SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f8m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 2f8m RIBOSE 5-PHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		5 / 12 ALA A 102
GLY A 100
THR A  55
SER A  56
GLY A 120
 None
 1.07A 2hw2A-2f8mA:
undetectable		 2hw2A-2f8mA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 2f8m RIBOSE 5-PHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		5 / 12 GLY A 134
ASP A 183
ILE A 138
GLY A 210
THR A 196
 None
 0.79A 2nmyA-2f8mA:
undetectable		 2nmyA-2f8mA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 2f8m RIBOSE 5-PHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		5 / 11 GLY A 134
ASP A 183
ILE A 138
GLY A 210
THR A 196
 None
 0.83A 2nnpA-2f8mA:
undetectable		 2nnpA-2f8mA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2f8m RIBOSE 5-PHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		3 / 3 ASP A 176
ASN A 177
THR A 142
 None
 0.46A 2pymB-2f8mA:
undetectable		 2pymB-2f8mA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2f8m RIBOSE 5-PHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		3 / 3 ASP A 176
ASN A 177
THR A 142
 None
 0.52A 2q63B-2f8mA:
undetectable		 2q63B-2f8mA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2f8m RIBOSE 5-PHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		3 / 3 SER A  56
GLY A  26
GLY A  28
 None
None
PO4  A 700 ( 3.9A)
 0.52A 3bogA-2f8mA:
undetectable
3bogC-2f8mA:
undetectable		 3bogA-2f8mA:
undetectable
3bogC-2f8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2f8m RIBOSE 5-PHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		6 / 12 GLY A 210
GLY A  98
ILE A 138
LEU A  95
THR A  86
GLU A  88
 None
 1.09A 3ckkA-2f8mA:
undetectable		 3ckkA-2f8mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 2f8m RIBOSE 5-PHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		5 / 12 GLY A 134
ASP A 183
ILE A 138
GLY A 210
THR A 196
 None
 0.81A 3d1xA-2f8mA:
undetectable		 3d1xA-2f8mA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 2f8m RIBOSE 5-PHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		5 / 12 GLY A 134
ASP A 183
ILE A 138
GLY A 210
THR A 196
 None
 0.85A 3d1yA-2f8mA:
undetectable		 3d1yA-2f8mA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 2f8m RIBOSE 5-PHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		5 / 12 GLY A 134
ASP A 183
ILE A 138
GLY A 210
THR A 196
 None
 0.80A 3el4A-2f8mA:
undetectable		 3el4A-2f8mA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2f8m RIBOSE 5-PHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		5 / 12 LEU A 108
VAL A 109
SER A 112
SER A  77
LEU A  70
 None
 1.28A 3vt7A-2f8mA:
undetectable		 3vt7A-2f8mA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 2f8m RIBOSE 5-PHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		4 / 5 SER A  56
GLU A 106
THR A  59
ASP A  84
 None
 1.23A 3zs3A-2f8mA:
0.0		 3zs3A-2f8mA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 2f8m RIBOSE 5-PHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		5 / 9 LEU A  42
ILE A  83
GLY A  24
ILE A  53
ILE A  38
 None
 1.16A 5kr2D-2f8mA:
undetectable		 5kr2D-2f8mA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2f8m RIBOSE 5-PHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		3 / 3 LEU A 130
ASP A 183
ILE A 138
 None
 0.57A 6dh0B-2f8mA:
undetectable		 6dh0B-2f8mA:
22.75