SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f8l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
5 / 8 LEU A 321
ALA A 306
GLY A 269
ILE A 289
ILE A 320
None
1.49A 1d4yB-2f8lA:
undetectable
1d4yB-2f8lA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
4 / 6 LEU A 123
ASP A 191
MET A 174
LEU A 176
None
1.18A 1errB-2f8lA:
undetectable
1errB-2f8lA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
4 / 7 PHE A 249
ALA A 306
LEU A 305
VAL A 303
None
0.93A 1hk2A-2f8lA:
undetectable
1hk2A-2f8lA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
5 / 12 GLY A 128
ASP A 156
LEU A 159
ASP A 180
PRO A 198
SAM  A 400 (-3.3A)
None
SAM  A 400 (-4.3A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.8A)
0.70A 1qaoA-2f8lA:
12.4
1qaoA-2f8lA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
3 / 3 PRO A 125
ASP A 154
ASP A 180
None
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
0.78A 1sqfA-2f8lA:
11.8
1sqfA-2f8lA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
5 / 11 ALA A 126
ASP A 156
ASP A 180
PRO A 198
PHE A 226
SAM  A 400 (-3.4A)
None
SAM  A 400 (-3.4A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.9A)
0.59A 2admA-2f8lA:
19.9
2admA-2f8lA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
5 / 11 THR A  98
ALA A 126
ASP A 180
PRO A 198
PHE A 226
SAM  A 400 (-3.8A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.9A)
1.06A 2admA-2f8lA:
19.9
2admA-2f8lA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
5 / 11 THR A  98
ALA A 126
ASP A 180
PRO A 198
PHE A 226
SAM  A 400 (-3.8A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.9A)
1.07A 2admB-2f8lA:
20.0
2admB-2f8lA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
4 / 7 GLY A 181
ASP A 204
TYR A 202
THR A 210
SAM  A 400 (-3.6A)
None
None
None
1.13A 2aouB-2f8lA:
13.2
2aouB-2f8lA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
4 / 8 ILE A 122
SER A 121
ASP A 191
LEU A 110
None
0.95A 2cdqA-2f8lA:
undetectable
2cdqA-2f8lA:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
12 / 12 HIS A  95
ALA A 126
GLY A 128
ASN A 131
LEU A 132
VAL A 155
ASP A 156
LEU A 159
GLY A 181
ASP A 196
PRO A 198
PHE A 226
SAM  A 400 (-4.5A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.3A)
None
SAM  A 400 (-4.1A)
SAM  A 400 (-4.2A)
None
SAM  A 400 (-4.3A)
SAM  A 400 (-3.6A)
SAM  A 400 (-3.7A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.9A)
0.04A 2f8lA-2f8lA:
56.4
2f8lA-2f8lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
8 / 12 HIS A  95
ALA A 126
GLY A 128
LEU A 133
VAL A 155
ASP A 156
LEU A 159
PHE A 226
SAM  A 400 (-4.5A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.3A)
None
SAM  A 400 (-4.2A)
None
SAM  A 400 (-4.3A)
SAM  A 400 (-4.9A)
1.43A 2f8lA-2f8lA:
56.4
2f8lA-2f8lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
4 / 4 THR A  98
THR A 129
ASP A 154
ASP A 180
SAM  A 400 (-3.8A)
SAM  A 400 (-2.9A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
0.03A 2f8lA-2f8lA:
56.4
2f8lA-2f8lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
4 / 6 THR A  98
THR A 129
ASP A 154
ASP A 180
SAM  A 400 (-3.8A)
SAM  A 400 (-2.9A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
0.41A 2okcA-2f8lA:
25.5
2okcA-2f8lA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
4 / 6 THR A  98
THR A 129
ASP A 154
ASP A 180
SAM  A 400 (-3.8A)
SAM  A 400 (-2.9A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
0.50A 2okcB-2f8lA:
25.2
2okcB-2f8lA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
4 / 5 LEU A 123
ASP A 191
MET A 174
LEU A 176
None
1.21A 2qxsA-2f8lA:
undetectable
2qxsA-2f8lA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
4 / 5 LEU A 123
ASP A 191
MET A 174
LEU A 176
None
1.22A 2qxsB-2f8lA:
undetectable
2qxsB-2f8lA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
4 / 7 ALA A 126
GLY A 128
ASP A 154
ASP A 180
