SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f6i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 2f6i ATP-DEPENDENT CLP
PROTEASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 10 ILE A 243
SER A 236
GLY A 240
LEU A 199
SER A 232
 None
 1.29A 3ik6B-2f6iA:
undetectable
3ik6E-2f6iA:
undetectable		 3ik6B-2f6iA:
22.18
3ik6E-2f6iA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 2f6i ATP-DEPENDENT CLP
PROTEASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 10 LEU A 199
SER A 232
ILE A 243
SER A 236
GLY A 240
 None
 1.45A 3ik6B-2f6iA:
undetectable
3ik6E-2f6iA:
undetectable		 3ik6B-2f6iA:
22.18
3ik6E-2f6iA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2f6i ATP-DEPENDENT CLP
PROTEASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 VAL A 268
SER A 272
LEU A 244
 None
 0.57A 3n8xA-2f6iA:
undetectable		 3n8xA-2f6iA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 2f6i ATP-DEPENDENT CLP
PROTEASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 10 LEU A 199
ALA A 263
GLY A 234
ILE A 203
PHE A 247
 None
 1.46A 3qpsA-2f6iA:
undetectable		 3qpsA-2f6iA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2f6i ATP-DEPENDENT CLP
PROTEASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 4 LEU A 189
ILE A 226
TYR A 198
TYR A 217
 None
 1.09A 3vt7A-2f6iA:
undetectable		 3vt7A-2f6iA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2f6i ATP-DEPENDENT CLP
PROTEASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 6 LEU A 270
ILE A 288
MET A 341
THR A 324
 None
 0.98A 4do3B-2f6iA:
undetectable		 4do3B-2f6iA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 2f6i ATP-DEPENDENT CLP
PROTEASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 LEU A 315
GLY A 240
LYS A 205
ALA A 208
ALA A 242
 None
 1.39A 4pclB-2f6iA:
undetectable		 4pclB-2f6iA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 2f6i ATP-DEPENDENT CLP
PROTEASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 ASP A 353
ILE A 351
ASP A 334
ILE A 286
SER A 258
 None
 1.18A 4uroA-2f6iA:
undetectable		 4uroA-2f6iA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2f6i ATP-DEPENDENT CLP
PROTEASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 PRO A 291
ILE A 237
LEU A 292
ILE A 269
LEU A 241
 None
 1.14A 5tiwA-2f6iA:
undetectable		 5tiwA-2f6iA:
22.30