2f4zA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 2f4z TGTWINSCAN_2721 - E2
DOMAIN
(Toxoplasma
gondii) 		4 / 6 LEU A 148
MET A 154
MET A 111
LEU A 131
 None
 1.18A 1errB-2f4zA:
undetectable		 1errB-2f4zA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 2f4z TGTWINSCAN_2721 - E2
DOMAIN
(Toxoplasma
gondii) 		4 / 5 LEU A 148
ARG A 145
ALA A 147
ILE A  44
 None
 0.97A 2qhfA-2f4zA:
undetectable		 2qhfA-2f4zA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2f4z TGTWINSCAN_2721 - E2
DOMAIN
(Toxoplasma
gondii) 		4 / 7 PRO A 109
LEU A  37
ILE A  98
MET A 111
 None
 0.95A 3u5jA-2f4zA:
undetectable		 3u5jA-2f4zA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2f4z TGTWINSCAN_2721 - E2
DOMAIN
(Toxoplasma
gondii) 		4 / 8 PRO A 109
LEU A  37
ILE A  98
MET A 111
 None
 0.92A 3u5kC-2f4zA:
undetectable		 3u5kC-2f4zA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2f4z TGTWINSCAN_2721 - E2
DOMAIN
(Toxoplasma
gondii) 		4 / 8 PRO A 109
LEU A  37
ILE A  98
MET A 111
 None
 0.93A 3u5kD-2f4zA:
undetectable		 3u5kD-2f4zA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2f4z TGTWINSCAN_2721 - E2
DOMAIN
(Toxoplasma
gondii) 		5 / 12 ILE A  44
MET A 111
ILE A 100
PRO A 101
LEU A  37
 None
 1.00A 4gh8A-2f4zA:
undetectable		 4gh8A-2f4zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2f4z TGTWINSCAN_2721 - E2
DOMAIN
(Toxoplasma
gondii) 		5 / 10 LEU A 155
GLN A 152
VAL A  65
LEU A 148
MET A 111
 None
 1.37A 4r3aB-2f4zA:
undetectable		 4r3aB-2f4zA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2f4z TGTWINSCAN_2721 - E2
DOMAIN
(Toxoplasma
gondii) 		5 / 8 ILE A  69
VAL A  70
ILE A 151
ILE A 117
ILE A  81
 None
 1.33A 5hi2A-2f4zA:
undetectable		 5hi2A-2f4zA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2f4z TGTWINSCAN_2721 - E2
DOMAIN
(Toxoplasma
gondii) 		5 / 8 ILE A  69
VAL A  70
ILE A 151
ILE A 122
ILE A  81
 None
 1.40A 5hi2A-2f4zA:
undetectable		 5hi2A-2f4zA:
22.65