SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2f9r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		4 / 6 PHE A 165
LEU A  92
VAL A 109
VAL A 142
 None
 1.06A 1e7aB-2f9rA:
undetectable		 1e7aB-2f9rA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		4 / 6 LEU A  92
LEU A  97
LEU A  67
LEU A  70
 None
 0.91A 1errA-2f9rA:
undetectable		 1errA-2f9rA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		4 / 6 LEU A 242
GLY A 245
LYS A 269
TYR A 270
 None
 0.95A 1gtiC-2f9rA:
undetectable		 1gtiC-2f9rA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		4 / 7 LEU A 242
GLY A 245
LYS A 269
TYR A 270
 None
 0.95A 1gtiD-2f9rA:
undetectable		 1gtiD-2f9rA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		4 / 7 LEU A 242
GLY A 245
LYS A 269
TYR A 270
 None
 0.95A 1gtiE-2f9rA:
undetectable		 1gtiE-2f9rA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		4 / 5 LEU A 242
GLY A 245
LYS A 269
TYR A 270
 None
 0.95A 1gtiF-2f9rA:
undetectable		 1gtiF-2f9rA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		5 / 12 ILE A  20
PRO A  21
ASP A  25
ALA A  33
THR A  69
 None
 1.25A 1kijB-2f9rA:
undetectable		 1kijB-2f9rA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		5 / 12 THR A  74
PHE A  85
LEU A  90
VAL A  35
PHE A  63
 None
 1.27A 1q23C-2f9rA:
undetectable		 1q23C-2f9rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		5 / 11 THR A  74
PHE A  85
LEU A  90
VAL A  35
PHE A  63
 None
 1.22A 1q23L-2f9rA:
undetectable		 1q23L-2f9rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		4 / 7 THR A 199
GLY A 167
THR A 179
ASP A 196
 None
 0.94A 2a1mA-2f9rA:
undetectable		 2a1mA-2f9rA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		3 / 3 ASP A 268
TYR A 270
LYS A 239
 None
 0.87A 2othA-2f9rA:
undetectable		 2othA-2f9rA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		5 / 7 ASP A 247
VAL A 246
ALA A 241
PHE A 283
PRO A   6
 None
 1.32A 2q6oA-2f9rA:
undetectable		 2q6oA-2f9rA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		4 / 6 ASP A 247
VAL A 246
PHE A 283
PRO A   6
 None
 1.25A 2q6oB-2f9rA:
undetectable		 2q6oB-2f9rA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		4 / 6 THR A  45
VAL A  35
LEU A  67
GLU A 112
 None
 1.20A 3b6rB-2f9rA:
undetectable		 3b6rB-2f9rA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAM_A_LLLA500_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		5 / 12 SER A 231
ASP A 196
ASP A  52
ASP A  34
TYR A 169
 None
None
None
MG  A 601 (-2.4A)
None
 1.30A 3hamA-2f9rA:
0.0		 3hamA-2f9rA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		5 / 10 THR A  74
PHE A  85
LEU A  90
VAL A  35
PHE A  63
 None
 1.25A 3u9fE-2f9rA:
undetectable		 3u9fE-2f9rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		5 / 9 THR A  74
PHE A  85
LEU A  90
VAL A  35
PHE A  63
 None
 1.20A 3u9fP-2f9rA:
undetectable		 3u9fP-2f9rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		5 / 12 THR A  74
PHE A  85
LEU A  90
VAL A  35
PHE A  63
 None
 1.20A 3u9fP-2f9rA:
undetectable
3u9fS-2f9rA:
undetectable		 3u9fP-2f9rA:
22.22
3u9fS-2f9rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		4 / 6 ALA A 273
GLY A 248
ILE A  86
VAL A  89
 None
 0.79A 4r21A-2f9rA:
undetectable		 4r21A-2f9rA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		5 / 9 ILE A 249
ILE A   7
ILE A 258
PRO A 254
LEU A 261
 None
 0.98A 5mvmA-2f9rA:
undetectable
5mvmE-2f9rA:
undetectable		 5mvmA-2f9rA:
14.74
5mvmE-2f9rA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2f9r SPHINGOMYELINASE D 1
(Loxosceles
laeta) 		5 / 10 ILE A 258
PRO A 254
LEU A 261
ILE A 249
ILE A   7
 None
 1.00A 5mvmD-2f9rA:
undetectable
5mvmE-2f9rA:
undetectable		 5mvmD-2f9rA:
14.74
5mvmE-2f9rA:
14.74