SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fa0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 12 VAL A 324
GLY A 325
MET A 327
VAL A 388
PHE A  14
 None
 1.23A 1a27A-2fa0A:
undetectable		 1a27A-2fa0A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		4 / 4 ILE A 169
MET A  10
VAL A 245
GLY A   6
 None
 1.12A 1e06B-2fa0A:
undetectable		 1e06B-2fa0A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 11 GLU A 178
SER A 367
PHE A 244
PHE A 228
PHE A 236
 None
 1.24A 1w76A-2fa0A:
undetectable		 1w76A-2fa0A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		3 / 3 HIS A 341
ASP A  11
ASN A  59
 None
 0.73A 1wg8B-2fa0A:
undetectable		 1wg8B-2fa0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		3 / 3 VAL A  61
VAL A 143
ASP A 107
 None
 0.62A 2fumD-2fa0A:
undetectable		 2fumD-2fa0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		4 / 7 LYS A 234
ASP A 265
PHE A 228
ARG A 351
 None
 1.16A 2pk4A-2fa0A:
undetectable		 2pk4A-2fa0A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 12 ILE A 169
GLY A 170
VAL A   5
ASN A   4
PRO A 174
 None
 1.01A 3jb3A-2fa0A:
undetectable		 3jb3A-2fa0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		4 / 8 LEU A  64
SER A  63
LEU A  78
ILE A  70
 None
 0.89A 3ln1A-2fa0A:
undetectable		 3ln1A-2fa0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		4 / 7 LEU A  64
SER A  63
LEU A  78
ILE A  70
 None
 0.90A 3ln1B-2fa0A:
undetectable		 3ln1B-2fa0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 10 LEU A  65
ALA A 166
ILE A  12
ILE A 169
LEU A  64
 None
 0.92A 3ogpA-2fa0A:
undetectable		 3ogpA-2fa0A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 10 LEU A  65
ALA A 166
ILE A  12
ILE A 169
LEU A  64
 None
 0.87A 3ogqA-2fa0A:
undetectable		 3ogqA-2fa0A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		4 / 5 ASN A 115
ALA A 116
TYR A 357
ALA A 363
 None
HMG  A 500 (-2.5A)
HMG  A 500 (-4.4A)
None
 1.33A 3twpD-2fa0A:
undetectable		 3twpD-2fa0A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		3 / 3 GLU A 200
TYR A 414
SER A 199
 None
 0.97A 4at0A-2fa0A:
undetectable		 4at0A-2fa0A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		4 / 8 ASN A 326
LEU A  39
VAL A 254
GLY A 206
 HMG  A 500 (-3.2A)
None
None
HMG  A 500 (-3.7A)
 0.87A 4r3aA-2fa0A:
0.7		 4r3aA-2fa0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 12 LEU A 142
LEU A  78
ILE A 144
ILE A  92
LEU A  65
 None
 0.99A 4y0sA-2fa0A:
undetectable		 4y0sA-2fa0A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 12 LEU A 368
LEU A 370
ILE A 175
ILE A 382
VAL A 340
 None
 0.99A 4y0sA-2fa0A:
undetectable		 4y0sA-2fa0A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 12 GLY A 161
TYR A  13
SER A 248
ALA A 149
TYR A 151
 None
None
None
None
HMG  A 500 (-4.1A)
 1.37A 4ymgA-2fa0A:
undetectable		 4ymgA-2fa0A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 12 GLY A 161
TYR A  13
SER A 248
ALA A 149
TYR A 151
 None
None
None
None
HMG  A 500 (-4.1A)
 1.36A 4ymgB-2fa0A:
undetectable		 4ymgB-2fa0A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 12 TYR A  35
THR A  36
LEU A  44
ALA A  23
THR A 406
 None
 1.32A 5ewjC-2fa0A:
undetectable
5ewjD-2fa0A:
undetectable		 5ewjC-2fa0A:
23.60
5ewjD-2fa0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		3 / 3 LEU A 125
TYR A 118
SER A 184
 None
 0.61A 5iktA-2fa0A:
undetectable		 5iktA-2fa0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 9 THR A 329
ALA A 164
ALA A 166
ALA A  60
GLY A  81
 None
 1.01A 5l5zK-2fa0A:
undetectable
5l5zL-2fa0A:
undetectable		 5l5zK-2fa0A:
19.33
5l5zL-2fa0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 9 THR A 329
ALA A 164
ALA A 166
ALA A  60
GLY A  81
 None
 1.01A 5l5zY-2fa0A:
undetectable
5l5zZ-2fa0A:
undetectable		 5l5zY-2fa0A:
19.33
5l5zZ-2fa0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 12 PHE A 366
PHE A 336
ALA A 337
ILE A 382
ALA A   9
 None
 0.96A 5vceA-2fa0A:
undetectable		 5vceA-2fa0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		4 / 6 GLY A 141
GLY A 170
PRO A 171
GLY A   6
 None
 0.66A 6ag0C-2fa0A:
undetectable		 6ag0C-2fa0A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		4 / 8 GLY A 141
LEU A 142
VAL A 108
LEU A  65
 None
 0.85A 6czmD-2fa0A:
0.8
6czmF-2fa0A:
0.6		 6czmD-2fa0A:
23.16
6czmF-2fa0A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 2fa0 HMG-COA SYNTHASE
(Brassica
juncea) 		5 / 12 GLY A 161
GLY A 160
GLY A  81
HIS A 247
PRO A 202
 None
None
None
HMG  A 500 (-3.3A)
None
 1.06A 6gngB-2fa0A:
undetectable		 6gngB-2fa0A:
23.06