SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2f59 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Brucella
abortus) 		5 / 10 GLU A  40
ALA A  37
ALA A 142
PHE A 140
GLY A 114
 None
 1.17A 1mjqG-2f59A:
undetectable
1mjqH-2f59A:
undetectable		 1mjqG-2f59A:
19.75
1mjqH-2f59A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2f59 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1
(Brucella
abortus) 		5 / 12 GLU A 123
LEU A  30
ALA A  20
PHE A  91
ILE A 117
 None
None
INI  A 201 ( 3.7A)
INI  A 201 (-4.0A)
None
 1.29A 4xe5A-2f59A:
undetectable		 4xe5A-2f59A:
10.07