SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 12 LEU A 528
HIS A 680
SER A 682
ILE A 685
PHE A 518
 None
 1.25A 1ot7B-2f8tA:
0.0		 1ot7B-2f8tA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 12 LEU A 457
VAL A 359
ILE A 395
SER A 393
LEU A 446
 None
 1.17A 1s19A-2f8tA:
undetectable		 1s19A-2f8tA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		4 / 7 THR A 678
LEU A 662
VAL A 643
ILE A 641
 None
 0.93A 1t87B-2f8tA:
undetectable		 1t87B-2f8tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		4 / 5 GLU A 425
THR A 460
LEU A 461
LEU A 457
 None
 1.23A 1u18B-2f8tA:
undetectable		 1u18B-2f8tA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 11 PHE A  88
PHE A  21
GLY A 302
LEU A 100
PHE A  91
 None
 0.89A 1z11A-2f8tA:
undetectable		 1z11A-2f8tA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 11 PHE A  88
PHE A  21
GLY A 302
LEU A 100
PHE A  91
 None
 0.92A 1z11B-2f8tA:
undetectable		 1z11B-2f8tA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		4 / 5 LEU A 407
ILE A 395
LEU A 394
SER A 393
 None
 0.80A 2byoA-2f8tA:
undetectable		 2byoA-2f8tA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 7 ALA A  60
GLY A  61
ASP A 103
LEU A 100
ARG A  39
 None
 1.27A 2uyqA-2f8tA:
2.1		 2uyqA-2f8tA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 10 THR A 544
GLY A 549
PHE A 582
GLU A 545
ILE A 501
 None
 1.20A 3kvrB-2f8tA:
2.5		 3kvrB-2f8tA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		4 / 6 ILE A 613
GLU A 610
ALA A   5
ASN A 609
 None
 0.94A 3pgyA-2f8tA:
undetectable
3pgyB-2f8tA:
undetectable		 3pgyA-2f8tA:
19.78
3pgyB-2f8tA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 12 ILE A 115
PHE A 114
ILE A 138
LEU A 157
LEU A 159
 U  C  25 ( 4.6A)
None
U  C  25 ( 4.2A)
None
None
 1.23A 3s79A-2f8tA:
undetectable		 3s79A-2f8tA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		3 / 3 TYR A 304
LEU A 146
LYS A 147
 None
 0.61A 3sueD-2f8tA:
undetectable		 3sueD-2f8tA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 11 PHE A  88
PHE A  21
GLY A 302
LEU A 100
PHE A  91
 None
 0.98A 3t3rA-2f8tA:
undetectable		 3t3rA-2f8tA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		4 / 8 TYR A 704
THR A 686
TYR A 531
TRP A 705
 None
 1.33A 3wipD-2f8tA:
undetectable
3wipE-2f8tA:
undetectable		 3wipD-2f8tA:
15.66
3wipE-2f8tA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 12 GLU A 445
VAL A 359
ILE A 357
ILE A 408
GLU A 405
 None
 1.25A 4a99A-2f8tA:
undetectable
4a99C-2f8tA:
undetectable		 4a99A-2f8tA:
20.76
4a99C-2f8tA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		4 / 7 PHE A  88
GLY A 302
LEU A 100
PHE A  91
 None
 0.71A 4ejjD-2f8tA:
undetectable		 4ejjD-2f8tA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		3 / 3 ASP A 577
ARG A 644
THR A 544
 None
 0.83A 4i13A-2f8tA:
undetectable		 4i13A-2f8tA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		4 / 7 PHE A 346
ILE A 484
TYR A 667
ASN A 523
 None
 1.44A 4o7gA-2f8tA:
undetectable
4o7gB-2f8tA:
undetectable		 4o7gA-2f8tA:
16.05
4o7gB-2f8tA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		3 / 3 LEU A 396
