SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f6x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 12 SER A1037
MET A1035
PRO A1081
GLY A1193
ASN A1216
 None
None
MPD  A4001 (-3.7A)
1GP  A3001 (-3.0A)
1GP  A3001 (-3.9A)
 1.49A 3jb2A-2f6xA:
undetectable		 3jb2A-2f6xA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 9 LEU A1050
ALA A1027
THR A1031
ALA A1033
THR A1010
 None
 1.30A 3mdtA-2f6xA:
undetectable		 3mdtA-2f6xA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 6 ALA A1148
ILE A1166
LEU A1127
GLU A1146
GLU A1180
 None
 1.23A 3r9sA-2f6xA:
2.3		 3r9sA-2f6xA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE
(Archaeoglobus
fulgidus) 		3 / 3 PRO A1081
THR A1082
LEU A1161
 MPD  A4001 (-3.7A)
None
None
 0.63A 3ttrA-2f6xA:
undetectable		 3ttrA-2f6xA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE
(Archaeoglobus
fulgidus) 		4 / 7 TYR A1219
ASN A1018
ILE A1218
PHE A1226
 None
 1.13A 3tvxB-2f6xA:
undetectable		 3tvxB-2f6xA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE
(Archaeoglobus
fulgidus) 		4 / 8 THR A1229
ILE A1213
LEU A1012
ILE A1022
 None
1GP  A3001 ( 4.6A)
None
None
 0.82A 4r38A-2f6xA:
undetectable		 4r38A-2f6xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE
(Archaeoglobus
fulgidus) 		4 / 8 THR A1229
ILE A1213
LEU A1012
ILE A1022
 None
1GP  A3001 ( 4.6A)
None
None
 0.75A 4r38D-2f6xA:
undetectable		 4r38D-2f6xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 10 ARG A1135
ALA A1132
GLY A1170
THR A1171
ALA A1134
 None
None
1GP  A3001 (-3.7A)
None
None
 1.28A 5vyhA-2f6xA:
undetectable		 5vyhA-2f6xA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A1123
PRO A1162
PHE A1159
THR A1082
VAL A1080
 None
None
None
None
MPD  A4001 (-4.5A)
 1.07A 5x6yA-2f6xA:
undetectable		 5x6yA-2f6xA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE
(Archaeoglobus
fulgidus) 		3 / 3 ALA A1025
VAL A1054
TYR A1057
 None
 0.68A 5zmqH-2f6xA:
undetectable		 5zmqH-2f6xA:
21.49