SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f9i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		4 / 6 ALA B  86
ILE B 175
PRO B  88
GLU B 172
 None
 1.14A 1oniB-2f9iB:
undetectable
1oniC-2f9iB:
undetectable		 1oniB-2f9iB:
17.56
1oniC-2f9iB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		4 / 7 ILE B 175
PRO B  88
GLU B 172
ALA B  86
 None
 1.08A 1oniD-2f9iB:
undetectable
1oniE-2f9iB:
undetectable		 1oniD-2f9iB:
17.56
1oniE-2f9iB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		4 / 5 ILE B  67
LEU B  61
ALA B  69
GLU B  68
 None
 1.27A 1xvaA-2f9iB:
undetectable
1xvaB-2f9iB:
undetectable		 1xvaA-2f9iB:
20.94
1xvaB-2f9iB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		4 / 6 ALA B  69
GLU B  68
ILE B  67
LEU B  61
 None
 0.94A 1xvaA-2f9iB:
undetectable
1xvaB-2f9iB:
undetectable		 1xvaA-2f9iB:
20.94
1xvaB-2f9iB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		5 / 12 LEU B 161
PHE B 213
ALA B 110
ILE B 141
ALA B 164
 None
 0.99A 2bxpA-2f9iB:
undetectable		 2bxpA-2f9iB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		5 / 12 ASP B 129
ALA B  63
THR B  62
GLU B  78
ARG B 133
 None
 0.98A 2gluA-2f9iB:
undetectable		 2gluA-2f9iB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		5 / 12 THR B 202
THR B 205
LEU B 161
ILE B  70
MET B 269
 None
 1.31A 3gwxA-2f9iB:
undetectable		 3gwxA-2f9iB:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		4 / 6 LEU B 195
GLN B 281
LEU B 196
GLU B 282
 None
 1.13A 3h5gB-2f9iB:
undetectable
3h5gC-2f9iB:
undetectable		 3h5gB-2f9iB:
9.27
3h5gC-2f9iB:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		5 / 12 LEU B 221
TYR B 200
ILE B  70
ILE B 160
ILE B 279
 None
 1.01A 3uj6A-2f9iB:
undetectable		 3uj6A-2f9iB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		5 / 12 LEU B 221
TYR B 200
ILE B  70
ILE B 160
ILE B 279
 None
 1.03A 3uj7A-2f9iB:
undetectable		 3uj7A-2f9iB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		5 / 12 LEU B 221
TYR B 200
ILE B  70
ILE B 219
ILE B 160
 None
 1.11A 3uj7A-2f9iB:
undetectable		 3uj7A-2f9iB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		4 / 7 VAL B 111
GLY B 142
THR B 183
PHE B 159
 None
 0.82A 4ejjB-2f9iB:
undetectable		 4ejjB-2f9iB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		5 / 11 ILE B 148
PHE B 159
SER B 212
ILE B 145
THR B 153
 None
 1.49A 4p68A-2f9iB:
undetectable		 4p68A-2f9iB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		6 / 12 VAL B 127
LEU B 273
ILE B  70
GLU B  78
VAL B 264
LEU B 221
 None
 1.42A 4y0sA-2f9iB:
undetectable		 4y0sA-2f9iB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		5 / 12 GLY B 217
SER B 199
ASP B 218
GLY B 181
SER B 184
 None
 1.14A 5hikA-2f9iB:
undetectable		 5hikA-2f9iB:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		5 / 10 VAL B 111
ALA B 126
PHE B 159
THR B 153
LEU B 187
 None
 1.36A 5mm4B-2f9iB:
2.5		 5mm4B-2f9iB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		4 / 6 PRO B 158
LEU B 157
PHE B 159
LEU B 196
 None
 1.09A 5tl8A-2f9iB:
undetectable		 5tl8A-2f9iB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA
(Staphylococcus
aureus) 		3 / 3 TYR B  94
PRO B  88
LEU B  89
 None
 0.93A 6beoA-2f9iB:
undetectable		 6beoA-2f9iB:
4.76