SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB
(Thermococcus
litoralis) 		4 / 6 PHE X 144
ILE X 165
VAL X 182
PHE X 180
 None
 0.97A 2cizA-2f5tX:
undetectable		 2cizA-2f5tX:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB
(Thermococcus
litoralis) 		3 / 3 GLY X 338
ARG X 270
TYR X 273
 None
 0.86A 2opxA-2f5tX:
undetectable		 2opxA-2f5tX:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB
(Thermococcus
litoralis) 		5 / 12 PHE X 216
GLY X 193
ASP X 150
ILE X 147
LEU X 191
 None
 1.26A 3iv6A-2f5tX:
undetectable		 3iv6A-2f5tX:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB
(Thermococcus
litoralis) 		5 / 12 PHE X 216
GLY X 193
ILE X 147
THR X 146
LEU X 191
 None
 1.11A 3iv6A-2f5tX:
undetectable		 3iv6A-2f5tX:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB
(Thermococcus
litoralis) 		5 / 12 PHE X 216
GLY X 193
ASP X 150
ILE X 147
LEU X 191
 None
 1.20A 3iv6C-2f5tX:
2.6		 3iv6C-2f5tX:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB
(Thermococcus
litoralis) 		5 / 12 PHE X 216
SER X 127
ASP X 150
ILE X 147
LEU X 191
 None
 1.26A 3iv6C-2f5tX:
2.6		 3iv6C-2f5tX:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB
(Thermococcus
litoralis) 		4 / 5 ARG X 341
ARG X 292
GLY X 291
GLU X 310
 None
 1.29A 3k9fA-2f5tX:
undetectable
3k9fB-2f5tX:
undetectable
3k9fC-2f5tX:
undetectable		 3k9fA-2f5tX:
18.20
3k9fB-2f5tX:
18.20
3k9fC-2f5tX:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB
(Thermococcus
litoralis) 		5 / 9 PHE X 124
SER X 127
THR X 154
VAL X 161
VAL X 137
 None
 1.36A 4wnvA-2f5tX:
undetectable		 4wnvA-2f5tX:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB
(Thermococcus
litoralis) 		5 / 9 PHE X 124
SER X 127
THR X 154
VAL X 161
VAL X 137
 None
 1.39A 4wnvB-2f5tX:
0.0		 4wnvB-2f5tX:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB
(Thermococcus
litoralis) 		4 / 5 VAL X 161
THR X 154
ASP X 150
LEU X 128
 None
 1.24A 5m0iB-2f5tX:
undetectable		 5m0iB-2f5tX:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB
(Thermococcus
litoralis) 		4 / 5 LEU X 309
LEU X 289
MET X 256
TYR X 296
 None
 1.46A 5uc3A-2f5tX:
undetectable		 5uc3A-2f5tX:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB
(Thermococcus
litoralis) 		4 / 6 ILE X 336
GLY X 291
TYR X 273
GLU X 275
 None
 1.11A 6gqiA-2f5tX:
undetectable		 6gqiA-2f5tX:
18.98