SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f9g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 269
ILE A 239
ILE A 283
ILE A 222
ILE A 238
 None
 0.94A 1hshB-2f9gA:
undetectable		 1hshB-2f9gA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 187
HIS A 101
LYS A 139
 None
 1.48A 1l7xA-2f9gA:
0.0		 1l7xA-2f9gA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		7 / 12 LEU A  19
ALA A  40
LYS A  42
GLU A  59
LEU A  95
MET A  96
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
ADP  A 500 ( 4.9A)
None
ADP  A 500 (-4.3A)
 0.49A 1m17A-2f9gA:
23.1		 1m17A-2f9gA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  19
ILE A  91
MET A  96
ARG A 136
 ADP  A 500 (-4.3A)
None
None
None
 1.00A 1opjB-2f9gA:
13.9		 1opjB-2f9gA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  19
LYS A  42
ILE A  91
ARG A 136
 ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
None
 0.96A 1opjB-2f9gA:
13.9		 1opjB-2f9gA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 119
TYR A 116
GLU A 318
PRO A 315
 None
 1.30A 1q13A-2f9gA:
undetectable		 1q13A-2f9gA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  19
VAL A  27
LYS A  42
LEU A  95
MET A  96
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
ADP  A 500 ( 4.9A)
None
 0.70A 1xkkA-2f9gA:
21.2		 1xkkA-2f9gA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  19
ALA A  40
ILE A  72
ASP A  99
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 (-3.5A)
ADP  A 500 (-4.3A)
 1.01A 1yi4A-2f9gA:
15.9		 1yi4A-2f9gA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		7 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
ASP A 137
LYS A 139
ASN A 142
 ADP  A 500 (-4.3A)
ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
None
MG  A 600 ( 2.7A)
 0.76A 2fumA-2f9gA:
17.0		 2fumA-2f9gA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		7 / 12 LEU A  19
VAL A  27
ALA A  40
ASP A 137
LYS A 139
ASN A 142
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
None
MG  A 600 ( 2.7A)
ADP  A 500 ( 2.9A)
 0.82A 2fumA-2f9gA:
17.0		 2fumA-2f9gA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 142
ILE A 145
MET A  96
 MG  A 600 ( 2.7A)
None
None
 0.84A 2h42C-2f9gA:
undetectable		 2h42C-2f9gA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		8 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LYS A  42
GLU A  59
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.82A 2ityA-2f9gA:
17.3		 2ityA-2f9gA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		7 / 12 LEU A  19
GLY A  20
VAL A  27
LYS A  42
GLU A  59
LEU A  63
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
None
ADP  A 500 (-4.3A)
 0.47A 2ivuA-2f9gA:
11.7		 2ivuA-2f9gA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 298
GLY A 210
ILE A 212
LEU A 304
 None
 0.68A 2o4nB-2f9gA:
undetectable		 2o4nB-2f9gA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  51
PRO A  50
LEU A  54
ARG A 160
 None
 1.46A 2qd2A-2f9gA:
undetectable		 2qd2A-2f9gA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 9 LEU A  19
VAL A  27
ALA A  40
MET A  96
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.75A 2xp2A-2f9gA:
22.6		 2xp2A-2f9gA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 12 VAL A  27
ALA A  40
ILE A  72
LEU A  95
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 ( 4.9A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.67A 2y7jA-2f9gA:
20.6		 2y7jA-2f9gA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 12 VAL A  27
ALA A  40
ILE A  72
LEU A  95
MET A  96
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 ( 4.9A)
None
ADP  A 500 (-4.3A)
 0.31A 2y7jA-2f9gA:
20.6		 2y7jA-2f9gA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 10 VAL A  27
ALA A  40
ILE A  72
LEU A  95
MET A  96
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 ( 4.9A)
None
ADP  A 500 (-4.3A)
 0.27A 2y7jB-2f9gA:
20.6		 2y7jB-2f9gA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 10 VAL A  27
ALA A  40
ILE A  72
LEU A  95
MET A  96
