SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f96'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2f96 RIBONUCLEASE T
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 203
GLY A 208
ILE A 209
VAL A  56
 None
 0.77A 1d4sB-2f96A:
undetectable		 1d4sB-2f96A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2f96 RIBONUCLEASE T
(Pseudomonas
aeruginosa) 		4 / 7 PHE A  26
LEU A  64
PHE A 206
GLY A  62
 None
 0.98A 2v0mC-2f96A:
undetectable		 2v0mC-2f96A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2f96 RIBONUCLEASE T
(Pseudomonas
aeruginosa) 		4 / 6 GLU A 104
THR A  45
ALA A 144
ALA A 143
 None
 1.20A 3ns1C-2f96A:
undetectable		 3ns1C-2f96A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2f96 RIBONUCLEASE T
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 140
THR A  45
ALA A 144
ALA A 143
 None
 1.25A 3ns1C-2f96A:
undetectable		 3ns1C-2f96A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S7S_A_EXMA601_1
(CYTOCHROME P450 19A1)		 2f96 RIBONUCLEASE T
(Pseudomonas
aeruginosa) 		5 / 9 ILE A  51
ALA A 195
ASP A  35
THR A 199
LEU A 129
 None
None
MG  A2001 (-2.5A)
None
None
 1.10A 3s7sA-2f96A:
0.0		 3s7sA-2f96A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2f96 RIBONUCLEASE T
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 205
ILE A 209
ARG A 212
 None
 0.66A 4mk4B-2f96A:
undetectable		 4mk4B-2f96A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 2f96 RIBONUCLEASE T
(Pseudomonas
aeruginosa) 		5 / 11 VAL A  36
PHE A 140
SER A 135
SER A 134
THR A  38
 None
 1.29A 4mmaA-2f96A:
undetectable		 4mmaA-2f96A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 2f96 RIBONUCLEASE T
(Pseudomonas
aeruginosa) 		4 / 4 ALA A 195
VAL A  34
GLY A 131
THR A 202
 None
 0.96A 4ubeA-2f96A:
undetectable		 4ubeA-2f96A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 2f96 RIBONUCLEASE T
(Pseudomonas
aeruginosa) 		4 / 4 THR A 199
VAL A  33
PRO A  66
THR A  54
 None
 1.41A 5mthA-2f96A:
0.0
5mthH-2f96A:
0.0		 5mthA-2f96A:
20.70
5mthH-2f96A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 2f96 RIBONUCLEASE T
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 137
GLY A 131
ASP A  35
ASN A 133
 MG  A2001 ( 4.1A)
None
MG  A2001 (-2.5A)
None
 0.79A 5nnwD-2f96A:
undetectable		 5nnwD-2f96A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 2f96 RIBONUCLEASE T
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 137
GLY A 131
ASP A  35
ASN A 133
 MG  A2001 ( 4.1A)
None
MG  A2001 (-2.5A)
None
 0.81A 5no9D-2f96A:
undetectable		 5no9D-2f96A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 2f96 RIBONUCLEASE T
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  53
LEU A 129
ILE A 128
VAL A  56
PHE A 206
 None
 1.45A 5vlmE-2f96A:
undetectable		 5vlmE-2f96A:
22.73