SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f57'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		4 / 5 SER A 571
THR A 532
GLU A 635
GLY A 639
 None
 0.87A 1icrA-2f57A:
undetectable
1icrB-2f57A:
undetectable		 1icrA-2f57A:
23.58
1icrB-2f57A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		4 / 5 GLU A 635
GLY A 639
SER A 571
THR A 532
 None
 0.86A 1icrA-2f57A:
undetectable
1icrB-2f57A:
undetectable		 1icrA-2f57A:
23.58
1icrB-2f57A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		4 / 6 SER A 571
THR A 532
GLU A 635
GLY A 639
 None
 0.89A 1icuA-2f57A:
undetectable
1icuB-2f57A:
undetectable		 1icuA-2f57A:
23.58
1icuB-2f57A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		4 / 6 GLU A 635
GLY A 639
SER A 571
THR A 532
 None
 0.90A 1icuA-2f57A:
undetectable
1icuB-2f57A:
undetectable		 1icuA-2f57A:
23.58
1icuB-2f57A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		4 / 6 SER A 571
THR A 532
GLU A 635
GLY A 639
 None
 0.90A 1icuC-2f57A:
undetectable
1icuD-2f57A:
undetectable		 1icuC-2f57A:
23.58
1icuD-2f57A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		4 / 5 SER A 571
THR A 532
GLU A 635
GLY A 639
 None
 0.88A 1icvC-2f57A:
undetectable
1icvD-2f57A:
undetectable		 1icvC-2f57A:
23.58
1icvD-2f57A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		4 / 5 GLU A 635
GLY A 639
SER A 571
THR A 532
 None
 0.92A 1icvC-2f57A:
undetectable
1icvD-2f57A:
undetectable		 1icvC-2f57A:
23.58
1icvD-2f57A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		4 / 6 SER A 571
THR A 532
GLU A 635
GLY A 639
 None
 0.87A 1kqbA-2f57A:
undetectable
1kqbB-2f57A:
undetectable		 1kqbA-2f57A:
22.78
1kqbB-2f57A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		4 / 5 GLU A 635
GLY A 639
SER A 571
THR A 532
 None
 0.89A 1kqbA-2f57A:
undetectable
1kqbB-2f57A:
undetectable		 1kqbA-2f57A:
22.78
1kqbB-2f57A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		4 / 6 SER A 571
THR A 532
GLU A 635
GLY A 639
 None
 0.85A 1kqbC-2f57A:
undetectable
1kqbD-2f57A:
undetectable		 1kqbC-2f57A:
22.78
1kqbD-2f57A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		4 / 6 GLU A 635
GLY A 639
SER A 571
THR A 532
 None
 0.86A 1kqbC-2f57A:
undetectable
1kqbD-2f57A:
undetectable		 1kqbC-2f57A:
22.78
1kqbD-2f57A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		3 / 3 PHE A 452
TRP A 520
GLU A 518
 None
 0.89A 1mogA-2f57A:
undetectable		 1mogA-2f57A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		3 / 3 ILE A 626
LEU A 629
VAL A 633
 None
 0.49A 1mz9B-2f57A:
undetectable		 1mz9B-2f57A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		6 / 12 VAL A 463
ALA A 476
MET A 498
VAL A 507
PHE A 525
ASP A 586
 None
None
None
None
None
TRS  A 802 (-2.6A)
 0.74A 1opjB-2f57A:
21.5		 1opjB-2f57A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		4 / 7 MET A 632
ILE A 569
ILE A 574
ASP A 572
 None
None
None
TRS  A 801 ( 4.9A)
 0.84A 1upfB-2f57A:
undetectable		 1upfB-2f57A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		5 / 12 ASN A 505
LEU A 584
ALA A 555
LEU A 629
LEU A 700
 None
 1.18A 2aa6B-2f57A:
undetectable		 2aa6B-2f57A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		5 / 12 ASN A 505
LEU A 584
ALA A 555
LEU A 629
LEU A 700
 None
 1.18A 2oaxD-2f57A:
undetectable		 2oaxD-2f57A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		5 / 12 ARG A 674
LEU A 679
GLU A 693
ALA A 689
ASP A 678
 None
 1.23A 3axtA-2f57A:
undetectable		 3axtA-2f57A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		5 / 10 ASP A 665
VAL A 663
VAL A 672
VAL A 633
ILE A 637
 None
 0.98A 3oxvB-2f57A:
undetectable		 3oxvB-2f57A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		5 / 12 VAL A 710
THR A 538
ILE A 574
VAL A 548
ILE A 545
 None
 1.37A 4eb6B-2f57A:
undetectable
4eb6C-2f57A:
undetectable		 4eb6B-2f57A:
21.40
4eb6C-2f57A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		6 / 10 ILE A 455
ALA A 476
VAL A 507
MET A 523
PHE A 525
LEU A 526
 None
 0.72A 4ks8A-2f57A:
40.9		 4ks8A-2f57A:
71.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		6 / 12 ILE A 455
GLY A 456
VAL A 463
ALA A 476
MET A 523
LEU A 526
 None
 0.68A 4qmzA-2f57A:
36.2		 4qmzA-2f57A:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		6 / 12 ILE A 455
VAL A 463
ALA A 476
MET A 523
LEU A 526
LEU A 575
 None
 0.73A 4qmzA-2f57A:
36.2		 4qmzA-2f57A:
35.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		4 / 5 LEU A 695
GLU A 693
MET A 680
LEU A 629
 None
 1.26A 4xi3B-2f57A:
undetectable		 4xi3B-2f57A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		5 / 8 LEU A 584
VAL A 506
ALA A 555
LEU A 556
CYH A 590
 None
 1.22A 4zauA-2f57A:
24.8		 4zauA-2f57A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		5 / 12 LEU A 550
ALA A 546
MET A 680
GLY A 675
LEU A 673
 None
 1.14A 5gtrA-2f57A:
undetectable		 5gtrA-2f57A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		5 / 12 PRO A 607
THR A 606
TRP A 609
THR A 532
SER A 573
 None
TRS  A 802 ( 4.9A)
None
None
TRS  A 802 ( 4.9A)
 1.16A 5xiqC-2f57A:
undetectable		 5xiqC-2f57A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		4 / 5 LEU A 436
VAL A 495
GLU A 494
LEU A 491
 None
 1.01A 5xooB-2f57A:
3.4		 5xooB-2f57A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens) 		5 / 9 ASN A 505
ILE A 626
PHE A 676
SER A 628
GLY A 630
 None
 1.39A 6awpA-2f57A:
undetectable		 6awpA-2f57A:
20.25