SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f6d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AGM_A_ACRA495_1
(GLUCOAMYLASE-471)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		12 / 12 ALA A  54
TYR A  63
TRP A  67
ARG A  69
ASP A  70
TRP A 139
GLY A 140
GLU A 211
ARG A 345
TYR A 351
TRP A 362
GLU A 456
 ACR  A 995 (-3.4A)
ACR  A 995 (-4.3A)
ACR  A 995 (-3.4A)
ACR  A 995 (-3.7A)
ACR  A 995 (-3.0A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.3A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.0A)
ACR  A 995 ( 3.7A)
None
ACR  A 995 ( 4.6A)
 0.21A 1agmA-2f6dA:
45.9		 1agmA-2f6dA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AGM_A_ACRA495_2
(GLUCOAMYLASE-471)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 4 TRP A 209
GLU A 210
LEU A 471
TRP A 473
 None
ACR  A 995 (-3.7A)
None
None
 0.16A 1agmA-2f6dA:
45.9		 1agmA-2f6dA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AGM_A_ACRA496_1
(GLUCOAMYLASE-471)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		12 / 12 ALA A  54
TYR A  63
TRP A  67
ARG A  69
ASP A  70
TRP A 139
GLY A 140
GLU A 211
ARG A 345
TYR A 351
TRP A 362
GLU A 456
 ACR  A 995 (-3.4A)
ACR  A 995 (-4.3A)
ACR  A 995 (-3.4A)
ACR  A 995 (-3.7A)
ACR  A 995 (-3.0A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.3A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.0A)
ACR  A 995 ( 3.7A)
None
ACR  A 995 ( 4.6A)
 0.21A 1agmA-2f6dA:
45.9		 1agmA-2f6dA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AGM_A_ACRA496_2
(GLUCOAMYLASE-471)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 5 TRP A 209
GLU A 210
LEU A 471
TRP A 473
 None
ACR  A 995 (-3.7A)
None
None
 0.16A 1agmA-2f6dA:
45.9		 1agmA-2f6dA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GAH_A_ACRA497_1
(GLUCOAMYLASE-471)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		11 / 12 TYR A  63
TRP A  67
ARG A  69
ASP A  70
TRP A 139
GLY A 140
GLU A 210
GLU A 211
TYR A 351
TRP A 362
GLU A 456
 ACR  A 995 (-4.3A)
ACR  A 995 (-3.4A)
ACR  A 995 (-3.7A)
ACR  A 995 (-3.0A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.3A)
ACR  A 995 (-3.7A)
ACR  A 995 (-3.5A)
ACR  A 995 ( 3.7A)
None
ACR  A 995 ( 4.6A)
 0.15A 1gahA-2f6dA:
45.7		 1gahA-2f6dA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 6 ALA A  54
TRP A 209
ARG A 345
LEU A 471
TRP A 473
 ACR  A 995 (-3.4A)
None
ACR  A 995 (-3.0A)
None
None
 0.18A 1gahA-2f6dA:
45.7		 1gahA-2f6dA:
34.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_C_BEZC1162_0
(PEROXIREDOXIN 5)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 9 PRO A 126
THR A  68
GLY A 146
PHE A 128
GLY A 122
 None
 1.35A 1h4oC-2f6dA:
undetectable
1h4oD-2f6dA:
undetectable		 1h4oC-2f6dA:
16.02
1h4oD-2f6dA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 9 PRO A 126
THR A  68
GLY A 146
PHE A 128
GLY A 122
 None
 1.35A 1h4oE-2f6dA:
undetectable
1h4oF-2f6dA:
undetectable		 1h4oE-2f6dA:
16.02
1h4oF-2f6dA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 6 TYR A 229
VAL A  95
ILE A  99
LEU A 194
 None
 1.17A 1j96A-2f6dA:
undetectable		 1j96A-2f6dA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 6 ARG A 345