SAM  A 400 (-3.4A)
SAM  A 400 (-3.3A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
0.75A 2uyqA-2f8lA:
9.9
2uyqA-2f8lA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
4 / 7 LEU A 308
ILE A 105
GLN A 139
ILE A 122
None
0.83A 2xkwA-2f8lA:
undetectable
2xkwA-2f8lA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
7 / 12 THR A  98
ALA A 126
GLY A 128
THR A 129
LEU A 182
PRO A 198
PHE A 226
SAM  A 400 (-3.8A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.3A)
SAM  A 400 (-2.9A)
SAM  A 400 ( 4.8A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.9A)
0.91A 2y7hB-2f8lA:
23.3
2y7hB-2f8lA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
7 / 12 THR A  98
ALA A 126
GLY A 128
THR A 129
LEU A 182
PRO A 198
PHE A 226
SAM  A 400 (-3.8A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.3A)
SAM  A 400 (-2.9A)
SAM  A 400 ( 4.8A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.9A)
0.91A 2y7hC-2f8lA:
23.4
2y7hC-2f8lA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
3 / 3 ASP A 154
ASP A 180
ASP A 196
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.7A)
0.60A 3douA-2f8lA:
10.6
3douA-2f8lA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
4 / 8 SER A 195
VAL A 193
PHE A 226
VAL A 190
None
None
SAM  A 400 (-4.9A)
None
0.99A 3fhxB-2f8lA:
2.7
3fhxB-2f8lA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
5 / 12 HIS A 266
GLY A 238
LEU A 240
VAL A 113
GLN A 115
GOL  A 401 ( 4.7A)
None
None
None
None
1.29A 3fzgA-2f8lA:
9.5
3fzgA-2f8lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
3 / 3 GLY A 128
ASP A 154
ASP A 180
SAM  A 400 (-3.3A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
0.47A 3ou7C-2f8lA:
9.9
3ou7C-2f8lA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
5 / 11 GLY A 128
ASP A 154
ASP A 156
ASP A 180
PRO A 198
SAM  A 400 (-3.3A)
SAM  A 400 (-2.7A)
None
SAM  A 400 (-3.4A)
SAM  A 400 (-3.8A)
0.56A 3v8vB-2f8lA:
10.3
3v8vB-2f8lA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
4 / 7 PHE A 241
PHE A 328
GLY A 269
ILE A 324
None
GOL  A 401 (-4.9A)
None
None
0.81A 4ejjA-2f8lA:
undetectable
4ejjA-2f8lA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
5 / 12 ASP A 124
LEU A 123
GLY A 181
PHE A 226
LEU A 197
SAM  A 400 ( 4.8A)
None
SAM  A 400 (-3.6A)
SAM  A 400 (-4.9A)
None
1.05A 4retA-2f8lA:
undetectable
4retA-2f8lA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
5 / 12 ASP A 124
LEU A 123
GLY A 181
PHE A 226
LEU A 197
SAM  A 400 ( 4.8A)
None
SAM  A 400 (-3.6A)
SAM  A 400 (-4.9A)
None
1.05A 4retC-2f8lA:
2.6
4retC-2f8lA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
5 / 12 TYR A 233
ASN A 207
LEU A 185
LEU A 123
PHE A 226
None
None
None
None
SAM  A 400 (-4.9A)
1.32A 4rtbA-2f8lA:
undetectable
4rtbA-2f8lA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
4 / 4 ASP A 124
GLY A 128
ASP A 154
ASP A 180
SAM  A 400 ( 4.8A)
SAM  A 400 (-3.3A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
0.43A 5e72A-2f8lA:
15.9
5e72A-2f8lA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
5 / 12 LEU A 243
ILE A 271
THR A 135
ALA A 107
LEU A 109
None
1.21A 5ienA-2f8lA:
undetectable
5ienA-2f8lA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
5 / 12 LEU A 308
ILE A 105
GLN A 139
ILE A 114
ILE A 324
None
0.94A 5y2tB-2f8lA:
undetectable
5y2tB-2f8lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
5 / 12 ALA A 126
GLY A 128
THR A 129
LEU A 182
PHE A 226
SAM  A 400 (-3.4A)
SAM  A 400 (-3.3A)
SAM  A 400 (-2.9A)
SAM  A 400 ( 4.8A)
SAM  A 400 (-4.9A)
0.74A 5ybbA-2f8lA:
25.2
5ybbA-2f8lA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes)
6 / 12 THR A  98
ASP A 124
THR A 129
LEU A 182
PRO A 198
PHE A 226
SAM  A 400 (-3.8A)
SAM  A 400 ( 4.8A)
SAM  A 400 (-2.9A)
SAM  A 400 ( 4.8A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.9A)
0.66A 5ybbB-2f8lA:
25.3
5ybbB-2f8lA:
22.13