SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		3 / 3 VAL A  88
VAL A 150
TRP A 166
 None
 0.93A 1av2C-2f8qA:
undetectable
1av2D-2f8qA:
undetectable		 1av2C-2f8qA:
3.78
1av2D-2f8qA:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		4 / 8 SER A 164
VAL A 165
LEU A 122
TYR A 174
 None
 0.89A 1fduB-2f8qA:
undetectable		 1fduB-2f8qA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		4 / 6 SER A 164
VAL A 165
LEU A 122
TYR A 174
 None
 0.92A 1fduD-2f8qA:
undetectable		 1fduD-2f8qA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		4 / 6 PRO A   3
PHE A   4
GLN A   7
VAL A  37
 None
 1.21A 1l2iB-2f8qA:
undetectable		 1l2iB-2f8qA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		4 / 7 TYR A  42
THR A 318
GLU A  48
VAL A  37
 None
 1.19A 1tv8A-2f8qA:
6.6		 1tv8A-2f8qA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		4 / 8 TYR A  42
THR A 318
GLU A  48
VAL A  37
 None
 1.18A 2fb2A-2f8qA:
5.8		 2fb2A-2f8qA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		4 / 7 TYR A  42
THR A 318
GLU A  48
VAL A  37
 None
 1.18A 2fb2B-2f8qA:
2.9		 2fb2B-2f8qA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		5 / 12 THR A 258
VAL A 257
LEU A 297
ILE A 241
SER A 244
 None
 1.42A 2fj1A-2f8qA:
0.5		 2fj1A-2f8qA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		3 / 3 VAL A  88
VAL A 150
TRP A 166
 None
 0.85A 3l8lA-2f8qA:
undetectable
3l8lB-2f8qA:
undetectable		 3l8lA-2f8qA:
3.78
3l8lB-2f8qA:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		4 / 8 ASN A 328
ASP A 334
SER A 263
GLU A 282
 None
 1.07A 3sg9B-2f8qA:
0.6		 3sg9B-2f8qA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		4 / 7 ALA A 335
TYR A 265
ARG A 323
ALA A 324
 None
 1.08A 3twpA-2f8qA:
undetectable		 3twpA-2f8qA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		3 / 3 VAL A 262
TRP A 311
TRP A 319
 None
 1.34A 3zq8A-2f8qA:
undetectable
3zq8B-2f8qA:
undetectable		 3zq8A-2f8qA:
3.78
3zq8B-2f8qA:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		4 / 5 ASN A 328
ALA A 272
GLY A 332
ASP A 334
 None
 1.01A 4n48A-2f8qA:
undetectable		 4n48A-2f8qA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		4 / 5 ILE A 313
VAL A  25
PHE A  84
HIS A  41
 None
 1.22A 4rzvA-2f8qA:
undetectable		 4rzvA-2f8qA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		3 / 3 GLU A  26
ILE A  54
ALA A  68
 None
 0.65A 4wnwB-2f8qA:
undetectable		 4wnwB-2f8qA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		4 / 5 ASP A 196
VAL A 212
PHE A 248
GLY A 224
 None
 1.00A 4xp6A-2f8qA:
undetectable		 4xp6A-2f8qA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		3 / 3 VAL A  37
TYR A 343
ALA A   5
 None
 0.57A 4ybnA-2f8qA:
undetectable		 4ybnA-2f8qA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		3 / 3 ARG A 290
PRO A 236
TYR A 298
 None
 1.03A 5tzoB-2f8qA:
undetectable		 5tzoB-2f8qA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		5 / 10 SER A 244
LEU A 294
LEU A 301
ILE A 231
PRO A 236
 None
 1.50A 6dm1B-2f8qA:
undetectable
6dm1C-2f8qA:
undetectable		 6dm1B-2f8qA:
11.11
6dm1C-2f8qA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		5 / 10 SER A 244
LEU A 294
LEU A 301
ILE A 231
PRO A 236
 None
 1.46A 6dm2B-2f8qA:
undetectable
6dm2C-2f8qA:
undetectable		 6dm2B-2f8qA:
11.11
6dm2C-2f8qA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		5 / 10 ILE A 231
PRO A 236
SER A 244
LEU A 294
LEU A 301
 None
 1.45A 6dm2A-2f8qA:
undetectable
6dm2D-2f8qA:
undetectable		 6dm2A-2f8qA:
11.11
6dm2D-2f8qA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		3 / 3 VAL A  25
GLU A  48
ILE A  71
 None
 0.63A 6f7lB-2f8qA:
undetectable		 6f7lB-2f8qA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE
(Bacillus
sp.
NG-27) 		3 / 3 LYS A 204
VAL A 151
ASP A 153
 None
 0.70A 6fgdA-2f8qA:
undetectable		 6fgdA-2f8qA:
23.34