GLY A 359
ASP A 349
TYR A 331
 ACR  A 995 (-3.0A)
None
None
None
 1.25A 1kf6M-2f6dA:
undetectable
1kf6N-2f6dA:
undetectable		 1kf6M-2f6dA:
21.27
1kf6N-2f6dA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_A_ACRA700_1
(GLUCOAMYLASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		9 / 12 ALA A  54
TYR A  63
TRP A  67
ARG A  69
ASP A  70
GLU A 211
ARG A 345
TYR A 351
TRP A 473
 ACR  A 995 (-3.4A)
ACR  A 995 (-4.3A)
ACR  A 995 (-3.4A)
ACR  A 995 (-3.7A)
ACR  A 995 (-3.0A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.0A)
ACR  A 995 ( 3.7A)
None
 0.32A 1lf9A-2f6dA:
29.6		 1lf9A-2f6dA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_A_ACRA700_1
(GLUCOAMYLASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 12 ALA A  54
TYR A  63
TRP A 139
GLU A 211
TYR A 351
 ACR  A 995 (-3.4A)
ACR  A 995 (-4.3A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.5A)
ACR  A 995 ( 3.7A)
 0.93A 1lf9A-2f6dA:
29.6		 1lf9A-2f6dA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_A_ACRA700_2
(GLUCOAMYLASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 4 TRP A 209
GLU A 210
TRP A 362
LEU A 471
 None
ACR  A 995 (-3.7A)
None
None
 0.36A 1lf9A-2f6dA:
29.6		 1lf9A-2f6dA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_B_ACRB701_1
(GLUCOAMYLASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		9 / 12 ALA A  54
TYR A  63
TRP A  67
ARG A  69
ASP A  70
GLU A 211
ARG A 345
TYR A 351
TRP A 362
 ACR  A 995 (-3.4A)
ACR  A 995 (-4.3A)
ACR  A 995 (-3.4A)
ACR  A 995 (-3.7A)
ACR  A 995 (-3.0A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.0A)
ACR  A 995 ( 3.7A)
None
 0.42A 1lf9B-2f6dA:
29.5		 1lf9B-2f6dA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_B_ACRB701_1
(GLUCOAMYLASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 12 ALA A  54
TYR A  63
TRP A 139
GLU A 211
TYR A 351
 ACR  A 995 (-3.4A)
ACR  A 995 (-4.3A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.5A)
ACR  A 995 ( 3.7A)
 0.91A 1lf9B-2f6dA:
29.5		 1lf9B-2f6dA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_B_ACRB701_2
(GLUCOAMYLASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 4 TRP A 209
GLU A 210
LEU A 471
TRP A 473
 None
ACR  A 995 (-3.7A)
None
None
 0.47A 1lf9B-2f6dA:
29.5		 1lf9B-2f6dA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 12 SER A 470
TYR A 469
PHE A   5
PHE A  21
VAL A  28
 None
 1.27A 1q23C-2f6dA:
undetectable		 1q23C-2f6dA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 12 SER A 470
TYR A 469
PHE A   5
SER A  29
PHE A  21
 None
 1.38A 1q23C-2f6dA:
undetectable		 1q23C-2f6dA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 12 SER A 470
TYR A 469
PHE A   5
SER A  29
PHE A  21
 None
 1.43A 1q23D-2f6dA:
undetectable
1q23E-2f6dA:
undetectable		 1q23D-2f6dA:
18.29
1q23E-2f6dA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 11 SER A 470
TYR A 469
PHE A   5
SER A  29
PHE A  21
 None
 1.38A 1q23G-2f6dA:
0.0		 1q23G-2f6dA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 11 SER A 470
TYR A 469
PHE A   5
PHE A  21
VAL A  28
 None
 1.29A 1q23I-2f6dA:
undetectable		 1q23I-2f6dA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 11 SER A 470
