SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 2f8a GLUTATHIONE
PEROXIDASE 1
(Homo
sapiens) 		3 / 3 ALA A 125
VAL A 115
TRP A 150
 None
 0.99A 1tkqA-2f8aA:
undetectable		 1tkqA-2f8aA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2f8a GLUTATHIONE
PEROXIDASE 1
(Homo
sapiens) 		4 / 5 LEU A  38
PRO A 173
VAL A 167
ILE A  40
 None
 0.95A 2aoiB-2f8aA:
undetectable		 2aoiB-2f8aA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 2f8a GLUTATHIONE
PEROXIDASE 1
(Homo
sapiens) 		4 / 6 SER A 135
ASP A 189
TYR A 177
PRO A 173
 None
 1.46A 3jqaB-2f8aA:
undetectable		 3jqaB-2f8aA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 2f8a GLUTATHIONE
PEROXIDASE 1
(Homo
sapiens) 		3 / 3 PRO A  75
SER A  45
ASN A  77
 None
 0.87A 3lslG-2f8aA:
undetectable		 3lslG-2f8aA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2f8a GLUTATHIONE
PEROXIDASE 1
(Homo
sapiens) 		3 / 3 ASN A  87
LEU A  94
PHE A 110
 None
 0.78A 4dajB-2f8aA:
undetectable		 4dajB-2f8aA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2f8a GLUTATHIONE
PEROXIDASE 1
(Homo
sapiens) 		5 / 10 GLY A  65
ASN A 106
ILE A 190
LEU A  64
LEU A  69
 None
 1.22A 4xj7A-2f8aA:
undetectable
4xj7B-2f8aA:
undetectable		 4xj7A-2f8aA:
22.85
4xj7B-2f8aA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 2f8a GLUTATHIONE
PEROXIDASE 1
(Homo
sapiens) 		3 / 3 LEU A  69
ARG A  67
ARG A  63
 None
 0.92A 4yiaB-2f8aA:
undetectable		 4yiaB-2f8aA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2f8a GLUTATHIONE
PEROXIDASE 1
(Homo
sapiens) 		3 / 3 ASN A  87
LEU A  94
PHE A 110
 None
 0.78A 5dsgA-2f8aA:
undetectable		 5dsgA-2f8aA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2f8a GLUTATHIONE
PEROXIDASE 1
(Homo
sapiens) 		3 / 3 GLU A 163
TRP A 160
ASN A 116
 None
MLA  A 501 (-4.1A)
None
 1.01A 5dv4A-2f8aA:
undetectable		 5dv4A-2f8aA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2f8a GLUTATHIONE
PEROXIDASE 1
(Homo
sapiens) 		5 / 12 PHE A 110
HIS A 121
LEU A 123
VAL A  14
GLY A  31
 None
 1.41A 5i8fA-2f8aA:
undetectable		 5i8fA-2f8aA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2f8a GLUTATHIONE
PEROXIDASE 1
(Homo
sapiens) 		5 / 12 VAL A  51
THR A  55
VAL A  97
GLY A 100
PHE A 107
 None
 0.99A 6a94B-2f8aA:
undetectable		 6a94B-2f8aA:
17.94