SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f58'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7W_A_MTXA301_1 (PTERIDINE REDUCTASE)	2f58	PROTEIN (IGG1 FAB 58.2 ANTIBODY (HEAVY CHAIN)) (Mus musculus)	5 / 12	ARG H 66 PRO H 41 LEU H 20 LEU H 18 ASP H 86	None	1.12A	1e7wA-2f58H: undetectable	1e7wA-2f58H: 25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y03_A_5FWA601_1 (BETA-1 ADRENERGIC RECEPTOR)	2f58	PROTEIN (IGG1 FAB 58.2 ANTIBODY (HEAVY CHAIN)) (Mus musculus)	5 / 12	VAL H 171 VAL H 191 SER H 189 ASN H 209 ASN H 162	None	1.44A	2y03A-2f58H: undetectable	2y03A-2f58H: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y03_B_5FWB601_1 (BETA-1 ADRENERGIC RECEPTOR)	2f58	PROTEIN (IGG1 FAB 58.2 ANTIBODY (HEAVY CHAIN)) (Mus musculus)	5 / 12	VAL H 171 VAL H 191 SER H 189 ASN H 209 ASN H 162	None	1.49A	2y03B-2f58H: undetectable	2y03B-2f58H: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIW_D_LOCD503_1 (TUBULIN ALPHA-1B CHAIN TUBULIN BETA CHAIN)	2f58	PROTEIN (IGG1 FAB 58.2 ANTIBODY (HEAVY CHAIN)) (Mus musculus)	3 / 3	SER H 216 ALA H 211 VAL H 210	None	0.54A	5xiwC-2f58H: undetectable	5xiwC-2f58H: 16.35

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E7W_A_MTXA301_1","PTERIDINE REDUCTASE","2f58","PROTEIN (IGG1 FAB 58.2 ANTIBODY (HEAVY CHAIN))","Mus musculus",5,"ARG H  66;PRO H  41;LEU H  20;LEU H  18;ASP H  86","None","1.12A","1e7wA-2f58H:undetectable","1e7wA-2f58H:25.56"],["2Y03_A_5FWA601_1","BETA-1 ADRENERGIC RECEPTOR","2f58","PROTEIN (IGG1 FAB 58.2 ANTIBODY (HEAVY CHAIN))","Mus musculus",5,"VAL H 171;VAL H 191;SER H 189;ASN H 209;ASN H 162","None","1.44A","2y03A-2f58H:undetectable","2y03A-2f58H:19.44"],["2Y03_B_5FWB601_1","BETA-1 ADRENERGIC RECEPTOR","2f58","PROTEIN (IGG1 FAB 58.2 ANTIBODY (HEAVY CHAIN))","Mus musculus",5,"VAL H 171;VAL H 191;SER H 189;ASN H 209;ASN H 162","None","1.49A","2y03B-2f58H:undetectable","2y03B-2f58H:19.44"],["5XIW_D_LOCD503_1","TUBULIN ALPHA-1B CHAIN;TUBULIN BETA CHAIN","2f58","PROTEIN (IGG1 FAB 58.2 ANTIBODY (HEAVY CHAIN))","Mus musculus",3,"SER H 216;ALA H 211;VAL H 210","None","0.54A","5xiwC-2f58H:undetectable","5xiwC-2f58H:16.35"]]