SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2faf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 9 ALA A 449
ASP A 448
GLY A 288
VAL A 555
ILE A 559
 None
 1.16A 1hpvB-2fafA:
undetectable		 1hpvB-2fafA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 11 GLU A  70
SER A  35
SER A  37
LEU A  63
LEU A  41
 None
 1.46A 1hwkB-2fafA:
undetectable		 1hwkB-2fafA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 11 GLU A  70
SER A  35
SER A  37
LEU A  63
LEU A  41
 None
 1.46A 1hwkA-2fafA:
undetectable		 1hwkA-2fafA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 11 GLU A  70
SER A  35
SER A  37
LEU A  63
LEU A  41
 None
 1.46A 1hwkD-2fafA:
undetectable		 1hwkD-2fafA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 11 GLU A  70
SER A  35
SER A  37
LEU A  63
LEU A  41
 None
 1.45A 1hwkC-2fafA:
0.0		 1hwkC-2fafA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		4 / 4 GLY A 308
ASP A 329
GLY A 350
THR A 374
 1PE  A1262 ( 3.9A)
None
None
None
 1.05A 1hxbB-2fafA:
undetectable		 1hxbB-2fafA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 11 SER A 258
GLY A 253
TYR A 185
GLY A 256
HIS A 420
 None
None
None
1PE  A1262 (-3.3A)
None
 1.14A 1iolA-2fafA:
undetectable		 1iolA-2fafA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 11 LEU A 513
TYR A 615
TYR A 614
PRO A 503
TYR A 512
 None
 1.44A 1klmA-2fafA:
undetectable		 1klmA-2fafA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		4 / 4 HIS A 471
ALA A 466
PHE A 531
GLY A 575
 None
 1.42A 1mj2B-2fafA:
undetectable		 1mj2B-2fafA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		4 / 4 HIS A 471
ALA A 466
PHE A 531
GLY A 575
 None
 1.40A 1mjoB-2fafA:
undetectable		 1mjoB-2fafA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		4 / 4 HIS A 471
ALA A 466
PHE A 531
GLY A 575
 None
 1.34A 1mjoA-2fafA:
undetectable		 1mjoA-2fafA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		4 / 4 HIS A 471
ALA A 466
PHE A 531
GLY A 575
 None
 1.42A 1mjoD-2fafA:
undetectable		 1mjoD-2fafA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 12 LEU A 267
LEU A 260
GLN A 179
MET A 190
MET A 166
 None
 1.34A 1sqnA-2fafA:
undetectable		 1sqnA-2fafA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 12 LEU A  63
GLY A  66
GLY A 197
ARG A 203
PRO A  42
 None
 0.98A 1y4lA-2fafA:
undetectable		 1y4lA-2fafA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		3 / 3 ALA A 366
THR A 358
PHE A 351
 None
 0.61A 2c6nB-2fafA:
undetectable		 2c6nB-2fafA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 9 ALA A 449
ASP A 448
GLY A 288
VAL A 555
ILE A 559
 None
 1.01A 2q5kA-2fafA:
undetectable		 2q5kA-2fafA:
11.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		6 / 8 ARG A 105
LYS A 262
LYS A 263
HIS A 283
ASP A 330
ARG A 424
 1PE  A1262 (-3.7A)
1PE  A1262 (-4.3A)
MN  A1701 ( 1.9A)
MN  A1701 (-3.2A)
MN  A1701 (-2.3A)
1PE  A1262 (-3.0A)
 0.67A 2rk8A-2fafA:
53.8		 2rk8A-2fafA:
63.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		6 / 7 ARG A 105
LYS A 262
LYS A 263
HIS A 283
ASP A 330
ARG A 424
 1PE  A1262 (-3.7A)
1PE  A1262 (-4.3A)
MN  A1701 ( 1.9A)
MN  A1701 (-3.2A)
MN  A1701 (-2.3A)
1PE  A1262 (-3.0A)
 0.63A 2rk8B-2fafA:
55.1		 2rk8B-2fafA:
63.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 12 GLY A 561
GLY A 565
ILE A 559
ALA A 557
ASP A 448
 None
 1.25A 2vdvE-2fafA:
undetectable		 2vdvE-2fafA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 11 GLY A 561
GLY A 565
ILE A 559
ALA A 557
ASP A 448
 None
 1.26A 2vdvF-2fafA:
undetectable		 2vdvF-2fafA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 12 LEU A 267
LEU A 260
GLN A 179
MET A 193
MET A 190
 None
 1.42A 2w8yB-2fafA:
undetectable		 2w8yB-2fafA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		3 / 3 SER A 249
GLY A 251
GLY A 253
 None
 0.51A 3bogA-2fafA:
undetectable
3bogC-2fafA:
undetectable		 3bogA-2fafA:
undetectable
3bogC-2fafA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		4 / 8 HIS A 532
GLY A 454
ASN A 534
ARG A 456
 None
 1.24A 3ccfA-2fafA:
undetectable		 3ccfA-2fafA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 9 ALA A 449
ASP A 448
GLY A 288
VAL A 555
ILE A 559
 None
 1.21A 3em4B-2fafA:
undetectable		 3em4B-2fafA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 11 ALA A  96
GLY A 253
ILE A 375
VAL A 186
SER A 189
 None
 1.24A 3gyqB-2fafA:
undetectable		 3gyqB-2fafA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 11 GLY A 253
ILE A 375
LEU A 188
VAL A 186
SER A 189
 None
 1.11A 3gyqB-2fafA:
undetectable		 3gyqB-2fafA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		3 / 3 SER A 258
GLY A 255
SER A 189
 None
1PE  A1262 ( 3.8A)
None
 0.66A 3loqA-2fafA:
undetectable		 3loqA-2fafA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		3 / 3 THR A 403
SER A 404
ARG A  97
 None
 0.76A 3phnA-2fafA:
undetectable		 3phnA-2fafA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 8 ALA A 449
ASP A 448
GLY A 288
VAL A 555
ILE A 559
 None
 1.25A 4ll3A-2fafA:
undetectable		 4ll3A-2fafA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 12 ASP A 330
ASP A 329
PHE A 504
ILE A 331
ALA A 266
 MN  A1701 (-2.3A)
None
None
None
None
 1.27A 4wh5A-2fafA:
undetectable		 4wh5A-2fafA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		4 / 5 ALA A 371
TYR A  90
HIS A 412
PRO A 395
 None
 1.23A 4ze2A-2fafA:
undetectable		 4ze2A-2fafA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 11 MET A 299
LEU A 287
LEU A 556
ILE A 559
LEU A 462
 None
 0.86A 4zowA-2fafA:
undetectable		 4zowA-2fafA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		3 / 3 VAL A 555
ARG A 458
PRO A 598
 None
 0.87A 5koxA-2fafA:
undetectable		 5koxA-2fafA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		3 / 3 THR A  36
PRO A  58
ARG A 157
 None
 0.80A 5nd7B-2fafA:
undetectable		 5nd7B-2fafA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		4 / 8 THR A 181
CYH A  56
CYH A 153
LEU A 212
 None
 1.44A 6cnjD-2fafA:
undetectable
6cnjE-2fafA:
undetectable		 6cnjD-2fafA:
10.07
6cnjE-2fafA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 12 TYR A 615
LEU A 631
PHE A 603
VAL A 460
TRP A 604
 None
 1.09A 6djzB-2fafA:
undetectable		 6djzB-2fafA:
16.97