TYR A 469
PHE A   5
SER A  29
PHE A  21
 None
 1.41A 1q23I-2f6dA:
undetectable		 1q23I-2f6dA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 11 SER A 470
TYR A 469
PHE A   5
PHE A  21
VAL A  28
 None
 1.30A 1q23L-2f6dA:
undetectable		 1q23L-2f6dA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_1
(GLUCODEXTRANASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		9 / 12 ALA A  54
TYR A  63
TRP A  67
ARG A  69
ASP A  70
GLU A 211
ARG A 345
TYR A 351
TRP A 362
 ACR  A 995 (-3.4A)
ACR  A 995 (-4.3A)
ACR  A 995 (-3.4A)
ACR  A 995 (-3.7A)
ACR  A 995 (-3.0A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.0A)
ACR  A 995 ( 3.7A)
None
 0.49A 1ulvA-2f6dA:
31.1		 1ulvA-2f6dA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_2
(GLUCODEXTRANASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 5 GLN A 143
GLU A 210
LEU A 364
TRP A 362
 None
ACR  A 995 (-3.7A)
None
None
 1.44A 1ulvA-2f6dA:
31.1		 1ulvA-2f6dA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_2
(GLUCODEXTRANASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 5 TRP A 209
GLU A 210
LEU A 471
TRP A 473
 None
ACR  A 995 (-3.7A)
None
None
 0.38A 1ulvA-2f6dA:
31.1		 1ulvA-2f6dA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		3 / 3 ASP A 312
ILE A 301
VAL A 434
 NA  A 997 ( 4.9A)
PO4  A 900 (-4.6A)
None
 0.66A 2avvD-2f6dA:
undetectable		 2avvD-2f6dA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 10 PRO A 126
THR A  68
GLY A 146
PHE A 128
GLY A 122
 None
 1.35A 2vl2A-2f6dA:
undetectable
2vl2C-2f6dA:
undetectable		 2vl2A-2f6dA:
16.49
2vl2C-2f6dA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		3 / 3 PRO A 147
GLY A 124
TYR A 196
 None
 0.68A 2vouB-2f6dA:
undetectable		 2vouB-2f6dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		3 / 3 PRO A 147
GLY A 124
TYR A 196
 None
 0.70A 2vouC-2f6dA:
undetectable		 2vouC-2f6dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		3 / 3 SER A 102
ARG A 107
GLN A 106
 None
 0.90A 2xnrA-2f6dA:
undetectable		 2xnrA-2f6dA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 10 PHE A 217
GLY A 286
ASN A 266
VAL A 316
PHE A 309
 None
 1.16A 3ay0B-2f6dA:
undetectable		 3ay0B-2f6dA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 7 LEU A 208
ASP A 288
ARG A 345
ALA A 290
 None
None
ACR  A 995 (-3.0A)
None
 1.14A 3mbgA-2f6dA:
undetectable
3mbgB-2f6dA:
undetectable		 3mbgA-2f6dA:
12.60
3mbgB-2f6dA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		3 / 3 ASP A 288
ARG A 345
ALA A 290
 None
ACR  A 995 (-3.0A)
None
 0.80A 3mbgC-2f6dA:
undetectable		 3mbgC-2f6dA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 6 ARG A  69
GLN A 143
PRO A 147
LEU A 149
 ACR  A 995 (-3.7A)
None
None
None
 1.24A 3tgvD-2f6dA:
undetectable		 3tgvD-2f6dA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 8 ASN A 408
ILE A 407
ASN A 398
ASP A 403
 None
 1.06A 4d33A-2f6dA:
undetectable		 4d33A-2f6dA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 7 ASN A 408
ILE A 407
ASN A 398
ASP A 403
 None
 1.09A 4d33B-2f6dA:
undetectable		 4d33B-2f6dA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 8 ASN A 408
ILE A 407
ASN A 398
ASP A 403
 None
