SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 2f5a PROTEIN (ANTIBODY
2F5 (HEAVY CHAIN))
(Homo
sapiens) 		5 / 12 ARG H  68
PRO H  43
LEU H  20
LEU H  18
ASP H  91
 None
 1.31A 1e7wA-2f5aH:
undetectable		 1e7wA-2f5aH:
24.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 2f5a PROTEIN (ANTIBODY
2F5 (HEAVY CHAIN))
PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))
(Homo
sapiens) 		6 / 12 TYR L  36
GLN L  89
TYR L  94
PHE L  98
ALA H  98
TRP H 122
 None
 0.65A 1h8sA-2f5aL:
22.5		 1h8sA-2f5aL:
39.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2f5a PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))
(Homo
sapiens) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.82A 2aojA-2f5aL:
undetectable		 2aojA-2f5aL:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2f5a PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))
(Homo
sapiens) 		4 / 7 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.70A 2aojB-2f5aL:
undetectable		 2aojB-2f5aL:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2f5a PROTEIN (ANTIBODY
2F5 (HEAVY CHAIN))
(Homo
sapiens) 		5 / 12 VAL H  34
SER H  30
SER H  55
PHE H  24
ASN H  78
 None
 1.37A 2y00A-2f5aH:
undetectable		 2y00A-2f5aH:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2f5a PROTEIN (ANTIBODY
2F5 (HEAVY CHAIN))
(Homo
sapiens) 		5 / 12 VAL H  12
ILE H 130
LEU H  65
ARG H  68
TYR H  95
 None
 1.44A 3apwB-2f5aH:
undetectable		 3apwB-2f5aH:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2f5a PROTEIN (ANTIBODY
2F5 (HEAVY CHAIN))
(Homo
sapiens) 		4 / 6 LEU H 208
GLY H 209
ALA H 144
PRO H 145
 None
 0.47A 3huoA-2f5aH:
undetectable		 3huoA-2f5aH:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 2f5a PROTEIN (ANTIBODY
2F5 (HEAVY CHAIN))
PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))
(Homo
sapiens) 		4 / 6 PRO L  95
GLY L  99
ALA L   1
GLN H  41
 None
 1.05A 4g0uA-2f5aL:
2.9		 4g0uA-2f5aL:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 2f5a PROTEIN (ANTIBODY
2F5 (HEAVY CHAIN))
PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))
(Homo
sapiens) 		3 / 3 LEU H  47
MET H 119
TYR L  86
 None
 0.95A 4p6xG-2f5aH:
undetectable		 4p6xG-2f5aH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 2f5a PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))
(Homo
sapiens) 		4 / 7 ASP L 170
THR L 172
TYR L 140
THR L 109
 None
 1.28A 5b6iA-2f5aL:
undetectable		 5b6iA-2f5aL:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 2f5a PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))
(Homo
sapiens) 		4 / 6 ASP L 170
THR L 172
TYR L 140
THR L 109
 None
 1.27A 5b6iB-2f5aL:
undetectable		 5b6iB-2f5aL:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 2f5a PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))
(Homo
sapiens) 		4 / 7 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.84A 5bojB-2f5aL:
undetectable		 5bojB-2f5aL:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2f5a PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))
(Homo
sapiens) 		3 / 3 THR L 102
THR L  85
PHE L  83
 None
 0.87A 5cxvA-2f5aL:
undetectable		 5cxvA-2f5aL:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 2f5a PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))
(Homo
sapiens) 		4 / 8 THR L  74
SER L  63
THR L  72
SER L  65
 None
 1.03A 5l4eA-2f5aL:
undetectable
5l4eB-2f5aL:
undetectable
5l4eC-2f5aL:
undetectable
5l4eD-2f5aL:
undetectable
5l4eE-2f5aL:
3.1		 5l4eA-2f5aL:
22.77
5l4eB-2f5aL:
22.77
5l4eC-2f5aL:
22.77
5l4eD-2f5aL:
22.77
5l4eE-2f5aL:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 2f5a PROTEIN (ANTIBODY
2F5 (HEAVY CHAIN))
PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))
(Homo
sapiens) 		4 / 4 PHE H 141
LEU L 181
LEU L 125
VAL L 132
 None
 1.37A 5xxiA-2f5aH:
undetectable		 5xxiA-2f5aH:
18.68