SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f91'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		8 / 8 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 227
 None
 0.51A 1aq7A-2f91A:
36.4		 1aq7A-2f91A:
44.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		6 / 9 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 227
 None
 0.39A 1bcuH-2f91A:
35.2		 1bcuH-2f91A:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 227
 None
 0.40A 1dwcH-2f91A:
34.3		 1dwcH-2f91A:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		8 / 12 HIS A  57
LEU A  99
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 227
 None
 0.50A 1etrH-2f91A:
34.4		 1etrH-2f91A:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 227
 None
 0.40A 1f5lA-2f91A:
36.8		 1f5lA-2f91A:
34.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		5 / 10 SER A 195
SER A 214
ILE A 212
GLY A 211
GLY A 227
 None
 1.29A 1mehA-2f91A:
undetectable		 1mehA-2f91A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		4 / 5 VAL A 138
THR A 139
GLN A  30
ILE A 121
 None
 1.39A 1ss4A-2f91A:
0.0		 1ss4A-2f91A:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 227
 None
 0.25A 1tnlA-2f91A:
36.6		 1tnlA-2f91A:
44.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		5 / 11 THR A 139
THR A 159
GLY A 211
ALA A 200
SER A 190
 None
CL  A 408 (-4.9A)
None
None
None
 1.14A 2f162-2f91A:
undetectable		 2f162-2f91A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		5 / 11 THR A 139
THR A 159
GLY A 211
ALA A 200
SER A 190
 None
CL  A 408 (-4.9A)
None
None
None
 1.14A 2f16N-2f91A:
undetectable		 2f16N-2f91A:
24.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 227
 None
 0.26A 2otvA-2f91A:
36.8		 2otvA-2f91A:
44.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		7 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 227
TYR A 229
 None
 0.36A 2p16A-2f91A:
36.3		 2p16A-2f91A:
37.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		4 / 7 ILE A  88
SER A 104
PHE A  33
ILE A  66
 None
 1.05A 2q6hA-2f91A:
undetectable		 2q6hA-2f91A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		4 / 7 ILE A  88
SER A 104
PHE A  33
ILE A  66
 None
 1.04A 2qb4A-2f91A:
undetectable		 2qb4A-2f91A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		4 / 8 ILE A 181
GLY A 211
LEU A 209
LEU A 123
 CD  A 405 ( 4.9A)
None
None
None
 0.86A 2vctA-2f91A:
undetectable		 2vctA-2f91A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		4 / 8 ILE A 181
GLY A 211
LEU A 209
LEU A 123
 CD  A 405 ( 4.9A)
None
None
None
 0.88A 2vctB-2f91A:
undetectable		 2vctB-2f91A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		4 / 8 ILE A 181
GLY A 211
LEU A 209
LEU A 123
 CD  A 405 ( 4.9A)
None
None
None
 0.89A 2vctC-2f91A:
undetectable		 2vctC-2f91A:
21.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 227
 None
 0.33A 2vinA-2f91A:
37.1		 2vinA-2f91A:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		8 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 218
GLY A 227
TYR A 229
 None
 0.41A 2w26A-2f91A:
36.4		 2w26A-2f91A:
37.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		5 / 8 LEU A  99
ASP A 102
GLY A  56
ALA A  55
VAL A 213
 None
 1.18A 3ekpA-2f91A:
undetectable		 3ekpA-2f91A:
16.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		9 / 11 HIS A  57
LEU A  99
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 227
 None
 0.43A 3gy3A-2f91A:
36.4		 3gy3A-2f91A:
44.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		5 / 12 THR A 139
THR A 159
GLY A 211
ALA A 200
SER A 190
 None
CL  A 408 (-4.9A)
None
None
None
 1.13A 3mg02-2f91A:
undetectable
3mg0V-2f91A:
undetectable		 3mg02-2f91A:
24.79
3mg0V-2f91A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		5 / 11 THR A 139
THR A 159
GLY A 211
ALA A 200
SER A 190
 None
CL  A 408 (-4.9A)
None
None
None
 1.12A 3mg0N-2f91A:
undetectable		 3mg0N-2f91A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		5 / 12 LYS A  16
GLY A 197
PHE A  33
ALA A  55
ASP A 194
 None
 0.94A 3nvkI-2f91A:
undetectable		 3nvkI-2f91A:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		6 / 6 SER A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 227
 None
 0.36A 3rxfA-2f91A:
14.6		 3rxfA-2f91A:
44.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		5 / 5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 227
 None
 0.34A 3rxhA-2f91A:
36.8		 3rxhA-2f91A:
44.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		5 / 12 GLU A  77
LEU A  24
GLN A  81
VAL A  67
ALA A  68
 CD  A 401 (-3.2A)
None
None
None
None
 0.93A 3t7vA-2f91A:
undetectable		 3t7vA-2f91A:
25.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
 None
 0.89A 4fu8A-2f91A:
36.6		 4fu8A-2f91A:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		5 / 12 HIS A  57
LEU A  99
ASP A 189
GLY A 216
GLY A 227
 None
 0.39A 4hfpB-2f91A:
35.1		 4hfpB-2f91A:
36.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		6 / 12 HIS A  57
LEU A  99
ASP A 189
VAL A 213
TRP A 215
GLY A 227
 None
 0.35A 4hfpD-2f91A:
34.3		 4hfpD-2f91A:
36.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		5 / 8 ASP A 189
ALA A 220
GLY A 223
PRO A 161
VAL A 160
 None
None
None
CL  A 408 (-4.5A)
CL  A 408 ( 4.7A)
 1.36A 4ll3A-2f91A:
undetectable		 4ll3A-2f91A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		5 / 9 LEU A  99
ASP A 102
GLY A  56
ALA A  55
VAL A 213
 None
 1.15A 4njtD-2f91A:
undetectable		 4njtD-2f91A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		4 / 7 LEU A  31
ILE A 103
ILE A 212
VAL A 232
 None
 0.86A 4ojbA-2f91A:
undetectable		 4ojbA-2f91A:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		6 / 12 HIS A  57
LEU A  99
VAL A 213
TRP A 215
GLY A 216
GLY A 227
 None
 0.33A 4rn6B-2f91A:
28.8		 4rn6B-2f91A:
36.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		5 / 9 PHE A  41
GLY A  43
THR A  54
LEU A 106
LEU A 108
 None
 1.38A 4ze0A-2f91A:
undetectable		 4ze0A-2f91A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 2f91 HEPATOPANCREAS
TRYPSIN
(Astacus
leptodactylus) 		6 / 12 GLY A  18
GLY A 184
GLY A 186
GLU A 186
ASP A 167
VAL A 163
 None
 1.41A 5m5bA-2f91A:
undetectable		 5m5bA-2f91A:
21.83