 1.10A 4d39A-2f6dA:
undetectable		 4d39A-2f6dA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 8 ASP A 379
ASP A 312
VAL A 316
LEU A 296
 PO4  A 900 (-3.1A)
NA  A 997 ( 4.9A)
None
None
 0.72A 4f8hA-2f6dA:
undetectable
4f8hB-2f6dA:
undetectable		 4f8hA-2f6dA:
20.99
4f8hB-2f6dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 8 ASP A 379
ASP A 312
VAL A 316
LEU A 296
 PO4  A 900 (-3.1A)
NA  A 997 ( 4.9A)
None
None
 0.71A 4f8hB-2f6dA:
undetectable
4f8hC-2f6dA:
undetectable		 4f8hB-2f6dA:
20.99
4f8hC-2f6dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 8 ASP A 379
ASP A 312
VAL A 316
LEU A 296
 PO4  A 900 (-3.1A)
NA  A 997 ( 4.9A)
None
None
 0.71A 4f8hC-2f6dA:
undetectable
4f8hD-2f6dA:
undetectable		 4f8hC-2f6dA:
20.99
4f8hD-2f6dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 8 ASP A 379
ASP A 312
VAL A 316
LEU A 296
 PO4  A 900 (-3.1A)
NA  A 997 ( 4.9A)
None
None
 0.71A 4f8hD-2f6dA:
undetectable
4f8hE-2f6dA:
undetectable		 4f8hD-2f6dA:
20.99
4f8hE-2f6dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 8 VAL A 316
LEU A 296
ASP A 379
ASP A 312
 None
None
PO4  A 900 (-3.1A)
NA  A 997 ( 4.9A)
 0.70A 4f8hA-2f6dA:
undetectable
4f8hE-2f6dA:
undetectable		 4f8hA-2f6dA:
20.99
4f8hE-2f6dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 8 ASP A 349
ASP A 207
GLU A 456
ASP A 288
 None
None
ACR  A 995 ( 4.6A)
None
 0.99A 4feuD-2f6dA:
undetectable		 4feuD-2f6dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 7 ASP A 349
ASP A 207
GLU A 456
ASP A 288
 None
None
ACR  A 995 ( 4.6A)
None
 1.04A 4fevB-2f6dA:
undetectable		 4fevB-2f6dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 7 ASP A 349
ASP A 207
GLU A 456
ASP A 288
 None
None
ACR  A 995 ( 4.6A)
None
 1.06A 4fewB-2f6dA:
undetectable		 4fewB-2f6dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		3 / 3 ASP A 160
ARG A 156
ASP A  84
 None
 0.69A 4fp9D-2f6dA:
undetectable		 4fp9D-2f6dA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		3 / 3 ASP A 160
ARG A 156
ASP A  84
 None
 0.81A 4fzvA-2f6dA:
undetectable		 4fzvA-2f6dA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 8 ASP A 349
ASP A 207
GLU A 456
ASP A 288
 None
None
ACR  A 995 ( 4.6A)
None
 1.05A 4gkhD-2f6dA:
undetectable		 4gkhD-2f6dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 12 LEU A 246
SER A 155
LEU A 158
PHE A 237
ASP A 238
 None
 1.49A 4j7xJ-2f6dA:
undetectable		 4j7xJ-2f6dA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 5 LEU A 433
PRO A 373
LEU A 376
ILE A 387
 None
 1.08A 4klrA-2f6dA:
undetectable		 4klrA-2f6dA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 8 PHE A   5
THR A 472
SER A 470
ASP A  70
 None
None
None
ACR  A 995 (-3.0A)
 1.39A 4qb9D-2f6dA:
undetectable		 4qb9D-2f6dA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 5 LYS A 399
LEU A 324
GLU A 325
TYR A 321
 None
 1.50A 4z4hA-2f6dA:
0.0		 4z4hA-2f6dA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		3 / 3 ASP A 310
GLU A 254
SER A 382
 NA  A 997 (-3.2A)
None
PO4  A 900 ( 4.9A)
 0.83A 5bw4B-2f6dA:
undetectable		 5bw4B-2f6dA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 6 THR A  77
GLY A 476
GLU A 480
ILE A 444