LEU A 438
ASN A 458
 None
 0.73A 4otwA-2f8tA:
undetectable		 4otwA-2f8tA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		3 / 3 ASP A 577
ARG A 644
THR A 544
 None
 0.86A 4p3rA-2f8tA:
undetectable		 4p3rA-2f8tA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		3 / 4 ARG A 573
GLY A 572
GLU A 597
 None
 0.56A 4z2dB-2f8tA:
undetectable
4z2dC-2f8tA:
2.1		 4z2dB-2f8tA:
22.07
4z2dC-2f8tA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		3 / 3 TYR A 532
THR A 534
THR A 519
 None
 0.39A 5aoxB-2f8tA:
undetectable		 5aoxB-2f8tA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		3 / 3 TYR A 532
THR A 534
THR A 519
 None
 0.36A 5aoxE-2f8tA:
1.4		 5aoxE-2f8tA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		3 / 3 TRP A  40
ILE A 190
SER A 222
 None
 1.01A 5gqbA-2f8tA:
undetectable		 5gqbA-2f8tA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		4 / 5 PHE A 560
GLY A 526
ASP A 496
ILE A 566
 None
 1.00A 5ik1A-2f8tA:
undetectable		 5ik1A-2f8tA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 7 PHE A 560
GLY A 526
VAL A 495
ASP A 496
ILE A 566
 None
 1.29A 5ik1A-2f8tA:
undetectable		 5ik1A-2f8tA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 12 ILE A 115
PHE A 114
ILE A 138
LEU A 157
LEU A 159
 U  C  25 ( 4.6A)
None
U  C  25 ( 4.2A)
None
None
 1.22A 5jkvA-2f8tA:
undetectable		 5jkvA-2f8tA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 12 ILE A 395
VAL A 420
SER A 358
TYR A 427
ALA A 397
 None
 1.08A 5n0oA-2f8tA:
undetectable		 5n0oA-2f8tA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 12 ILE A 395
VAL A 420
SER A 358
TYR A 427
ALA A 397
 None
 1.09A 5n0oB-2f8tA:
3.0		 5n0oB-2f8tA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 12 ILE A 395
VAL A 420
SER A 358
TYR A 427
ALA A 397
 None
 1.09A 5n0sB-2f8tA:
undetectable		 5n0sB-2f8tA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 12 ILE A 685
SER A 669
ILE A 484
ALA A 479
LEU A 706
 None
 1.31A 5oy02-2f8tA:
undetectable		 5oy02-2f8tA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		4 / 6 ARG A 236
TRP A 226
PHE A 210
GLU A 227
 None
 1.46A 5unvA-2f8tA:
undetectable
5unvB-2f8tA:
undetectable		 5unvA-2f8tA:
20.03
5unvB-2f8tA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		4 / 6 TRP A 226
PHE A 210
GLU A 227
ARG A 236
 None
 1.50A 5uo8A-2f8tA:
0.0
5uo8B-2f8tA:
0.0		 5uo8A-2f8tA:
20.64
5uo8B-2f8tA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		4 / 7 ARG A 236
TRP A 226
PHE A 210
GLU A 227
 None
 1.46A 5vujA-2f8tA:
undetectable
5vujB-2f8tA:
undetectable		 5vujA-2f8tA:
20.03
5vujB-2f8tA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		5 / 10 LEU A 528
VAL A 499
TYR A 531
TYR A 532
GLY A 500
 None
 1.24A 6bsiA-2f8tA:
2.5		 6bsiA-2f8tA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		3 / 3 THR A 544
ALA A 581
LYS A 583
 None
 0.71A 6fgcA-2f8tA:
undetectable		 6fgcA-2f8tA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 2f8t ARGONAUTE PROTEIN
(Aquifex
aeolicus) 		3 / 3 THR A 544
ALA A 581
LYS A 583
 None
 0.67A 6fgdA-2f8tA:
6.7		 6fgdA-2f8tA:
21.73