SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		6 / 12 ILE A 102
PHE A  79
LYS A  78
THR A 189
ILE A 190
ILE A 105
 None
 1.19A 1rx7A-2f7nA:
undetectable		 1rx7A-2f7nA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		4 / 7 VAL A 150
VAL A 154
LEU A 157
SER A 158
 None
 0.80A 3hs6B-2f7nA:
undetectable		 3hs6B-2f7nA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 12 TYR A  52
LEU A  53
ALA A  62
THR A  64
ALA A 174
 None
 1.28A 4fiaA-2f7nA:
undetectable		 4fiaA-2f7nA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 12 TYR A  52
LEU A  53
ALA A  62
THR A  64
ALA A 174
 None
 1.28A 4fiaA-2f7nA:
undetectable		 4fiaA-2f7nA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 12 ILE A 102
LYS A  78
THR A 189
ILE A 190
ILE A 105
 None
 0.96A 4kjjA-2f7nA:
undetectable		 4kjjA-2f7nA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 12 ILE A 102
LYS A  78
THR A 189
ILE A 190
ILE A 105
 None
 1.09A 4kjkA-2f7nA:
undetectable		 4kjkA-2f7nA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 12 ILE A 102
LYS A  78
THR A 189
ILE A 190
ILE A 105
 None
 0.98A 4kjlA-2f7nA:
undetectable		 4kjlA-2f7nA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 11 ILE A 102
PHE A  79
LYS A  78
ILE A 190
ILE A 105
 None
 1.28A 4p68A-2f7nA:
undetectable		 4p68A-2f7nA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 12 ILE A 102
PHE A  79
THR A 189
ILE A 190
ILE A 105
 None
 1.16A 4ptjA-2f7nA:
undetectable		 4ptjA-2f7nA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		3 / 3 MET A 196
GLN A 149
TYR A  82
 None
 0.90A 4udcA-2f7nA:
undetectable		 4udcA-2f7nA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		4 / 8 ARG A  89
ARG A 205
ASP A 203
ASP A 207
 SO4  A 301 (-3.6A)
SO4  A 301 (-3.7A)
None
None
 1.14A 4xqgB-2f7nA:
undetectable		 4xqgB-2f7nA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 12 ILE A 200
PHE A 101
ALA A 199
MET A 201
VAL A 154
 None
 1.28A 5n0xB-2f7nA:
undetectable		 5n0xB-2f7nA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		4 / 8 ALA A  38
VAL A  48
THR A  42
GLY A 121
 CO  A 210 ( 4.3A)
None
None
None
 0.98A 5v0vA-2f7nA:
2.9		 5v0vA-2f7nA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 12 ALA A  97
PHE A  79
LYS A  78
THR A 189
ILE A 190
 None
 1.34A 5z6fA-2f7nA:
undetectable		 5z6fA-2f7nA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA606_1
(SERUM ALBUMIN)		 2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 12 TYR A 164
VAL A 136
SER A  74
LEU A  75
SER A 108
 None
 1.44A 6ci6A-2f7nA:
undetectable		 6ci6A-2f7nA:
16.24