 None
 0.90A 5kmfA-2f6dA:
undetectable
5kmfC-2f6dA:
undetectable		 5kmfA-2f6dA:
21.21
5kmfC-2f6dA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 6 PHE A 128
THR A  68
ARG A 150
GLY A  50
 None
 1.23A 5mraA-2f6dA:
undetectable
5mraB-2f6dA:
undetectable		 5mraA-2f6dA:
15.68
5mraB-2f6dA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 12 GLY A 132
PRO A  49
GLY A  50
ASN A 129
ASP A 131
 None
 1.18A 5yniA-2f6dA:
undetectable		 5yniA-2f6dA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		5 / 12 GLY A 132
PRO A  49
GLY A  50
ASN A 129
ASP A 131
 None
 1.17A 5ynmA-2f6dA:
undetectable		 5ynmA-2f6dA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		3 / 3 ASP A 160
ARG A 156
ASP A  84
 None
 0.74A 5zvgA-2f6dA:
undetectable		 5zvgA-2f6dA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		3 / 3 ASP A 160
ARG A 156
ASP A  84
 None
 0.69A 5zvgB-2f6dA:
undetectable		 5zvgB-2f6dA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		3 / 3 ASN A 455
VAL A 443
HIS A 447
 None
None
ACR  A 996 (-3.4A)
 0.87A 6a5yD-2f6dA:
undetectable		 6a5yD-2f6dA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_1
(GLUCOAMYLASE P)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		12 / 12 ALA A  54
TYR A  63
TRP A  67
ARG A  69
ASP A  70
TRP A 139
GLY A 140
GLU A 211
ARG A 345
TYR A 351
TRP A 362
TRP A 473
 ACR  A 995 (-3.4A)
ACR  A 995 (-4.3A)
ACR  A 995 (-3.4A)
ACR  A 995 (-3.7A)
ACR  A 995 (-3.0A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.3A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.0A)
ACR  A 995 ( 3.7A)
None
None
 0.36A 6fhwA-2f6dA:
45.3		 6fhwA-2f6dA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		3 / 3 TRP A 209
GLU A 210
GLU A 456
 None
ACR  A 995 (-3.7A)
ACR  A 995 ( 4.6A)
 0.19A 6fhwA-2f6dA:
45.3		 6fhwA-2f6dA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		3 / 3 TRP A 473
GLU A 456
GLU A 210
 None
ACR  A 995 ( 4.6A)
ACR  A 995 (-3.7A)
 0.86A 6fhwA-2f6dA:
45.3		 6fhwA-2f6dA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_B_ACRB801_1
(GLUCOAMYLASE P)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		12 / 12 ALA A  54
TYR A  63
TRP A  67
ARG A  69
ASP A  70
TRP A 139
GLY A 140
GLU A 211
ARG A 345
TYR A 351
TRP A 362
TRP A 473
 ACR  A 995 (-3.4A)
ACR  A 995 (-4.3A)
ACR  A 995 (-3.4A)
ACR  A 995 (-3.7A)
ACR  A 995 (-3.0A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.3A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.0A)
ACR  A 995 ( 3.7A)
None
None
 0.36A 6fhwB-2f6dA:
45.5		 6fhwB-2f6dA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_B_ACRB801_2
(GLUCOAMYLASE P)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 4 TRP A 209
GLU A 210
GLU A 456
LEU A 471
 None
ACR  A 995 (-3.7A)
ACR  A 995 ( 4.6A)
None
 0.24A 6fhwB-2f6dA:
45.5		 6fhwB-2f6dA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 7 ARG A 156
GLU A 303
ASP A 300
GLU A 480
 None
 1.32A 6mn4F-2f6dA:
undetectable		 6mn4F-2f6dA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2f6d GLUCOAMYLASE GLU1
(Saccharomycopsis
fibuligera) 		4 / 6 ASP A 160
GLU A 303
ASP A 300
GLU A 480
 None
 1.15A 6mn5D-2f6dA:
undetectable		 6mn5D-2f6dA:
12.63