SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 2f5x BUGD
(Bordetella
pertussis) 		3 / 3 ALA A 279
VAL A 281
TRP A 230
 None
 0.99A 1gmkC-2f5xA:
undetectable
1gmkD-2f5xA:
undetectable		 1gmkC-2f5xA:
6.80
1gmkD-2f5xA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2f5x BUGD
(Bordetella
pertussis) 		5 / 9 THR A  52
GLY A  48
GLY A 228
PHE A  72
LEU A  66
 None
 1.21A 1l4nA-2f5xA:
undetectable		 1l4nA-2f5xA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 2f5x BUGD
(Bordetella
pertussis) 		4 / 7 ASN A 132
GLY A  45
PRO A 164
ALA A 165
 None
 0.79A 1n49A-2f5xA:
undetectable		 1n49A-2f5xA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2f5x BUGD
(Bordetella
pertussis) 		5 / 11 GLY A 224
VAL A 223
GLU A 222
ASP A  98
ILE A 225
 None
 1.19A 1pk9C-2f5xA:
undetectable		 1pk9C-2f5xA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2f5x BUGD
(Bordetella
pertussis) 		5 / 8 ALA A 138
GLY A  48
GLY A  47
ILE A 135
ALA A 131
 ASP  A 901 (-3.5A)
None
None
None
None
 1.10A 1sguA-2f5xA:
undetectable		 1sguA-2f5xA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2f5x BUGD
(Bordetella
pertussis) 		4 / 7 VAL A  40
LEU A  26
HIS A 227
THR A  19
 None
None
None
ASP  A 901 (-3.8A)
 1.15A 2f78A-2f5xA:
7.2		 2f78A-2f5xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2f5x BUGD
(Bordetella
pertussis) 		4 / 7 TYR A  79
GLY A 134
ASN A 132
ASP A 168
 None
 1.10A 2g72B-2f5xA:
undetectable		 2g72B-2f5xA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2f5x BUGD
(Bordetella
pertussis) 		6 / 12 GLY A 136
LEU A 146
GLY A 143
ASN A 132
LEU A 130
LEU A 154
 None
 1.31A 2nxeA-2f5xA:
undetectable		 2nxeA-2f5xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 2f5x BUGD
(Bordetella
pertussis) 		4 / 8 VAL A  11
PRO A  12
THR A  52
VAL A  55
 None
 0.98A 2v32C-2f5xA:
undetectable
2v32D-2f5xA:
undetectable		 2v32C-2f5xA:
21.05
2v32D-2f5xA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2f5x BUGD
(Bordetella
pertussis) 		4 / 7 MET A 229
ALA A  23
ALA A  27
LEU A  34
 None
 0.94A 2wx2A-2f5xA:
undetectable		 2wx2A-2f5xA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2f5x BUGD
(Bordetella
pertussis) 		4 / 8 MET A 229
ALA A  23
ALA A  27
LEU A  34
 None
 0.82A 2wx2B-2f5xA:
undetectable		 2wx2B-2f5xA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2f5x BUGD
(Bordetella
pertussis) 		5 / 12 LEU A 268
ASP A  98
GLY A 224
GLN A 287
ILE A 225
 None
 1.20A 2ycjA-2f5xA:
undetectable		 2ycjA-2f5xA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2f5x BUGD
(Bordetella
pertussis) 		3 / 3 SER A 139
GLY A 134
GLY A 161
 ASP  A 901 (-2.7A)
None
ASP  A 901 (-3.2A)
 0.52A 3bogA-2f5xA:
undetectable
3bogC-2f5xA:
undetectable		 3bogA-2f5xA:
undetectable
3bogC-2f5xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 2f5x BUGD
(Bordetella
pertussis) 		3 / 3 TYR A 159
ASP A 175
ASP A 168
 None
 0.83A 3r24A-2f5xA:
undetectable		 3r24A-2f5xA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2f5x BUGD
(Bordetella
pertussis) 		5 / 11 GLY A 224
VAL A 223
GLU A 222
ASP A  98
ILE A 225
 None
 1.22A 3uawA-2f5xA:
undetectable		 3uawA-2f5xA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 2f5x BUGD
(Bordetella
pertussis) 		4 / 8 SER A 216
ILE A 114
LEU A 146
ILE A 103
 None
 0.94A 4dtaB-2f5xA:
undetectable		 4dtaB-2f5xA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 2f5x BUGD
(Bordetella
pertussis) 		4 / 6 ARG A 106
ALA A 105
ASP A 108
LEU A 117
 None
 1.08A 4ot2A-2f5xA:
undetectable		 4ot2A-2f5xA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2f5x BUGD
(Bordetella
pertussis) 		5 / 12 LEU A 207
GLN A 186
GLN A 187
ALA A 195
MET A 166
 None
 1.10A 4rp8C-2f5xA:
undetectable		 4rp8C-2f5xA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 2f5x BUGD
(Bordetella
pertussis) 		5 / 12 HIS A  69
ALA A 138
SER A 139
GLY A  17
GLY A  44
 ASP  A 901 (-3.9A)
ASP  A 901 (-3.5A)
ASP  A 901 (-2.7A)
ASP  A 901 ( 4.5A)
None
 1.23A 4uilH-2f5xA:
undetectable
4uilL-2f5xA:
undetectable		 4uilH-2f5xA:
22.54
4uilL-2f5xA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2f5x BUGD
(Bordetella
pertussis) 		4 / 6 SER A 190
ASP A 108
ARG A 106
GLY A 171
 None
 1.00A 5cdqA-2f5xA:
undetectable
5cdqC-2f5xA:
undetectable
5cdqD-2f5xA:
undetectable		 5cdqA-2f5xA:
20.42
5cdqC-2f5xA:
20.42
5cdqD-2f5xA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2f5x BUGD
(Bordetella
pertussis) 		5 / 12 ARG A 259
LEU A 263
VAL A  99
HIS A 227
GLY A  16
 None
 1.39A 5i8fA-2f5xA:
undetectable		 5i8fA-2f5xA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 2f5x BUGD
(Bordetella
pertussis) 		5 / 9 VAL A 193
GLY A 107
ILE A 157
LEU A 130
ASP A 179
 None
 1.47A 6c2mC-2f5xA:
undetectable		 6c2mC-2f5xA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2f5x BUGD
(Bordetella
pertussis) 		5 / 9 LEU A  26
GLY A  94
LEU A 247
GLN A 248
VAL A  97
 None
 1.28A 6czmA-2f5xA:
6.0
6czmB-2f5xA:
3.6		 6czmA-2f5xA:
23.22
6czmB-2f5xA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2f5x BUGD
(Bordetella
pertussis) 		5 / 10 LEU A  26
GLY A  94
LEU A 247
GLN A 248
VAL A  97
 None
 1.17A 6czmE-2f5xA:
0.0
6czmF-2f5xA:
4.4		 6czmE-2f5xA:
23.22
6czmF-2f5xA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2f5x BUGD
(Bordetella
pertussis) 		5 / 12 GLY A  94
PHE A  13
GLY A  47
THR A  49
MET A  68
 None
ASP  A 901 (-3.4A)
None
None
None
 1.22A 6e8qA-2f5xA:
undetectable		 6e8qA-2f5xA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 2f5x BUGD
(Bordetella
pertussis) 		4 / 7 GLN A 287
GLY A 136
SER A  73
GLY A  71
 None
 0.72A 6ekzA-2f5xA:
undetectable		 6ekzA-2f5xA:
15.93