SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 2f6r BIFUNCTIONAL
COENZYME A SYNTHASE
(Mus
musculus) 		3 / 3 VAL A 152
TRP A 150
TRP A 184
 None
ACO  A 270 (-3.9A)
ACO  A 270 (-4.2A)
 1.09A 1c4dA-2f6rA:
undetectable
1c4dB-2f6rA:
undetectable		 1c4dA-2f6rA:
3.70
1c4dB-2f6rA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 2f6r BIFUNCTIONAL
COENZYME A SYNTHASE
(Mus
musculus) 		5 / 9 VAL A 149
LEU A 145
LEU A 131
ARG A 128
ALA A 107
 None
ACO  A 270 ( 4.6A)
ACO  A 270 ( 4.3A)
ACO  A 270 (-4.3A)
None
 1.43A 1pbfA-2f6rA:
0.0		 1pbfA-2f6rA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2f6r BIFUNCTIONAL
COENZYME A SYNTHASE
(Mus
musculus) 		4 / 8 GLU A 190
LEU A  66
HIS A 189
LEU A 261
 None
 0.80A 2q0iA-2f6rA:
undetectable		 2q0iA-2f6rA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 2f6r BIFUNCTIONAL
COENZYME A SYNTHASE
(Mus
musculus) 		4 / 8 MET A 224
SER A  74
VAL A 191
GLY A  67
 None
 1.08A 2qd3A-2f6rA:
2.5		 2qd3A-2f6rA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2f6r BIFUNCTIONAL
COENZYME A SYNTHASE
(Mus
musculus) 		4 / 8 MET A 224
SER A  74
VAL A 191
GLY A  67
 None
 1.03A 4mk4A-2f6rA:
undetectable		 4mk4A-2f6rA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2f6r BIFUNCTIONAL
COENZYME A SYNTHASE
(Mus
musculus) 		4 / 8 MET A 224
VAL A 195
VAL A 191
GLY A  67
 None
 0.96A 4mk4A-2f6rA:
undetectable		 4mk4A-2f6rA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2f6r BIFUNCTIONAL
COENZYME A SYNTHASE
(Mus
musculus) 		4 / 6 THR A  69
LEU A  46
LEU A 256
GLU A 251
 None
 0.84A 5tudD-2f6rA:
undetectable		 5tudD-2f6rA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2f6r BIFUNCTIONAL
COENZYME A SYNTHASE
(Mus
musculus) 		4 / 8 SER A 222
MET A 178
TRP A 150
THR A 146
 ACO  A 270 ( 3.9A)
ACO  A 270 (-3.9A)
ACO  A 270 (-3.9A)
ACO  A 270 (-4.6A)
 1.26A 5u6nA-2f6rA:
4.3		 5u6nA-2f6rA:
22.27