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 ( 4.9A)
None
ADP  A 500 (-4.3A)
 0.26A 2y7jC-2f9gA:
20.1		 2y7jC-2f9gA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 10 VAL A  27
ALA A  40
ILE A  72
LEU A  95
MET A  96
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 ( 4.9A)
None
ADP  A 500 (-4.3A)
 0.25A 2y7jD-2f9gA:
20.6		 2y7jD-2f9gA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 8 LEU A  19
ALA A  40
MET A  96
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.64A 2yfxA-2f9gA:
13.9		 2yfxA-2f9gA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 251
GLU A 192
VAL A 193
ARG A 297
PHE A 292
 None
 1.37A 2ziaB-2f9gA:
undetectable		 2ziaB-2f9gA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		7 / 12 LEU A  19
ALA A  40
LYS A  42
GLU A  59
ILE A  91
MET A  96
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
None
ADP  A 500 (-4.3A)
 0.69A 2zvaA-2f9gA:
16.0		 2zvaA-2f9gA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 10 LEU A  19
ALA A  40
LYS A  42
LEU A  95
MET A  96
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
ADP  A 500 ( 4.9A)
None
ADP  A 500 (-4.3A)
 0.60A 3aoxA-2f9gA:
21.9		 3aoxA-2f9gA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  19
VAL A  27
ILE A  91
LEU A 144
VAL A 153
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
None
ADP  A 500 (-4.3A)
None
 0.84A 3cs9B-2f9gA:
14.9		 3cs9B-2f9gA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  19
VAL A  27
ILE A  91
MET A  96
VAL A 153
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
None
None
None
 0.91A 3cs9C-2f9gA:
14.9		 3cs9C-2f9gA:
25.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  40
LEU A  63
ILE A  72
LEU A  95
ASP A 155
 ADP  A 500 ( 3.7A)
None
None
ADP  A 500 ( 4.9A)
ADP  A 500 ( 2.9A)
 0.81A 3hecA-2f9gA:
23.7		 3hecA-2f9gA:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 12 ALA A  40
LYS A  42
GLU A  59
LEU A  63
ILE A  72
LEU A  95
 ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
None
ADP  A 500 ( 4.9A)
 0.52A 3hecA-2f9gA:
23.7		 3hecA-2f9gA:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 12 VAL A  27
ALA A  40
LYS A  42
GLU A  59
LEU A  63
MET A  96
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
None
 1.47A 3hegA-2f9gA:
36.0		 3hegA-2f9gA:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  27
ALA A  40
LYS A  42
LEU A  63
ILE A  72
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
 0.74A 3hegA-2f9gA:
36.0		 3hegA-2f9gA:
45.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  19
ILE A  91
MET A  96
ARG A 136
 ADP  A 500 (-4.3A)
None
None
None
 0.69A 3ik3A-2f9gA:
14.2		 3ik3A-2f9gA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  19
LYS A  42
ILE A  91
ARG A 136
 ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
None
 0.85A 3ik3A-2f9gA:
14.2		 3ik3A-2f9gA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  19
ILE A  91
MET A  96
ARG A 136
 ADP  A 500 (-4.3A)
None
None
None
 0.68A 3ik3B-2f9gA:
21.4		 3ik3B-2f9gA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  19
LYS A  42
ILE A  91
ARG A 136
 ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
None
 0.79A 3ik3B-2f9gA:
21.4		 3ik3B-2f9gA:
25.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 8 ALA A  40
LYS A  42
GLU A  59
LEU A  95
MET A  96
 ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
ADP  A 500 ( 4.9A)
None
 0.60A 3lfaA-2f9gA:
35.0		 3lfaA-2f9gA:
44.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 251
GLU A 192
ARG A 297
PHE A 292
LEU A 248
 None
 1.08A 3mjrA-2f9gA:
undetectable		 3mjrA-2f9gA:
23.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 12 GLY A  20
VAL A  27
ALA A  40
LYS A  42
ILE A  72
LEU A 144
 ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
ADP  A 500 (-4.3A)
 1.00A 3ohtA-2f9gA:
8.3		 3ohtA-2f9gA:
41.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 12 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  63
ILE A  72
 ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
 0.69A 3ohtA-2f9gA:
8.3		 3ohtA-2f9gA:
41.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_1
(P38A)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 12 GLY A  20
VAL A  27
ALA A  40
LYS A  42
ILE A  72
LEU A 144
 ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
ADP  A 500 (-4.3A)
 1.00A 3ohtB-2f9gA:
28.7		 3ohtB-2f9gA:
41.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_1
(P38A)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 12 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  63
ILE A  72
 ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
 0.68A 3ohtB-2f9gA:
28.7		 3ohtB-2f9gA:
41.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 9 LEU A  19
ILE A  91
MET A  96
ARG A 136
LEU A 144
VAL A 153
 ADP  A 500 (-4.3A)
None
None
None
ADP  A 500 (-4.3A)
None
 0.81A 3oxzA-2f9gA:
14.4		 3oxzA-2f9gA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  19
MET A  96
ARG A  58
LEU A 144
VAL A 153
 ADP  A 500 (-4.3A)
None
None
ADP  A 500 (-4.3A)
None
 1.00A 3oxzA-2f9gA:
14.4		 3oxzA-2f9gA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 8 ASP A  48
PRO A  50
PRO A  46
GLU A  45
 None
 1.05A 3oyaA-2f9gA:
undetectable		 3oyaA-2f9gA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 115
TYR A 308
PHE A 217
LEU A 216
 None
 1.36A 3tgvB-2f9gA:
undetectable		 3tgvB-2f9gA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  27
LYS A  42
ILE A  72
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
ADP  A 500 ( 2.9A)
 0.75A 3warA-2f9gA:
28.6		 3warA-2f9gA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		7 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  59
LEU A  63
HIS A 135
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
None
 0.68A 3wzeA-2f9gA:
6.4		 3wzeA-2f9gA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		7 / 12 LEU A  19
VAL A  27
LYS A  42
GLU A  59
LEU A  63
LEU A 128
HIS A 135
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
None
None
None
 0.69A 3wzeA-2f9gA:
6.4		 3wzeA-2f9gA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 12 ALA A  40
LEU A  95
MET A  96
ASP A  99
LEU A 144
ASP A 155
 ADP  A 500 ( 3.7A)
ADP  A 500 ( 4.9A)
None
ADP  A 500 (-3.5A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.62A 3zbfA-2f9gA:
17.0		 3zbfA-2f9gA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		7 / 12 ALA A  40
LYS A  42
GLU A  59
ILE A  72
LEU A 128
HIS A 135
LEU A 144
 ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
None
None
ADP  A 500 (-4.3A)
 0.85A 3zosB-2f9gA:
21.4		 3zosB-2f9gA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  59
LEU A  63
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
 0.53A 4agcA-2f9gA:
3.5		 4agcA-2f9gA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 9 LEU A  19
VAL A  27
ALA A  40
MET A  96
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.72A 4anqA-2f9gA:
22.3		 4anqA-2f9gA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 9 LEU A  19
VAL A  27
ALA A  40
MET A  96
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.72A 4ansA-2f9gA:
22.2		 4ansA-2f9gA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		7 / 12 ALA A  40
LYS A  42
GLU A  59
LEU A  63
ILE A  91
HIS A 135
LEU A 144
 ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
None
None
ADP  A 500 (-4.3A)
 0.77A 4c8bA-2f9gA:
13.7		 4c8bA-2f9gA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 10 LEU A  19
GLY A  20
GLY A  22
VAL A  27
ALA A  40
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 4.1A)
ADP  A 500 ( 4.6A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-4.3A)
 0.28A 4ckjA-2f9gA:
19.9		 4ckjA-2f9gA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		9 / 12 VAL A  27
ALA A  40
ILE A  72
ASP A  99
ASP A 137
LYS A 139
ASN A 142
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 (-3.5A)
None
None
MG  A 600 ( 2.7A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.92A 4i41A-2f9gA:
24.1		 4i41A-2f9gA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 139
PRO A 140
SER A 141
 None
None
