SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2faq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 757
LEU A 668
SER A 732
 None
 0.72A 1e7aA-2faqA:
undetectable		 1e7aA-2faqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 704
HIS A 651
HIS A 710
LYS A 702
 ATP  A1304 (-2.6A)
ATP  A1304 (-4.1A)
ATP  A1304 (-3.9A)
None
 1.29A 1eqbA-2faqA:
undetectable
1eqbB-2faqA:
undetectable		 1eqbA-2faqA:
22.76
1eqbB-2faqA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 704
HIS A 651
HIS A 710
LYS A 702
 ATP  A1304 (-2.6A)
ATP  A1304 (-4.1A)
ATP  A1304 (-3.9A)
None
 1.28A 1eqbA-2faqA:
undetectable
1eqbB-2faqA:
undetectable		 1eqbA-2faqA:
22.76
1eqbB-2faqA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 704
HIS A 651
HIS A 710
LYS A 702
 ATP  A1304 (-2.6A)
ATP  A1304 (-4.1A)
ATP  A1304 (-3.9A)
None
 1.29A 1eqbC-2faqA:
undetectable
1eqbD-2faqA:
undetectable		 1eqbC-2faqA:
22.76
1eqbD-2faqA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 704
HIS A 651
HIS A 710
LYS A 702
 ATP  A1304 (-2.6A)
ATP  A1304 (-4.1A)
ATP  A1304 (-3.9A)
None
 1.29A 1eqbC-2faqA:
undetectable
1eqbD-2faqA:
undetectable		 1eqbC-2faqA:
22.76
1eqbD-2faqA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 775
LEU A 569
SER A 565
LEU A 557
 None
 0.77A 1j8uA-2faqA:
undetectable		 1j8uA-2faqA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 821
PHE A 700
ARG A 698
 None
 0.88A 2a3aA-2faqA:
undetectable		 2a3aA-2faqA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 665
SER A 656
TYR A 822
 None
 1.01A 2q2hA-2faqA:
undetectable
2q2hB-2faqA:
undetectable		 2q2hA-2faqA:
16.72
2q2hB-2faqA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 SER A 704
HIS A 651
HIS A 710
LYS A 702
 ATP  A1304 (-2.6A)
ATP  A1304 (-4.1A)
ATP  A1304 (-3.9A)
None
 1.37A 2vmyA-2faqA:
undetectable
2vmyB-2faqA:
undetectable		 2vmyA-2faqA:
22.25
2vmyB-2faqA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 704
HIS A 651
HIS A 710
LYS A 702
 ATP  A1304 (-2.6A)
ATP  A1304 (-4.1A)
ATP  A1304 (-3.9A)
None
 1.30A 2vmyA-2faqA:
undetectable
2vmyB-2faqA:
undetectable		 2vmyA-2faqA:
22.25
2vmyB-2faqA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 MET A 833
ALA A 730
ALA A 728
LEU A 715
VAL A 713
 None
 1.31A 2wuzA-2faqA:
undetectable		 2wuzA-2faqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 MET A 833
ALA A 730
ALA A 728
LEU A 715
VAL A 713
 None
 1.32A 2wuzB-2faqA:
undetectable		 2wuzB-2faqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 613
GLY A 615
ARG A 634
LEU A 619
ILE A 633
 None
 1.11A 3adsA-2faqA:
undetectable		 3adsA-2faqA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 698
ASP A 816
GLU A 812
GLU A 791
 None
 1.38A 3dh0A-2faqA:
undetectable		 3dh0A-2faqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 671
ARG A 752
ARG A 776
 MN  A 501 (-2.5A)
None
ATP  A1304 (-3.0A)
 0.93A 3k37A-2faqA:
undetectable		 3k37A-2faqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 710
TYR A 773
VAL A 770
ASP A 583
 ATP  A1304 (-3.9A)
None
None
None
 1.49A 4eohB-2faqA:
undetectable		 4eohB-2faqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 806
SER A 784
LEU A 580
LEU A 810
 None
 1.11A 4n09A-2faqA:
undetectable		 4n09A-2faqA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 641
GLN A 644
ALA A 642
SER A 552
ILE A 551
 None
None
None
SO4  A1302 (-2.6A)
None
 1.09A 4pd9A-2faqA:
undetectable		 4pd9A-2faqA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 776
ASP A 671
GLY A 708
ASP A 669
 ATP  A1304 (-3.0A)
MN  A 501 (-2.5A)
ATP  A1304 (-3.8A)
MN  A 501 (-2.2A)
 0.85A 5hp1A-2faqA:
3.8		 5hp1A-2faqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 778
ASP A 671
GLY A 708
ASP A 669
 ATP  A1304 (-2.6A)
MN  A 501 (-2.5A)
ATP  A1304 (-3.8A)
MN  A 501 (-2.2A)
 0.89A 5hp1A-2faqA:
3.8		 5hp1A-2faqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 776
ASP A 671
GLY A 708
ASP A 669
 ATP  A1304 (-3.0A)
MN  A 501 (-2.5A)
ATP  A1304 (-3.8A)
MN  A 501 (-2.2A)
 1.25A 5hp1C-2faqA:
3.7		 5hp1C-2faqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 778
ASP A 671
GLY A 708
ASP A 669
 ATP  A1304 (-2.6A)
MN  A 501 (-2.5A)
ATP  A1304 (-3.8A)
MN  A 501 (-2.2A)
 1.18A 5hp1C-2faqA:
3.7		 5hp1C-2faqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 591
GLY A 646
GLY A 594
SER A 590
 None
 0.78A 5o96C-2faqA:
undetectable		 5o96C-2faqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		6 / 12 HIS A 573
PHE A 650
GLY A 594
GLY A 646
ILE A 598
PRO A 560
 None
 1.18A 6b3aA-2faqA:
undetectable		 6b3aA-2faqA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 650
GLY A 594
GLY A 646
ILE A 598
PRO A 560
 None
 1.13A 6b3bA-2faqA:
undetectable		 6b3bA-2faqA:
18.36