SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 ALA A  39
GLY A 131
SER A 140
 None
 0.42A 2ivuA-2favA:
undetectable		 2ivuA-2favA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 LEU A  94
VAL A  96
SER A  81
VAL A 152
LEU A 127
 None
 1.32A 2zlcA-2favA:
undetectable		 2zlcA-2favA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 11 PHE A 133
ILE A  42
GLY A  79
ALA A 113
VAL A  37
 None
 0.84A 3rukD-2favA:
undetectable		 3rukD-2favA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 LYS A 136
PRO A 137
LEU A 138
 None
 0.82A 3tpxE-2favA:
undetectable		 3tpxE-2favA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 TYR A 114
PHE A 117
LEU A 161
VAL A 165
VAL A 156
 None
 1.11A 3u9fB-2favA:
undetectable
3u9fC-2favA:
undetectable		 3u9fB-2favA:
22.55
3u9fC-2favA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 TYR A 114
PHE A 117
LEU A 161
VAL A 165
VAL A 156
 None
 1.10A 3u9fH-2favA:
undetectable
3u9fI-2favA:
undetectable		 3u9fH-2favA:
22.55
3u9fI-2favA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 TYR A 114
PHE A 117
LEU A 161
VAL A 165
VAL A 156
 None
 1.15A 3u9fJ-2favA:
undetectable
3u9fK-2favA:
undetectable		 3u9fJ-2favA:
22.55
3u9fK-2favA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 10 TYR A 114
PHE A 117
LEU A 161
VAL A 165
VAL A 156
 None
 1.18A 3u9fK-2favA:
undetectable		 3u9fK-2favA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 10 TYR A 114
PHE A 117
LEU A 161
VAL A 165
VAL A 156
 None
 1.07A 3u9fR-2favA:
undetectable		 3u9fR-2favA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 11 GLY A 104
ALA A 103
ILE A 132
GLY A 134
VAL A  97
 None
 0.99A 4qgiA-2favA:
undetectable		 4qgiA-2favA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 6 LEU A  54
ALA A  57
LEU A 124
ASN A  32
 None
 0.92A 6f88B-2favA:
undetectable		 6f88B-2favA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 8 VAL A   4
ASN A   5
GLN A 120
ILE A 122
 None
 0.96A 6hzpA-2favA:
undetectable		 6hzpA-2favA:
15.61