ADP  A 500 (-4.4A)
 0.41A 4k50I-2f9gA:
undetectable		 4k50I-2f9gA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 7 VAL A  27
ALA A  40
MET A  96
ASP A  99
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 (-3.5A)
ADP  A 500 (-4.3A)
 0.89A 4l9iA-2f9gA:
7.5		 4l9iA-2f9gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 8 GLY A  22
VAL A  27
ALA A  40
LYS A  42
ASP A  99
 ADP  A 500 ( 4.6A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
ADP  A 500 (-3.5A)
 1.00A 4l9iB-2f9gA:
25.0		 4l9iB-2f9gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 8 GLY A  25
VAL A  27
ALA A  40
MET A  96
LEU A 144
 ADP  A 500 (-3.8A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 (-4.3A)
 1.15A 4l9iB-2f9gA:
25.0		 4l9iB-2f9gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 8 VAL A  27
ALA A  40
LYS A  42
MET A  96
ASP A  99
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
ADP  A 500 (-3.5A)
ADP  A 500 (-4.3A)
 0.85A 4l9iB-2f9gA:
25.0		 4l9iB-2f9gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		7 / 12 LEU A  19
GLY A  25
VAL A  27
ALA A  40
LYS A  42
LEU A  95
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 (-3.8A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
ADP  A 500 ( 4.9A)
ADP  A 500 ( 2.9A)
 1.10A 4mkcA-2f9gA:
22.4		 4mkcA-2f9gA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		8 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
LEU A  95
ASP A  99
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
ADP  A 500 ( 4.9A)
ADP  A 500 (-3.5A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.76A 4mkcA-2f9gA:
22.4		 4mkcA-2f9gA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		7 / 11 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LYS A  42
ASN A 142
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
MG  A 600 ( 2.7A)
ADP  A 500 (-4.3A)
 0.83A 4o0sA-2f9gA:
27.1		 4o0sA-2f9gA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 6 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-4.3A)
 0.61A 4o0wA-2f9gA:
20.1		 4o0wA-2f9gA:
27.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 7 GLY A  20
ALA A  40
ASP A  99
ASN A 142
LEU A 144
 ADP  A 500 ( 4.1A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-3.5A)
MG  A 600 ( 2.7A)
ADP  A 500 (-4.3A)
 0.81A 4ogrE-2f9gA:
30.0		 4ogrE-2f9gA:
33.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 8 LEU A  19
VAL A  27
ILE A  72
HIS A 135
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
None
None
ADP  A 500 (-4.3A)
 0.58A 4qrcA-2f9gA:
22.3		 4qrcA-2f9gA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 12 ALA A  40
LYS A  42
LEU A  63
HIS A 135
LEU A 144
CYH A 154
 ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.8A)
 0.64A 4u0iA-2f9gA:
21.6		 4u0iA-2f9gA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		8 / 11 LEU A  19
GLY A  22
VAL A  27
ALA A  40
MET A  96
ASN A 142
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 ( 4.6A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
MG  A 600 ( 2.7A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.65A 4u5jA-2f9gA:
15.7		 4u5jA-2f9gA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 9 LEU A  19
VAL A  27
LYS A  42
ILE A  72
ARG A 136
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
None
ADP  A 500 (-4.3A)
 0.82A 4v01B-2f9gA:
14.3		 4v01B-2f9gA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  19
ALA A  40
MET A  96
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 (-4.3A)
 0.44A 4wboC-2f9gA:
25.3		 4wboC-2f9gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 12 LEU A  19
ALA A  40
LYS A  42
GLU A  59
LEU A  95
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
ADP  A 500 ( 4.9A)
ADP  A 500 (-4.3A)
 0.46A 4wkqA-2f9gA:
23.0		 4wkqA-2f9gA:
24.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 6 ALA A  40
GLN A  93
LEU A  95
MET A  96
LEU A 144
 ADP  A 500 ( 3.7A)
ADP  A 500 (-3.8A)
ADP  A 500 ( 4.9A)
None
ADP  A 500 (-4.3A)
 0.66A 4xoyA-2f9gA:
15.1		 4xoyA-2f9gA:
