SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f6h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		3 / 3 ASP X 327
ARG X 330
ILE X 368
 None
 0.76A 1a4gB-2f6hX:
undetectable		 1a4gB-2f6hX:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		4 / 4 THR X 300
LEU X 299
LEU X 256
GLN X 184
 None
 0.96A 1fbmA-2f6hX:
undetectable		 1fbmA-2f6hX:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		3 / 3 THR X 300
LEU X 299
LEU X 256
 None
 0.62A 1mz9C-2f6hX:
undetectable		 1mz9C-2f6hX:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		3 / 3 TRP X 121
LEU X 114
LYS X 182
 None
 1.21A 1yajK-2f6hX:
undetectable		 1yajK-2f6hX:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		6 / 12 ALA X 123
ILE X 175
PHE X 168
PRO X 403
VAL X 248
ILE X 244
 None
 1.48A 2fxeA-2f6hX:
undetectable		 2fxeA-2f6hX:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		5 / 9 THR X 312
LEU X 283
VAL X 196
VAL X 260
ASP X 261
 None
 1.44A 2l8mA-2f6hX:
undetectable		 2l8mA-2f6hX:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		4 / 8 LEU X 275
LEU X 268
THR X 312
LEU X 316
 None
 0.67A 2xfhA-2f6hX:
1.4		 2xfhA-2f6hX:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		4 / 5 LEU X 180
ILE X 228
TRP X 293
TYR X 259
 None
 1.28A 2zlcA-2f6hX:
undetectable		 2zlcA-2f6hX:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		4 / 7 LEU X  99
SER X 172
ASN X 174
ASP X 167
 None
 0.95A 3lm8A-2f6hX:
undetectable
3lm8C-2f6hX:
undetectable		 3lm8A-2f6hX:
18.40
3lm8C-2f6hX:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		3 / 3 TYR X 176
LEU X 164
LYS X 165
 None
 0.76A 3sueD-2f6hX:
undetectable		 3sueD-2f6hX:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		4 / 5 LEU X 299
GLY X 302
PHE X 232
ASN X 258
 None
 1.06A 3uq6B-2f6hX:
undetectable		 3uq6B-2f6hX:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		4 / 8 PHE X 168
TYR X 129
VAL X 125
ILE X 175
 None
 1.07A 4a97D-2f6hX:
2.7		 4a97D-2f6hX:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		4 / 8 PHE X 168
TYR X 129
VAL X 125
ILE X 175
 None
 1.05A 4a97G-2f6hX:
1.7		 4a97G-2f6hX:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		4 / 7 PHE X 168
TYR X 129
VAL X 125
ILE X 175
 None
 1.07A 4a97H-2f6hX:
undetectable		 4a97H-2f6hX:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		5 / 9 GLY X  58
ALA X  57
ASP X  56
VAL X  68
ILE X 115
 None
 1.14A 4njtD-2f6hX:
undetectable		 4njtD-2f6hX:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		4 / 8 ILE X 244
GLY X 118
LEU X 183
LEU X 256
 None
 0.78A 5hs1A-2f6hX:
undetectable		 5hs1A-2f6hX:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		5 / 9 LEU X  95
VAL X 161
LEU X 164
ILE X  76
ALA X 135
 None
 1.20A 5og9A-2f6hX:
1.4		 5og9A-2f6hX:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		3 / 3 ALA X 170
VAL X 132
TYR X 129
 None
 0.39A 5zmqH-2f6hX:
undetectable		 5zmqH-2f6hX:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		4 / 6 PHE X 231
VAL X 253
LEU X 180
LEU X 183
 None
 0.99A 6e43D-2f6hX:
3.6		 6e43D-2f6hX:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		5 / 12 LEU X  95
LEU X  99
ALA X 135
SER X 138
LEU X  79
 None
 1.11A 6ew0B-2f6hX:
undetectable		 6ew0B-2f6hX:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		5 / 12 LEU X  95
LEU X  99
ALA X 135
SER X 138
LEU X  79
 None
 1.11A 6ew0D-2f6hX:
undetectable		 6ew0D-2f6hX:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		5 / 12 LEU X  95
LEU X  99
ALA X 135
SER X 138
LEU X  79
 None
 1.11A 6ew0H-2f6hX:
undetectable		 6ew0H-2f6hX:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 2f6h MYOSIN-2
(Saccharomyces
cerevisiae) 		5 / 12 LEU X  95
LEU X  99
ALA X 135
SER X 138
LEU X  79
 None
 1.11A 6ew0I-2f6hX:
undetectable		 6ew0I-2f6hX:
10.85