50.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 6 ALA A  40
GLN A  93
LEU A  95
MET A  96
LEU A 144
 ADP  A 500 ( 3.7A)
ADP  A 500 (-3.8A)
ADP  A 500 ( 4.9A)
None
ADP  A 500 (-4.3A)
 0.57A 4xp3A-2f9gA:
41.0		 4xp3A-2f9gA:
50.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 8 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LEU A  95
MET A  96
 ADP  A 500 (-4.3A)
ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 ( 4.9A)
None
 0.55A 4zauA-2f9gA:
17.9		 4zauA-2f9gA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 9 LEU A  19
VAL A  27
ALA A  40
MET A  96
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.76A 5aaaA-2f9gA:
22.6		 5aaaA-2f9gA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		7 / 10 LEU A  19
VAL A  27
ALA A  40
LYS A  42
MET A  96
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.92A 5aabA-2f9gA:
22.4		 5aabA-2f9gA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  27
ALA A  40
LYS A  42
LEU A  63
PHE A 156
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
 0.78A 5cswA-2f9gA:
21.5		 5cswA-2f9gA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  27
ALA A  40
LYS A  42
LEU A  63
PHE A 156
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
 0.83A 5cswB-2f9gA:
21.5		 5cswB-2f9gA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  19
VAL A  27
ALA A  40
LEU A  95
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 ( 4.9A)
ADP  A 500 (-4.3A)
 0.45A 5h2uA-2f9gA:
16.5		 5h2uA-2f9gA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 12 LEU A  19
VAL A  27
ALA A  40
ILE A  91
LEU A  95
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 ( 4.9A)
ADP  A 500 (-4.3A)
 0.63A 5h2uB-2f9gA:
16.6		 5h2uB-2f9gA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		3 / 3 ILE A  72
ILE A  91
MET A  96
 None
 0.53A 5i9yA-2f9gA:
16.9		 5i9yA-2f9gA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  20
GLY A  22
VAL A  27
LYS A  42
 ADP  A 500 ( 4.1A)
ADP  A 500 ( 4.6A)
ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
 0.32A 5izjA-2f9gA:
16.2		 5izjA-2f9gA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 7 GLY A  20
GLY A  22
VAL A  27
LYS A  42
ASP A 155
 ADP  A 500 ( 4.1A)
ADP  A 500 ( 4.6A)
ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
ADP  A 500 ( 2.9A)
 0.66A 5j5xA-2f9gA:
26.0		 5j5xA-2f9gA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 9 GLY A  20
VAL A  27
ALA A  40
ILE A  72
MET A  96
 ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
None
 0.63A 5lw1B-2f9gA:
21.7		 5lw1B-2f9gA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 10 GLY A  20
VAL A  27
ALA A  40
ILE A  72
LEU A  95
MET A  96
 ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 ( 4.9A)
None
 0.68A 5lw1E-2f9gA:
24.1		 5lw1E-2f9gA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 9 GLY A  20
VAL A  27
ALA A  40
LEU A  95
MET A  96
 ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 ( 4.9A)
None
 0.54A 5lw1H-2f9gA:
24.7		 5lw1H-2f9gA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  19
VAL A  27
LYS A  42
GLU A  59
ILE A  91
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
None
 0.58A 5mo4A-2f9gA:
18.9		 5mo4A-2f9gA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 267
GLY A 240
TYR A 266
LEU A 271
 None
 0.89A 5x80A-2f9gA:
undetectable
5x80B-2f9gA:
undetectable		 5x80A-2f9gA:
18.80
5x80B-2f9gA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		6 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
ADP  A 500 (-4.3A)
 0.58A 5yu9A-2f9gA:
21.1		 5yu9A-2f9gA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		4 / 7 VAL A  27
LYS A  42
ILE A  72
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
ADP  A 500 ( 2.9A)
 0.57A 5ywmX-2f9gA:
22.8		 5ywmX-2f9gA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3
(Saccharomyces
cerevisiae) 		7 / 12 VAL A  27
ALA A  40
LYS A  42
GLU A  59
ILE A  91
MET A  96
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
None
ADP  A 500 (-4.3A)
 0.81A 6fnmA-2f9gA:
16.7		 6fnmA-2f9gA:
27.61